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Table 8 Demographic, clinical and therapeutic characteristics of Depressives patients according to the MTHFR C766T genotypes

From: CT genotype of 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is protector factor of major depressive disorder in the Tunisian population: a case control study

  MTHFR p
CC CT TT
Age 45.37 ± 13.036 42.16 ± 14.132 45.09 ± 13.287 0.261
BMI 27.127 ± 5.992 26.8113 ± 5.992 27.965 ± 5.201 0.685
Gender
 Man 43 (47.2 %) 37 (40.7 %) 11 (12.1 %) 0.707
 Women 62 (53 %) 43 (36.8 %) 12 (10.2 %)  
Alcohol
 Yes 12 (28.6 %) 26 (61.9 %) 4 (9.5 %) 0.001
 No 19 (11.6) 52 (31.7 %) 93 (56.7 %)  
Drugs
 Yes 5 (29.4 %) 12 (70.6 %) (0 %)0 0.013
 No 100 (52.4 %) 68 (35.6 %) 23 (12 %)  
Smoker
 Yes 28 (41.2 %) 34 (50 %) 6 (8.8 %) 0.058
 No 77 (55 %) 46 (32.9 %) 17 (12.1 %)  
Suicide attempts
 Yes 9 (32.1 %) 14 (50 %) 5 (17.9 %) 0.099
 No 96 (53.3 %) 66 (36.7) 18 (10 %)  
Characteristics
 Psychotic 19 (45.2 %) 16 (38.1 %) 7 (16.7 %) 0.705
 Melancholic 71 (51.1 %) 55 (39.6 %) 13 (9.3 %)  
 Atypical 15 (55.6 %) 9 (33.3 %) 3 (11.1 %)  
Severity 2
 Low 12 (36.4 %) 14 (42.4 %) 7 (21.2 %) 0.052
 Medium 75 (55.1 %) 52 (38.2 %) 9 (6.7 %)
 Severe 18 (46.2 %) 14 (35.9 %) 7 (17.9 %)
Anxiety associated
 Yes 60 (54.1) 39 (35.1) 12 (10.8) 0.522
 No 45 (46.4) 41 (42.3) 11 (11.3)  
Type of anxiety
 Panic 23 (67.7 %) 10 (29.4) 1 (2.9 %) 0.129
 General anxiety 37 (48.1 %) 30 (38.9 %) 10 (13 %)  
 Obsessive compulsive 4 (100 %) 0 0  
 Panic and general anxiety 0 1 (100 %) 0  
Personality disorders
 No 39 (50 %) 32 (41.1 %) 7 (8.9 %) 0.702
 Yes 66 (50.8 %) 48 (36.9 %) 16 (12.3 %)  
Cluster
 Cluster A 1 (25 %) 2 (50 %) 1 (25 %) 0.818
 Cluster B 18 (48.7 %) 15 (40.5 %) 4 (10.8 %)  
 Cluster C 10 (55.6 %) 6 (33.3) 2 (11.1 %)  
Adaptation
 No 27 (54 %) 19 (38 %) 4 (8 %) 0.662
 Almost 44 (45.4 %) 40 (41.2 %) 13 (13.4 %)  
 Better 34 (55.8 %) 21 (34.4 %) 6 (9.8 %)  
Treatment
 No 28 (54.9 %) 18 (35.3 %) 5 (9.8 %) 0.806
 TCA 19 (45.2 %) 16 (38.1 %) 7 (16.7 %)  
 SIRS 48 (51.1 %) 37 (39.3 %) 9 (9.6 %)  
 Atypical 8 (50 %) 6 (37.5 %) 2 (12.5 %)  
 TCA + SIRS 2 (33.3 %) 4 (66.7 %) 0  
Antidepressor
 Amitriptyline 10 (40 %) 11 (44 %) 4 (16 %) 0.557
 Clomipramine 11 (52.4 %) 7 (33.3 %) 3 (14.3 %)  
 Escitalopram 1 (14.3 %) 4 (57.1 %) 2 (28.6 %)  
 Fluoxétine 38 (56.7 %) 23 (34.3 %) 6 (9 %)  
 Paroxétine 9 (56.3 %) 6 (37.5 %) 1 (6.2 %)  
 Sertraline 2 (40 %) 3 (60 %) 0  
  1. SIRS selective inhibitors of serotonin reuptake, TCA tricyclic antidepressant, Atypical venlafaxine, milnacipran