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Table 3 MMSE severity by ACE I/D genotypes and alleles in Alzheimer’s patients

From: Association between an angiotensin-converting enzyme gene polymorphism and Alzheimer’s disease in a Tunisian population

ACE I/D genotype and alleles n (%)
N = 60
MMSE ranges n% (C, R, T) Severe vs. moderate
Severe vs. mild
0–9 (severe) N = 26 10–18 (moderate) N = 22 19–23 (mild) N = 12 OR [CI 95%] p values
II 5 (8) 0
(0, 0, 0)
2
(9, 40, 3)
3
(25, 60, 5)

96 [3.2–2800] (*)
.13
.002
ID 24 (40) 6
(23, 25, 10)
10
(45, 42, 17)
8
(67, 33, 13)
3.3 [.94–12]
27 [2.8–260]
.07
< 10 −3
II + ID 29 (48) 6
(23, 21, 10)
12
(55, 41, 20)
11
(92, 38, 18)
4 [1.2–14]
37 [3.9–340
.04
< 10 −3
DD 31 (52) 20
(77, 65, 33)
10
(45, 32, 17)
1
(8, 3, 2)


I 34 (28) 6
(12, 18, 5)
14
(32, 41, 12)
14
(58, 41, 12)
3.6 [1.2–10]
11 [3.3–35]
.02
< 10 −3
D 86 (72) 46
(88, 53, 38)
30
(68, 35, 25)
10
(42, 12, 8)

  1. DD versus II, ID, and I* genotypes; Statistics calculated using Fisher’s exact test; (*) Haldane’s correction used; CI confidence interval, % (C, R, T) column %, row %, % of total (all % rounded to nearest whole percentage point), OR odds ratio, p value probability value
  2. Significant p values are in italics