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Table 1 Case reports involving lamotrigine overdose

From: Rhabdomyolysis after lamotrigine overdose: a case report and review of the literature

Case report

Amount of lamotrigine

Disease

Age

Other drugs

Clinical presentation

[16]

4.1 g

Epilepsy

42 year

Status epilepticus, ataxia,

[19]

2.7 g

Bipolar disorder

49 year

Anticonvulsant hypersensitivity syndrome

[5]

1350 mg

Epilepsy

26 year

Ataxia, nystagmus

[15]

800 mg

No disease

2 year

Generalized seizures, ataxia

[13]

43 mg/kg

 

2 year

Generalized seizures

[14]

Unknown

No disease

19 month

Generalized seizures

[17]

32 g

Epilepsy

29 month

Pregabalin

Reduced levels of consciousness, seizures

[18]

9.2 g

Bipolar disorder

23 year

Citalopram, chlorpheniramine

Reduced levels of consciousness, ECG abnormalities

[8]

4.5 g

Epilepsy

32 year

Ethanol, clonazepam

Ataxia, rotary nystagmus

[22]

2 g

Epilepsy

17 year

Gabapentin

Reduced levels of consciousness, dysarthria, motor incoordination

[9]

600 mg

Epilepsy

31 year

Topiramate, carbamazepine

Nystagmus

[11]

39 mg/L

Epilepsy, depression

21 year

Ethanol, thioridazine, carbamazepine, paroxetine

Death

[20]

Unknown

Bipolar disorder

29 year

Ethanol

Coma, seizures, mild rhabdomyolysis

[21]

Unknown

Epilepsy

55 year

Valproic

Stupor

[6]

7.5 g

 

48 year

Status epilepticus, cardiovascular collapse

[7]

     

[12]

4 g

Bipolar disorder

19 year

Seizures, respiratory arrest, complete heart block, death

[23]

4 g

Bipolar disorder, ADHD

17 year

Bupropion

Seizures, cardiovascular collapse