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Table 1 The results of enrichment analysis for genes involved in the pathogenesis of both OCD and BD

From: How obsessive–compulsive and bipolar disorders meet each other? An integrative gene-based enrichment approach

  Gene full official name HGNC symbol Betweenness centrality
1 Calcium voltage-gated channel subunit alpha1 C CACNA1C 0.338153
2 Glutamate ionotropic receptor AMPA-type subunit 1  GRIA1 0.1574122
3 Dopamine receptor D2 DRD2 0.1136524
4 Nitric oxide synthase 1 NOS1 0.0903783
5 Solute carrier family 18 member A1 SLC18A1 0.0661232
6 5-Hydroxytryptamine receptor 2A HTR2A 0.0660831
7 Dopamine receptor D1 DRD1 0.0500920
8 Glutamate ionotropic receptor kainate-type subunit 2 GRIK2 0.0481045
9 Dopamine receptor D5 DRD5 0.0458659
10 5-Hydroxytryptamine receptor 1A, serotonin receptor HTR1A 0.0443705
11 Glutamate ionotropic receptor NMDA-type subunit 2B GRIN2B 0.036738
12 Solute carrier family 6 member 4 SLC6A4 0.020317
13 Glutamate ionotropic receptor kainate-type subunit 3 GRIK3 0.038491
14 Dopamine receptor D3 DRD3 0.017168
15 Cannabinoid receptor 1 CNR1 0.007217
16 Adrenoceptor alpha 1A ADRA1A 0.006255
17 Brain-derived neurotrophic factor BDNF 0.005617
18 Tryptophan hydroxylase 2 TPH2 0.0045508
19 Dopamine receptor D4 DRD4 0.004232
20 Glutamate decarboxylase 1 GAD1 0.003155
21 Gamma-aminobutyric acid type A receptor alpha1 subunit  GABRA1 0.001786
22 Neurotrophic receptor tyrosine kinase 2 NTRK2 0.001023
23 Angiotensin I converting enzyme ACE 0
24 Ataxin 1 ATXN1 0
25 Cholinergic receptor nicotinic alpha 7 subunit CHRNA7 0
26 Corticotropin-releasing hormone receptor 2 CRHR2 0
27 Dopamine beta-hydroxylase DBH 0
28 Ephrin A5 EFNA5 0
29 Glutamic acid decarboxylase 2 GAD2 0
30 Glutamate ionotropic receptor NMDA-type subunit 2A GRIN2A 0
31 5-Hydroxytryptamine receptor 2C HTR2C 0
32 5-Hydroxytryptamine receptor 3A HTR3A 0
33 Olfactomedin 1 OLFM1 0
34 Tumor necrosis factor TNF 0