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Table 2 Common treatment-emergent adverse events (most to least prevalent)

From: A controlled trial of quetiapine XR coadministration treatment of SSRI-resistant panic disorder

Adverse event

Quetiapine XR n = 13 (N, %)

Placebo n = 13 (N, %)

Somnolencea

10 (77 %)

5 (38 %)

Anxiety

4 (31 %)

0 (0 %)

Constipation

3 (23 %)

1 (8 %)

Dry mouth

3 (23 %)

0 (0 %)

Dizziness

2 (15 %)

3 (23 %)

Restlessness

2 (15 %)

4 (31 %)

Derealizationa

2 (15 %)

0 (0 %)

Insomnia

1 (8 %)

3 (23 %)

Increased appetite

1 (8 %)

2 (15 %)

Leg pain

1 (8 %)

1 (8 %)

Weight loss

1 (8 %)

0 (0 %)

Shakiness

1 (8 %)

0 (0 %)

Muscle aches

0 (0 %)

2 (15 %)

Weight gain

0 (0 %)

1 (8 %)

  1. No significant differences between groups were detected at the p < 0.05 level (Fisher’s exact test)
  2. a3 patients in the XR group discontinued due to side-effects (somnolence or derealization). There were no serious AEs (ones requiring ER or inpatient care)