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Table 7 Weight, plasma glucose, and lipid data (safety population)

From: Bipolar II compared with bipolar I disorder: baseline characteristics and treatment response to quetiapine in a pooled analysis of five placebo-controlled clinical trials of acute bipolar depression

Mean (SD) change from randomization Quetiapine Placebo Lithium Paroxetine
BPI
(n = 1217)
BPII
(n = 632)
BPI
(n = 500)
BPII
(n = 242)
BPI
(n = 87)
BPII
(n = 49)
BPI
(n = 76)
BPII
(n = 45)
Mean weight change (kg) 1.1 (4.8) 1.3 (5.5) −0.0 (2.5) 0.1 (2.4) 0.1 (2.1) 0.3 (2.2) −0.4 (3.2) −0.0 (1.9)
Weight change ≥ 7 %, n (%) 85 (7.0) 44 (7.0) 11 (2.2) 5 (2.1) 2 (2.3) 1 (2.0) 2 (2.6) 1 (2.2)
Glucose (mg/dL) 4.6 (21.5) 3.0 (14.4) 4.0 (20.3) 2.4 (14.6) 2.2 (18.9) 2.8 (11.8) 3.3 (13.2) −1.9 (15.3)
Insulin (pm/L) 49.9 (192.7) 27.9 (111.1) 15.6 (142.3) 19.1 (112.6) 6.0 (120.1) −18.3 (101.2) 14.5 (83.9) 15.0 (100.4)
Total cholesterol (mg/dL) −1.8 (31.9) −0.9 (31.6) −3.3 (27.6) −4.9 (31.2) −3.0 (37.9) −9.3 (31.5) −4.7 (37.9) 0.3 (30.9)
LDL-cholesterol (mg/dL) −3.1 (28.2) −2.8 (26.5) −3.2 (24.3) −5.1 (23.5) −3.9 (32.6) −6.8 (28.0) −5.9 (32.8) −3.3 (27.7)
HDL-cholesterol (mg/dL) −0.9 (9.4) −1.0 (9.3) 0.2 (8.8) −1.3 (8.9) −0.9 (13.3) 0.0 (8.9) 0.6 (12.4) 1.1 (10.2)
Triglycerides (mg/dL) 18.6 (112.8) 16.9 (85.1) −1.1 (111.8) 8.7 (112.2) 2.8 (81.1) −0.9 (62. 6) −5.0 (106.8) 26.9 (91.5)