Table 3 MMSE severity by ACE I/D genotypes and alleles in Alzheimer’s patients
ACE I/D genotype and alleles n (%) N = 60 | MMSE ranges n% (C, R, T) | Severe vs. moderate Severe vs. mild | |||
|---|---|---|---|---|---|
0–9 (severe) N = 26 | 10–18 (moderate) N = 22 | 19–23 (mild) N = 12 | OR [CI 95%] | p values | |
II 5 (8) | 0 (0, 0, 0) | 2 (9, 40, 3) | 3 (25, 60, 5) | – 96 [3.2–2800] (*) | .13 .002 |
ID 24 (40) | 6 (23, 25, 10) | 10 (45, 42, 17) | 8 (67, 33, 13) | 3.3 [.94–12] 27 [2.8–260] | .07 < 10 −3 |
II + ID 29 (48) | 6 (23, 21, 10) | 12 (55, 41, 20) | 11 (92, 38, 18) | 4 [1.2–14] 37 [3.9–340 | .04 < 10 −3 |
DD 31 (52) | 20 (77, 65, 33) | 10 (45, 32, 17) | 1 (8, 3, 2) | – – | – – |
I 34 (28) | 6 (12, 18, 5) | 14 (32, 41, 12) | 14 (58, 41, 12) | 3.6 [1.2–10] 11 [3.3–35] | .02 < 10 −3 |
D 86 (72) | 46 (88, 53, 38) | 30 (68, 35, 25) | 10 (42, 12, 8) | – – | |