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Table 5 Comparison of adverse events between the five kinds of antipsychotics after 6–8 weeks of treatment

From: The efficacy, acceptability, and safety of five atypical antipsychotics in patients with first-episode drug-naïve schizophrenia: a randomized comparative trial

Groups N EPS Abnormal ECG Abnormal liver function Constipation Leukopenia
Aripiprazole 15 6 4 5 1 0
Risperidone 20 6 4 6 2 0
Quetiapine 23 3 8 7 3 4
Olanzapine 21 1 8 5 1 2
Ziprasidone 5 3 3 1 0 0
χ 2   12.23 3.75 0.64 1.60 6.899
P value   < 0.05 > 0.05 > 0.05 > 0.05 > 0.05
  1. Abnormal liver function: this mainly included elevated serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST). ECG: electrocardiogram. Including S-T and T wave change, and prolongation of corrected Q-T interval
  2. N: number of patients; EPS: extrapyramidal symptoms, including akathisia, acute dystonia, and parkinsonian syndromes