Analysis of the SNP rs3747333 and rs3747334 in NLGN4X gene in autism spectrum disorder: a meta-analysis

Table 1 Characteristics of all studies included in the meta-analysis NLGN4X SNP rs3747333 and rs3747334

Author, year	Ethnicity	Study design	Presence in patients/sex ratio		Presence in controls/sex ratio		Genotyping type	Diagnostic criteria	Nucleotide change
Mikhailov (2014)	Thai	Screening	9/143	5.8 M:1F	vs.dpSNP	Unknown	DHPLC^a	DSM-IV^d	c.1777 C>T c.17779C>G
Volaki (2013)	Greek	Screening	11/40	9 M:1F	vs.dpSNP	Unknown	PCR-DS^b	DSM-IV	c.1777 C>T c.17779C>G
Wermter (2008)	German	Screening	7/107	20.4 M:1F	vs.dpSNP	Unknown	PCR–RFLP^c	ICD-10^e	c.1777 C>T c.17779C>G
Blasi (2006)	Italy	Screening	4/31	3.5 M:1F	vs.dpSNP	Unknown	PCR-RFLP^c	DSM-IV	c.1777 C>T c.17779C>G
Gauthier (2005)	Quebec	Case–control	61/96	6.4 M:1F	56/96	8.6 M:1F	NA	DSM-IV, ADI-R^f and ADOS-G^g	c.1777 C>T c.17779C>G
Xiaojuan (2014)	Chinese	Case–control	21/318	5.6 M:1F	4/453	3.0 M:1F	PCR-DS	DSM-IV and CARS^h	c.1777 C>T c.17779C>G

^aDenaturing high-performance liquid chromatography (DHPLC)
^bPolymerase chain reaction-direct sequencing (PCR-DS)
^cPolymerase chain reaction-based restriction fragment length polymorphisms (PCR-RFLP)
^dDiagnostic and Statistical Manual of Mental Disorders, 4th ed. (DSM-IV)
^eTenth Revision of the International Classification of Diseases (ICD–10)
^fAutism specific parent interview (ADI-R)
^gAutism diagnostic observation scale (ADOS-G)
^hChildhood autism rating scale (CARS)

ISSN: 1744-859X