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Table 1 Case reports involving lamotrigine overdose

From: Rhabdomyolysis after lamotrigine overdose: a case report and review of the literature

Case report Amount of lamotrigine Disease Age Other drugs Clinical presentation
[16] 4.1 g Epilepsy 42 year Status epilepticus, ataxia,
[19] 2.7 g Bipolar disorder 49 year Anticonvulsant hypersensitivity syndrome
[5] 1350 mg Epilepsy 26 year Ataxia, nystagmus
[15] 800 mg No disease 2 year Generalized seizures, ataxia
[13] 43 mg/kg   2 year Generalized seizures
[14] Unknown No disease 19 month Generalized seizures
[17] 32 g Epilepsy 29 month Pregabalin Reduced levels of consciousness, seizures
[18] 9.2 g Bipolar disorder 23 year Citalopram, chlorpheniramine Reduced levels of consciousness, ECG abnormalities
[8] 4.5 g Epilepsy 32 year Ethanol, clonazepam Ataxia, rotary nystagmus
[22] 2 g Epilepsy 17 year Gabapentin Reduced levels of consciousness, dysarthria, motor incoordination
[9] 600 mg Epilepsy 31 year Topiramate, carbamazepine Nystagmus
[11] 39 mg/L Epilepsy, depression 21 year Ethanol, thioridazine, carbamazepine, paroxetine Death
[20] Unknown Bipolar disorder 29 year Ethanol Coma, seizures, mild rhabdomyolysis
[21] Unknown Epilepsy 55 year Valproic Stupor
[6] 7.5 g   48 year Status epilepticus, cardiovascular collapse
[7]      
[12] 4 g Bipolar disorder 19 year Seizures, respiratory arrest, complete heart block, death
[23] 4 g Bipolar disorder, ADHD 17 year Bupropion Seizures, cardiovascular collapse