From: Efficacy of nicotine administration on obsessions and compulsions in OCD: a systematic review
First author/s (year of publication) | Country | Study design (number of participants) | Method and method of nicotine administration | Assessment methods | Key findings | |
---|---|---|---|---|---|---|
With treatment as outcome | ||||||
Carlsson and Carlsson [30] | Sweden | Case report (N = 1) | Monotherapy; 2 mg chewing gums × 8 weeks, then > 1 year with doses escalated by patient | Y-BOCS | 1 DSM-IV OCD outpatient. ↓ Y-BOCS total score (45.45%) and obsession and compulsion subscale scores | |
SalÃn-Pascual and Basañez-Villa [82] | Mexico | Randomized controlled (N = 11) | Monotherapy; 17.5 mg transdermal patches × 5 consecutive days | Y-BOCS, BAI, BDI | 6 DSM-IV OCD female and 5 DSM-IV OCD male outpatients. ↓ Y-BOCS total score (36.20%) and compulsion subscale scores. ↓ BAI scores. No changes in BDI scores | |
Lundberg et al. [59] | Sweden | Case series (N = 5) | Monotherapy or add-on therapy; 17.5 mg transdermal patches × 3 weeks, then 2 mg chewing gums × 5 weeks | Y-BOCS, NIMH-GOCS, BAI, BDI, GAF | 5 DSM-IV OCD outpatients. ↓ Y-BOCS total score (26.63%) and obsession and compulsion subscale scores, as well as ↓ NIMH-OCS scores, in 3/5 (60%) patients. ↓ BAI and BDI scores. ↑ GAF scores (7.84%) after 15 weeks | |
Pasquini et al. [75] | Italy | Case report (N = 1) | Add-on therapy; 4 mg chewing gums × 4 months | Y-BOCS, CGIs | 1 DSM-IV-TR OCD outpatient. ↓ Y-BOCS total score (39.50%) and obsession and compulsion subscale scores. ↓ CGIs scores (= 2) | |
Evaluation of cognition, but providing data on OCD symptoms | ||||||
Caldirola et al. [28] | Italy | Cross-sectional (N = 40) comparison of smokers (N = 20) vs. nonsmokers (N = 20) | Usual smoking habits (cigarettes or no nicotine intake); all 40 patients were on SSRIs, tricyclic antidepressants, and/or antipsychotic drugs | Y-BOCS, CANTAB | 40 DSM-IV-TR OCD inpatients. No difference in Y-BOCS and CANTAB scores between smokers and nonsmokers. The longer-term smokers had more cognitive impairment |