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Table 5 Comparison of adverse events between the five kinds of antipsychotics after 6–8 weeks of treatment

From: The efficacy, acceptability, and safety of five atypical antipsychotics in patients with first-episode drug-naïve schizophrenia: a randomized comparative trial

Groups

N

EPS

Abnormal ECG

Abnormal liver function

Constipation

Leukopenia

Aripiprazole

15

6

4

5

1

0

Risperidone

20

6

4

6

2

0

Quetiapine

23

3

8

7

3

4

Olanzapine

21

1

8

5

1

2

Ziprasidone

5

3

3

1

0

0

χ 2

 

12.23

3.75

0.64

1.60

6.899

P value

 

< 0.05

> 0.05

> 0.05

> 0.05

> 0.05

  1. Abnormal liver function: this mainly included elevated serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST). ECG: electrocardiogram. Including S-T and T wave change, and prolongation of corrected Q-T interval
  2. N: number of patients; EPS: extrapyramidal symptoms, including akathisia, acute dystonia, and parkinsonian syndromes