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Table 6 Baseline serum brain-derived neurotrophic factor (BDNF) levels of responders and non-responders at week 6

From: Effect of mirtazapine versus selective serotonin reuptake inhibitors on benzodiazepine use in patients with major depressive disorder: a pragmatic, multicenter, open-label, randomized, active-controlled, 24-week trial

  Responders, n = 24 Non-responders, n = 29 Statistics P
Levels at baseline
 Mature BDNF (ng/mL), mean (SD) 12.8 (3.8) 13.4 (3.4) t = −0.67, df = 51 0.51
 ProBDNF (pg/mL), median [quartiles] 607.5 [84.4, 5158.3] 135.0 [45.6, 2803.5] Z = −1.3 0.18
 Ratio of mature BDNF/proBDNFa 25.7 [2.3, 146.8] 105.7 [4.7, 309.2] Z = −1.3 0.21
  1. Responders and non-responders were assessed at week 6
  2. BDNF brain-derived neurotrophic factor, SD standard deviation
  3. aRatio is serum level of mature BDNF (pg/mL) divided by that of proBDNF (pg/mL) in each individual. Serum mature BDNF levels were analyzed using Student t test. Serum proBDNF and ratio of mature BDNF/proBDNF were analyzed using Mann–Whitney U test