Fig. 1From: Multi-regression analysis revealed a relationship between l-serine and methionine, a component of one-carbon metabolism, in the normal control but not in the schizophreniaThe carbon atom of one-carbon metabolism is exchanged between l-serine and methionine. The folate cycle obtains the methylene group (one carbon atom) from l-serine via the catalysis of serine hydroxymethyltransferase (SHMT) and subsequently donates the carbon to methionine synthesis. l-serine becomes glycine by offering the methylene group to methionine synthesis. Methionine is synthesized from homocysteine (Hcy) using a folate cycle-derived carbon atom. MTHFR methylenetetrahydrofolate reductase; MTR 5-methyltetrahydrofolate-homocysteine methyltransferaseBack to article page