From: Rhabdomyolysis after lamotrigine overdose: a case report and review of the literature
Case report | Amount of lamotrigine | Disease | Age | Other drugs | Clinical presentation |
---|---|---|---|---|---|
[16] | 4.1 g | Epilepsy | 42 year | – | Status epilepticus, ataxia, |
[19] | 2.7 g | Bipolar disorder | 49 year | – | Anticonvulsant hypersensitivity syndrome |
[5] | 1350 mg | Epilepsy | 26 year | – | Ataxia, nystagmus |
[15] | 800 mg | No disease | 2 year | – | Generalized seizures, ataxia |
[13] | 43 mg/kg | 2 year | – | Generalized seizures | |
[14] | Unknown | No disease | 19 month | – | Generalized seizures |
[17] | 32 g | Epilepsy | 29 month | Pregabalin | Reduced levels of consciousness, seizures |
[18] | 9.2 g | Bipolar disorder | 23 year | Citalopram, chlorpheniramine | Reduced levels of consciousness, ECG abnormalities |
[8] | 4.5 g | Epilepsy | 32 year | Ethanol, clonazepam | Ataxia, rotary nystagmus |
[22] | 2 g | Epilepsy | 17 year | Gabapentin | Reduced levels of consciousness, dysarthria, motor incoordination |
[9] | 600 mg | Epilepsy | 31 year | Topiramate, carbamazepine | Nystagmus |
[11] | 39 mg/L | Epilepsy, depression | 21 year | Ethanol, thioridazine, carbamazepine, paroxetine | Death |
[20] | Unknown | Bipolar disorder | 29 year | Ethanol | Coma, seizures, mild rhabdomyolysis |
[21] | Unknown | Epilepsy | 55 year | Valproic | Stupor |
[6] | 7.5 g | 48 year | – | Status epilepticus, cardiovascular collapse | |
[7] | |||||
[12] | 4 g | Bipolar disorder | 19 year | – | Seizures, respiratory arrest, complete heart block, death |
[23] | 4 g | Bipolar disorder, ADHD | 17 year | Bupropion | Seizures, cardiovascular collapse |