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Table 1 Patient characteristics at baseline

From: Effect of mirtazapine versus selective serotonin reuptake inhibitors on benzodiazepine use in patients with major depressive disorder: a pragmatic, multicenter, open-label, randomized, active-controlled, 24-week trial

Variable Mirtazapine
(n = 27)
SSRIs
(n = 50)
P Sertraline
(n = 32)
Paroxetine
(n = 18)
P
Male patients, n (%) 18 (66.7) 32 (64.0) nsc 20 (62.5) 12 (66.7) nsc
Age, mean (SD), years 38.9 (10.5) 40.4 (13.8) nsa 39.7 (13.3) 41.7 (14.9) nsb
Age at onset, mean (SD), years 38.1 (10.5) 39.3 (13.1) nsa 39.0 (12.5) 39.8 (14.5) nsb
Duration of illness, median [quartiles], week 30.0 [8.0–104.0] 20.0 [12.0–71.0] nsa 20.0 [8.0–58.5] 19.0 [12.0–117.0] nsb
Duration of current episode, median [quartiles], week 12.0 [7.0–40.0] 12.0 [8.0–34.0] nsa 14.0 [7.3–44.0] 12.0 [12.0–21.0] nsb
Depressive episodes    nsc    nsc
 Single, n (%) 22 (81.5) 42 (84.0)   28 (87.5) 14 (77.8)  
 Recurrent, n (%)d 5 (18.5) 8 (16.0)   4 (12.5) 4 (22.2)  
Past history of using any psychiatric services, n (%) 4 (14.8) 15 (30.0) nsc 11 (34.4) 4 (22.2) nsc
Past history of any psychotropic medication, n (%) 11 (40.7) 18 (36.0) nsc 14 (43.8) 4 (22.2) nsc
Treatments of the current episode, n (%) 4 (14.8) 5 (10.0) nsc 5 (15.6) 0 (0.0) nsc
Antidepressant treatment of the current episode, n (%) 3 (11.1) 3 (6.0) nsc 3 (9.4) 0 (0.0) nsc
Benzodiazepine treatment of the current episode, n (%) 1 (3.7) 1 (2.0) nsc 1 (3.1) 0 (0.0) nsc
HDRS, mean (SD) 23.0 (5.2) 23.1 (6.1) nsa 23.2 (6.2) 22.9 (6.0) nsb
SDS, mean (SD) 55.9 (5.4) 57.9 (7.8) nsa 57.9 (7.4) 57.9 (7.1) nsb
AIS, mean (SD) 11.2 (3.7) 12.9 (4.4) nsa 12.8 (4.3) 13.1 (4.7) nsb
CGI-S, median [quartiles] 4.0 [4.0–5.0] 4.0 [4.0–5.0] nsa 4.5 [4.0–5.0] 4.0 [4.0–5.0] nsb
  1. SSRI selective serotonin reuptake inhibitor, SD standard variation, HDRS 17-item Hamilton depression rating scale, SDS Zung self-rating depression scale, AIS Athens insomnia scale, CGI-S clinical global impressions-severity
  2. aUnpaired t test or Mann–Whitney U test
  3. bOne-way analysis of variance (ANOVA) or Kruskal–Wallis test
  4. cChi-square test or Fisher exact test
  5. dMaximum number of recurrent episodes is two