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Table 3 Symptom severity at baseline in bipolar I and II subgroups (ITT population)

From: Bipolar II compared with bipolar I disorder: baseline characteristics and treatment response to quetiapine in a pooled analysis of five placebo-controlled clinical trials of acute bipolar depression

Symptom rating scale Bipolar I Bipolar II Total
Depression
MADRS
 n 1809 922 2731
 Mean (SD) 29.4 (6.2) 27.8 (6.7) 28.8 (6.4)
HAM-D
 n 1809 922 2731
 Mean (SD) 24.5 (3.4) 24.1 (3.2) 24.4 (3.4)
Anxiety
HAM-Aa
 n 1591 868 2459
 Mean (SD) 18.3 (6.3) 19.0 (6.2) 18.5 (6.3)
Mania/hypomania
YMRS
 n 1809 922 2731
 Mean (SD) 5.2 (3.1) 4.7 (2.9) 5.1 (3.1)
Global severity of illness
CGI-S
 n 1808 922 2730
 Mean (SD) 4.4 (0.7) 4.3 (0.7) 4.4 (0.7)
  1. Rating scale ranges: CGI-S: total score range 0–7; HAM-A: total score range 0–56; HAM-D: total score range 0–52; MADRS: total score range 0–60; YMRS: total score range 0–60. For all rating scales, a high score represents greater severity
  2. CGI-S clinical global impression-severity, HAM-A Hamilton rating scale for anxiety, HAM-D Hamilton depression rating scale, 17 item, ITT intent-to-treat, MADRS Montgomery–Åsberg depression rating scale, YMRS Young Mania rating scale
  3. aHAM-A was not measured in Suppes et al. [25]