| |
F2
|
F3
|
F2 vs F3
|
|---|
|
n
|
Mean or ratio
|
SD
|
n
|
Mean or ratio
|
SD
|
T-test or Fisher’s exact test p=
|
Age-adjusted
|
|---|
|
p
|
Mean differences (95% CI)
|
Odds ratios (95% CI)
|
|---|
|
Lipid metabolism
|
|
LDL-C (mg/dl)
|
139
|
113.6
|
38.2
|
44
|
113.5
|
33.9
|
N.S.
|
N.A.
| | |
|
Male
|
59
|
107.3
|
96.4
|
19
|
106.9
|
95.7
|
N.S.
|
N.A.
| | |
|
Female
|
80
|
118.3
|
34.7
|
25
|
118.6
|
39.9
|
N.S.
|
N.A.
| | |
|
HDL-C (mg/dl)
|
139
|
53.9
|
17.8
|
44
|
55.6
|
17.4
|
N.S.
|
N.A.
| | |
|
Male
|
59
|
48.7
|
13.7
|
19
|
49
|
15.4
|
N.S.
|
N.A.
| | |
|
Female
|
80
|
57.7
|
19.6
|
25
|
60.5
|
17.5
|
N.S.
|
N.A.
| | |
|
Triglyceride (mg/dl)
|
143
|
115.5
|
83.0
|
44
|
112
|
63.6
|
N.S.
|
N.A.
| | |
|
Male
|
62
|
126.2
|
94.3
|
19
|
111
|
76.9
|
N.S.
|
N.A.
| | |
|
Female
|
81
|
107.4
|
72.8
|
25
|
113.6
|
52.9
|
N.S.
|
N.A.
| | |
|
Non-HDL-C (mg/dl)
|
139
|
137
|
43.1
|
44
|
135.9
|
38.0
|
N.S.
|
N.A.
| | |
|
Male
|
59
|
133.7
|
48.3
|
19
|
128.9
|
28.2
|
N.S.
|
N.A.
| | |
|
Female
|
80
|
139.5
|
39.0
|
25
|
141.3
|
43.8
|
N.S.
|
N.A.
| | |
|
Glucose metabolism
|
|
Fasting blood glucose (mg/dl)
|
144
|
117.7
|
43.4
|
45
|
131.5
|
76.2
|
N.S.
|
N.S.
|
− 7.2 (− 26.6 to 12.3)
| |
|
Male
|
62
|
117.7
|
47.7
|
20
|
126.8
|
91.0
|
N.S.
|
N.A.
| | |
|
Female
|
82
|
117.7
|
40.2
|
25
|
135.2
|
63.7
|
N.S.
|
N.S.
|
− 11.1 (− 33.5 to 11.4)
| |
|
HbA1c (%)
|
144
|
5.82
|
0.81
|
45
|
6.02
|
1.18
|
N.S.
|
N.S.
|
− 0.01 (− 0.34 to 0.32)
| |
|
Male
|
62
|
5.91
|
1.01
|
20
|
5.97
|
1.62
|
N.S.
|
N.A.
| | |
|
Female
|
82
|
5.75
|
0.60
|
25
|
6.06
|
0.69
|
0.029
|
N.S.
|
− 0.12 (− 0.40 to 0.16)
| |
|
Renal function
|
|
Serum creatinine (mg/dl)
|
144
|
0.696
|
0.234
|
45
|
0.778
|
0.250
|
0.045
|
N.A.
| | |
|
Male
|
62
|
0.788
|
0.218
|
20
|
0.877
|
0.307
|
N.S.
|
N.A.
| | |
|
Female
|
82
|
0.626
|
0.223
|
25
|
0.698
|
0.160
|
N.S.
|
N.A.
| | |
|
eGFR (ml/min)
|
144
|
87.1
|
22.8
|
45
|
72.4
|
21.4
|
0.0002
|
0.0139*
|
10.3 (2.1 to 18.5)
| |
|
Male
|
62
|
90.6
|
22.9
|
20
|
77.1
|
24.9
|
0.027
|
N.S.
|
9.9 (− 4.0 to 23.8)
| |
|
Female
|
82
|
84.4
|
22.5
|
25
|
68.7
|
17.8
|
0.002
|
0.0225*
|
12 (1.7 to 22.3)
| |
|
Ratio of eGFR < 60 ml/min
|
144
|
0.076
| |
45
|
0.244
| |
0.006
|
N.S.
| |
0.45 (0.16–1.2)
|
|
Male
|
62
|
0.048
| |
20
|
0.15
| |
N.S.
|
N.S.
| |
0.48 (0.07–3.7)
|
|
Female
|
82
|
0.098
| |
25
|
0.32
| |
0.011
|
N.S.
| |
0.36 (0.11–1.2)
|
|
Ratio of albuminuria (30 mg/g creatinine <) (40 years <)
|
93
|
0.043
| |
33
|
0.152
| |
N.S.
|
N.S.
| |
0.34 (0.08–1.41)
|
|
Male
|
37
|
0.027
| |
14
|
0.071
| |
N.S.
|
N.S.
| |
0.53 (0.03–10.1)
|
|
Female
|
56
|
0.054
| |
19
|
0.211
| |
N.S.
|
N.S.
| |
0.27 (0.05–1.44)
|
- First, we used t-test in quantitative variables and Fisher’s exact test in qualitative variables between F2 and F3 groups without any adjustments. Next, Age-adjusted mean differences were estimated using ANCOVA and Odds ratios were calculated using logistic regression analysis. CI is an abbreviation of confidence interval. N.A. means not applicable. N.S. means not significant (p ≥ 0.05). * is significantly different (p < 0.05) between F2 group and F3 group by age-adjusted analysis
