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Table 1 Characteristics of the patients in the daily treatment group and twice weekly treatment group

From: Twice-weekly aripiprazole for treating children and adolescents with tic disorder, a randomized controlled clinical trial

  Daily treatment group Twice weekly treatment group Significance
Mean (SD) years of age 10.5 (3.1) 10.8 (2.0) t = .3, df = 34, P = 0.72
Gender
Boys 16 (80 %) 14 (87.5 %) P = 0.67
Girls 4 (20 %) 2 (12.5 %)
Comorbid psychiatric disorder
ADHD 6 (37.5 %) 5 (41.7 %) X2 = 0.05, df = 1, P = 0.8
Oppositional defiant disorder 7 (43.8 %) 7 (58.3 %) X2 = 0.5, df = 1, P = 0.4
Separation anxiety disorder 0 2 (16.7 %)
Obsessive compulsive disorder 1 (6.2 %) 0
Con-current medications (n)
Carbamazepine 1
Ritalin (10 mg/day) 1
Imipramine (10 mg/day) + haloperidole (0.5 mg/day) 1
Mean dosage of aripiprazole
First 2 weeks 3.5 3.8
Second 2 weeks 3.8 4.6
Second month 4.0 4.5
Motor and vocal tics score
Baseline 33.6 (18.2) 31.3 (7.6) t = .4, df = 34, P = 0.6
Week 2 15.1 (10.8) 12.8 (9.1) t = 0.6, df = 32, P = 0.52
Week 4 11.0 (9.7) 12.8 (10.9) t = 0.5, df = 31, P = 0.6
Week 8 6.6 (5.9) 9.7 (11.2) t = 1.03, df = 32, P = 0.3
Mean (SD) decline of total Yale motor and vocal tic severity scale score during trial 22.8 (18.5) 22.0 (11.6) t = 1.07, df = 32, P = 0.2
Response rate with more than 35 % decline in total Yale motor and vocal tic severity scale score 19 (100.0 %) 11 (73.3 %) P < 0.02
Response rate with more than 50 % decline in total Yale motor and vocal tic severity scale score 17 (89.5 %) 11 (73.3 %) P = 0.2
Total Yale global tic severity scale score (motor tics + vocal tics + impairments)
Baseline 89.6 (39.2) 93.8 (29.3) t = 0.3, df = 34, P = 0.72
Week 2 39.5 (33.33) 37.8 (31.3) t = 0.1, df = 32, P = 0.8
Week 4 27.1 (31.9) 39.2 (36.7) t = 1.0, df = 31, P = 0.31
Week 8 15.3 (17.2) 29.7 (37.1) t = 1.4, df = 32, P = 0.14
Mean (SD) decline of total Yale global tic severity scale score during trial (motor tics + vocal tics + impairments) 76 (37.9) 64.6 (44.2) t = 0.8, df = 32, P = 0.4
Response rate with more than 35 % decline in total Yale global tic severity scale score (motor tics + vocal tics + impairments) 19 (100.0 %) 11 (73.3 %) P < 0.02
Response rate with more than 50 % decline in total Yale global tic severity scale score (motor tics + vocal tics + impairments) 17 (89.5 %) 11 (73.3 %) P = 0.3