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Table 4 Relationship between PANSS score and other factors in patients with schizophrenia: multiple regression analysis

From: Multi-regression analysis revealed a relationship between l-serine and methionine, a component of one-carbon metabolism, in the normal control but not in the schizophrenia

  Forced entry model Backward elimination model
β ± SD p value VIF β ± SD p value VIF
PANSS score
 Sex −0.13 ± 0.22 0.57 2.42    
 Age −0.62 ± 0.32 0.06 5.04 −0.54 ± 0.15 <0.001 1.16
 Smoking status −0.15 ± 0.20 0.44 1.91    
 Duration of illness 0.16 ± 0.25 0.53 3.22    
 CP equivalent dose 0.11 ± 0.18 0.52 1.38    
 Vitamin B12 0.05 ± 0.15 0.76 1.31    
 Folate 0.30 ± 0.19 0.12 1.73 0.35 ± 0.16 0.04 1.41
 Homocysteine 0.38 ± 0.21 0.09 2.31 0.27 ± 0.16 0.10 1.43
 l-serine 0.00 ± 0.00 1.00 3.26    
 d-serine 0.43 ± 0.25 0.10 3.08 0.38 ± 0.14 0.01 1.07
 Glycine −0.13 ± 0.20 0.53 2.13    
 Methionine 0.34 ± 0.16 0.05 1.35 0.29 ± 0.15 0.07 1.29
 Genotype131 −0.29 ± 0.20 0.16 1.96 −0.25 ± 0.15 0.10 1.18
 Genotype133 −0.14 ± 0.23 0.55 2.61    
Positive PANSS score
 Sex −0.03 ± 0.21 0.89 2.42 −0.71 ± 0.19 <0.001 2.21
 Age −0.68 ± 0.30 0.04 5.04    
 Smoking status −0.04 ± 0.18 0.82 1.91    
 Duration of illness 0.25 ± 0.24 0.32 3.22 0.31 ± 0.19 0.11 2.07
 CP equivalent dose 0.12 ± 0.12 0.45 1.38    
 Vitamin B12 0.14 ± 0.16 0.38 1.31    
 Folate 0.32 ± 0.18 0.08 1.73 0.25 ± 0.14 0.08 1.12
 Homocysteine 0.31 ± 0.20 0.15 2.31    
 l-serine 0.07 ± 0.24 0.77 3.26    
 d-serine 0.22 ± 0.24 0.36 3.08    
 Glycine 0.31 ± 0.20 0.13 2.13 0.47 ± 0.13 <0.001 1.06
 Methionine 0.26 ± 0.16 0.11 1.35 0.19 ± 0.15 0.20 1.25
 Genotype131 −0.32 ± 0.19 0.11 1.96 −0.23 ± 0.14 0.11 1.16
 Genotype133 −0.06 ± 0.22 0.78 2.61    
Negative PANSS score
 Sex −0.05 ± 0.23 0.82 2.42    
 Age −0.42 ± 0.34 0.23 5.04 −0.25 ± 0.15 0.11 1.07
 Smoking status −0.18 ± 0.21 0.38 1.91 −0.27 ± 0.16 0.11 1.27
 Duration of illness 0.15 ± 0.27 0.58 3.22    
 CP equivalent dose 0.12 ± 0.24 0.50 1.38    
 Vitamin B12 0.05 ± 0.18 0.79 1.31    
 Folate 0.14 ± 0.20 0.49 1.73    
 Homocysteine 0.37 ± 0.23 0.12 2.31 0.24 ± 0.18 0.19 1.48
 l-serine 0.14 ± 0.27 0.61 3.26    
 d-serine 0.30 ± 0.26 0.27 3.08 0.47 ± 0.19 0.02 1.73
 Glycine −0.53 ± 0.22 0.02 2.13 −0.61 ± 0.20 0.004 1.76
 Methionine 0.28 ± 0.17 0.12 1.35    
 Genotype131 −0.37 ± 0.21 0.09 1.96 −0.16 ± 0.15 0.30 1.10
 Genotype133 −0.31 ± 0.24 0.22 2.61    
  1. β standardised partial regression coefficient, VIF variance inflation factor