Table 3 MMSE severity by ACE I/D genotypes and alleles in Alzheimer’s patients
|
ACE I/D genotype and alleles n (%) N = 60 | MMSE ranges n% (C, R, T) |
Severe vs. moderate Severe vs. mild | |||
|---|---|---|---|---|---|
| 0–9 (severe) N = 26 | 10–18 (moderate) N = 22 | 19–23 (mild) N = 12 | OR [CI 95%] | p values | |
| II 5 (8) |
0 (0, 0, 0) |
2 (9, 40, 3) |
3 (25, 60, 5) |
– 96 [3.2–2800] (*) |
.13 .002 |
| ID 24 (40) |
6 (23, 25, 10) |
10 (45, 42, 17) |
8 (67, 33, 13) |
3.3 [.94–12] 27 [2.8–260] |
.07 < 10 −3 |
| II + ID 29 (48) |
6 (23, 21, 10) |
12 (55, 41, 20) |
11 (92, 38, 18) |
4 [1.2–14] 37 [3.9–340 |
.04 < 10 −3 |
| DD 31 (52) |
20 (77, 65, 33) |
10 (45, 32, 17) |
1 (8, 3, 2) |
– – |
– – |
| I 34 (28) |
6 (12, 18, 5) |
14 (32, 41, 12) |
14 (58, 41, 12) |
3.6 [1.2–10] 11 [3.3–35] |
.02
< 10 −3 |
| D 86 (72) |
46 (88, 53, 38) |
30 (68, 35, 25) |
10 (42, 12, 8) |
– – | |