Table 1 Summary of the meta-analysis of the DRD2 rs1076560 in association with SUD in different populations
Population | Substance | Phenotype | Number | Allele’s frequency (%) | p | OR (95% CI) | References | |
|---|---|---|---|---|---|---|---|---|
C | A | |||||||
Caucasians | Alcohol | Case | 171 | 79.00 | 21.00 | 0.14 | 1.34 (0.90–1.98) | [30] |
Control | 160 | 83.00 | 17.00 | |||||
African Americans | Opioid | Case | 278 | 88.00 | 12.00 | 0.03 | 1.43 (1.04–1.97) | [9] |
Control | 750 | 91.00 | 9.00 | |||||
European Americans | Case | 999 | 83.00 | 17.00 | 0.02 | 1.27 (1.04–1.54) |  | |
Control | 656 | 86.00 | 14.00 | |||||
African Americans | Cocaine | Case | 45 | 94.00 | 6.00 | 0.53 | 0.66 (0.18–2.40) | [27] |
Control | 31 | 92.00 | 8.00 | |||||
Caucasians | Case | 74 | 76.00 | 24.00 | 0.003 | 2.74 (1.38–5.45) | ||
Control | 63 | 90.00 | 10.00 | |||||
Japanese | Alcohol | Case | 297 | 59.90 | 40.10 | 0.03 | 1.30 (1.02–1.66) | [29] |
Control | 425 | 66.00 | 34.00 | |||||
Jordanian Arabs | Poly-substance | Case | 220 | 84.30 | 15.70 | 0.03 | 1.53 (0.90–2.68) | [30] |
Control | 240 | 89.20 | 10.80 | |||||
UAE Cohort | Mixeda | Case | 250 | 88.20 | 11.80 | 0.52** | 0.88 (0.61–1.28) | This study |
Control | 262 | 86.80 | 13.20 | |||||