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Table 3 VBM analysis including association of variance between 5-HTTLPR polymorphisms and GM volumes in OCD patients and HCs

From: A pilot study exploring the association of morphological changes with 5-HTTLPR polymorphism in OCD patients

Regions Brodmann area Cluster size Z Talairach coordinates
x, y, z (mm2)
Main effects     
 Diagnosis effects (P < 0.05, FWE, 〈k〉 = 77.666)     
 R hippocampus (OCD patients < HCs)   763 5.08 33, −16, −18
 L precentral gyrus (OCD patients > HCs) 4 797 4.88 −28, −27, 64
Genotype effects     
 No suprathreshold clusters     
 Genotype-diagnosis interaction effects (P < 0.001, uncorrected, 〈k〉 = 63.146)     
R frontal pole 10 112 4.35 26, 50, −6
  1. R right, L left, FWE family-wise error, 〈k〉 expected voxels per clusters