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Table 8 Demographic, clinical and therapeutic characteristics of Depressives patients according to the MTHFR C766T genotypes

From: CT genotype of 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is protector factor of major depressive disorder in the Tunisian population: a case control study

 

MTHFR

p

CC

CT

TT

Age

45.37 ± 13.036

42.16 ± 14.132

45.09 ± 13.287

0.261

BMI

27.127 ± 5.992

26.8113 ± 5.992

27.965 ± 5.201

0.685

Gender

 Man

43 (47.2 %)

37 (40.7 %)

11 (12.1 %)

0.707

 Women

62 (53 %)

43 (36.8 %)

12 (10.2 %)

 

Alcohol

 Yes

12 (28.6 %)

26 (61.9 %)

4 (9.5 %)

0.001

 No

19 (11.6)

52 (31.7 %)

93 (56.7 %)

 

Drugs

 Yes

5 (29.4 %)

12 (70.6 %)

(0 %)0

0.013

 No

100 (52.4 %)

68 (35.6 %)

23 (12 %)

 

Smoker

 Yes

28 (41.2 %)

34 (50 %)

6 (8.8 %)

0.058

 No

77 (55 %)

46 (32.9 %)

17 (12.1 %)

 

Suicide attempts

 Yes

9 (32.1 %)

14 (50 %)

5 (17.9 %)

0.099

 No

96 (53.3 %)

66 (36.7)

18 (10 %)

 

Characteristics

 Psychotic

19 (45.2 %)

16 (38.1 %)

7 (16.7 %)

0.705

 Melancholic

71 (51.1 %)

55 (39.6 %)

13 (9.3 %)

 

 Atypical

15 (55.6 %)

9 (33.3 %)

3 (11.1 %)

 

Severity 2

 Low

12 (36.4 %)

14 (42.4 %)

7 (21.2 %)

0.052

 Medium

75 (55.1 %)

52 (38.2 %)

9 (6.7 %)

 Severe

18 (46.2 %)

14 (35.9 %)

7 (17.9 %)

Anxiety associated

 Yes

60 (54.1)

39 (35.1)

12 (10.8)

0.522

 No

45 (46.4)

41 (42.3)

11 (11.3)

 

Type of anxiety

 Panic

23 (67.7 %)

10 (29.4)

1 (2.9 %)

0.129

 General anxiety

37 (48.1 %)

30 (38.9 %)

10 (13 %)

 

 Obsessive compulsive

4 (100 %)

0

0

 

 Panic and general anxiety

0

1 (100 %)

0

 

Personality disorders

 No

39 (50 %)

32 (41.1 %)

7 (8.9 %)

0.702

 Yes

66 (50.8 %)

48 (36.9 %)

16 (12.3 %)

 

Cluster

 Cluster A

1 (25 %)

2 (50 %)

1 (25 %)

0.818

 Cluster B

18 (48.7 %)

15 (40.5 %)

4 (10.8 %)

 

 Cluster C

10 (55.6 %)

6 (33.3)

2 (11.1 %)

 

Adaptation

 No

27 (54 %)

19 (38 %)

4 (8 %)

0.662

 Almost

44 (45.4 %)

40 (41.2 %)

13 (13.4 %)

 

 Better

34 (55.8 %)

21 (34.4 %)

6 (9.8 %)

 

Treatment

 No

28 (54.9 %)

18 (35.3 %)

5 (9.8 %)

0.806

 TCA

19 (45.2 %)

16 (38.1 %)

7 (16.7 %)

 

 SIRS

48 (51.1 %)

37 (39.3 %)

9 (9.6 %)

 

 Atypical

8 (50 %)

6 (37.5 %)

2 (12.5 %)

 

 TCA + SIRS

2 (33.3 %)

4 (66.7 %)

0

 

Antidepressor

 Amitriptyline

10 (40 %)

11 (44 %)

4 (16 %)

0.557

 Clomipramine

11 (52.4 %)

7 (33.3 %)

3 (14.3 %)

 

 Escitalopram

1 (14.3 %)

4 (57.1 %)

2 (28.6 %)

 

 Fluoxétine

38 (56.7 %)

23 (34.3 %)

6 (9 %)

 

 Paroxétine

9 (56.3 %)

6 (37.5 %)

1 (6.2 %)

 

 Sertraline

2 (40 %)

3 (60 %)

0

 
  1. SIRS selective inhibitors of serotonin reuptake, TCA tricyclic antidepressant, Atypical venlafaxine, milnacipran