Author (year, location) | Age (years) mean (SD) | Gender M/F | Number of subjects (I/C) | Diagnosis | Intervention methods & delivery (treated acupoints) | Type of control | Outcome measures used for meta-analysis | Report of side effect |
---|---|---|---|---|---|---|---|---|
Che, (2015, China) | 43.2 (7.8) | 32/48 | 80 (40/40) | GAD (CCMD-3) | Acupuncture Duration: 6Â weeks Acupoints: Baihui, Shangxing, Shenting, Shuigou, Tanzhong, Juque, and Zhongwan | Medication: Paroxetine 20Â mg/d, 6Â weeks | Anxiety (HAMA) | TESS I: 6 cases C: 12 cases |
Cheng et al. (2018, China) | I: 36.5 (8.6) C: 35.8 (7.9) | I: 19/14 C: 20/13 | 66 (33/33) | GAD (CCMD-3) | Acupuncture plus medication (Buspirone, same dose with control) Duration: 4 Weeks Acupoints: Baihui, Sishencong, Touwei, Shenmen, Neiguan, Shousanli, Sanyinjiao, and Yanglingquan | Medication: Buspirone 20Â mg-30Â mg/d 4Â weeks | Anxiety (HAMA) | NR |
Li et al. (2015, China) | I: 67(6.4) C: 69 (8.7) | I: 15/6 C: 17/7 | 45 21/24 | GAD (CCMD-3) | Acupuncture Duration: 6 weeks Aucpoints: Laogong, Hegu, Neiguan, Shenmen, and Sanyinjiao | Medication: Lorazepam, 1.5 -3 mg/d Duration: 6 weeks | Anxiety (HAMA) | I < C |
Liu et al. (2007, China) | 38.48 (15.80) | 30/56 | 86 29/28/29 | GAD (CCMD-3) | Acupuncture Duration: 6 weeks Acupoints: Sishenzhen, Dingsehnzhen, Neiguan, Shenmen, and Sanyinjiao | C1*: medication: Paroxetine, 20 mg/d or fluoxetine 20 mg/d; or Alprazolam 0.4–1.6 mg/d C2: Acupuncture plus medication (dose same with C1) | Anxiety (HAMA) | TESS I < C2 < C1 |
Mak et al. 2019 (Hongkong, China) | I: 50.85 (11.57) C: 50.83 (14.15) | I: 20/20 C: 18/22 | 80 40/40 | GAD (DSM-5) | Electroacupuncture Duration: 10Â weeks Acupoint pairs: bilateral Neiguan and Shenmen, bilateral Zusanli and Shangjuxu, bilateral Sanyinjiao and LR3Taichong, and left Baihui and Yintang | Sham electroacupuncture; Utilize same acupoints with intervention group Duration: 10Â weeks | Anxiety (7-item Patient Health Questionnaire section for anxiety); Depression (9-item Patient Health Questionnaire, PHQ-9) | NR |
Wang et al. (2003, China) | I: 38.2 (9.4) C: 35.7 (8.8) | I: 7/13 C: 8/11 | 39 20/19 | GAD (CCMD-3) | Electroacupuncture Duration: 6 weeks Acupoints: Yintang, Baihui, Xuanlu, and Fengchi | Medication: Trazodone Hydrochloride, 100–150 mg/d, Duration: 6 weeks | Anxiety (HAMA); Depression (SDS) | NR |
Wang et al. (2005, China) | NR | NR | 65 35/30 | GAD (CCMD-3) | Acupuncture Duration: 30 days Acupoints: Yintang, Baihui, Neiguan, Shenmen, Tanzhong, and Sanyinjiao | Medication: Clomipram 0.5–2 mg, twice or three times a day, supplemented with Oryzanol 20 mg, three times a day, or Propranolol 10–20 mg, three times a day; Duration: 30 days | Anxiety (SAS) | NR |
Wang (2007, China) | I, 18–63 C: 18–64 | I: 9/12 C: 8/12 | 41 21/20 | GAD (CCMD-3) | Acupuncture Duration: 30 days Acupoints: Bihui, Yintang, Shenmen, and Sanyinjiao | Medication: Deanxit, 2 tablets /d; Duration: 30 days | Anxiety (HAMA) | NR |
Wang et al. (2010, China) | 28–65 | I: 11/19 C: 9/21 | 60 30/30 | GAD (CCMD-3) | Acupuncture Duration: 3 weeks Acupoints: Xinyu, Ganyu, Danyu, Geyu, and Shenyu | Medication: Alprazolam, 0.4–0.8 mg/d Duration: 3 weeks | Anxiety (HAMA) | NR |
Xiong, (2013, China) | 16–55 | 32/39 | 71 36/35 | GAD (CCMD-3) | Acupuncture Duration: 30 days Acupoints: Guanyuan, Zhongwan, Zhenwei, Tanzhong, Chengjiang, Baihui, Shenting, Fengfu, Dazhui, Zhiyang, and Mingmen | Medication: Deanxit, 2 tablets /d; and Oryzanol 30 mg/d Duration: 30 days | Anxiety (SAS) | NR |
Xu et al. (2012, China) | I: 38(7.5) C: 39(8.4) | I: 12/20 C: 10/20 | 62 32/30 | GAD (CCMD-3) | Acupuncture plus Chinese traditional medicine (dose was the same with the control group) Duration: 6Â weeks Acupoints: Baihui, Sishencong, Yinquexue, Neiguan, Sanyinjiao, Hegu, and Taichong | Chinese traditional medicine: Shugan Qingre recipe: Chaihu, Huaimai, liquorice, rose, cicada clothing, and Scutellaria; One dose/d; Duration: 6Â weeks | Anxiety (HAMA) | NR |
Xu et al. (2016, China) | I, 25–60 C: 23–61 | I: 14/16 C: 18/12 | 60 30/30 | GAD (CCMD-3) | Acupuncture (Yu's scalp needle) Duration: 4 weeks Acupoint: the emotional areas, which are from the fontanelle to the shenting and its parallel lines of 1 inch and 2 inch to the left and right, respectively | Medication: Buspirone, 20–40 mg/d, 4 weeks | Anxiety (HAMA) | NR |
Yan (2018, China) | I, 42.5 (4.2) C: 42.2 (4.0) | I: 13/17 C: 11/19 | 60 30/30 | GAD (CCMD-3) | Acupuncture combined with self-acupoint massage Duration: 1Â month Acupoints: Minghuangxue, Tianhuangxue, Qihuangxue, Baihui, and Yintang | Self-acupoint massage therapy: To press Fengchi point with both thumbs, temple point with left thumbs, Zhongwan point, Neiguan point, Qihai point, Tanzhong point with right thumbs, Baihui Point with right middle fingers. All the above acupoints were massaged by finger Duration: 1Â month | Anxiety (HAMA) | NR |
Zhang (2001, China) | 16–60 | 160/130 | 296 157/139 | GAD (CCMD-3) | Acupuncture Duration: 30 days Acupoints: Baihui, Neiguan, Renzhong, Sanyinjiao, and Beiyu | Medication: Doxepin, 150 mg/d; Duration: 30 days | Anxiety (SAS) | NR |
Zhang et al. (2010, China) | I: 45.69 (5.54) C: 46.90 (5.89) | I:83/103 C:61/103 | 325 186/139 | GAD (CCMD-3) | Acupuncture Duration: 4 weeks Acupoints: Three Huang Points of DONG’s extra-points (Minghuang, Tianhuang and Qihuang) | Medication: Buspirone, 15 mg/d; Duration: 4 weeks | Anxiety (HAMA) | I:1.6% C:33.8% |
Zhao et al. (2014, China) | I: 42.31 (8.44) C: 41.5 (7.89) | I: 11/19 C: 13/17 | 60 30/30 | GAD (CCMD-3) | Acupuncture Duration: 6Â weeks Acupoints: Sishen, Congtou, Baihui, Shenting, Shuigou, Bneshen, Fengchi (bilateral), Neiguan (bilateral), and Shenmen (bilateral) | Medication: Fluoxetine, 20Â mg/d; Duration: 6Â weeks | Anxiety (HAMA) | TESS I: 2 cases C: 8 cases |
Zhao et al. (2018, China) | I: 42.59 (8.17) C: 43.31 (7.96) | I:20/35 C:23/36 | 112 53/59 | GAD (CCMD-3) | Acupuncture Duration: 6Â weeks Acupoints: Yintang, Baihuim Fengchi, Neiguan, Sanyinjiao, and Taichong | Medication: Buspirone, 15Â mg/d; Duration: 6Â weeks | Anxiety (HAMA) | I: 3 cases C: 9 cases |
Zheng et al. (2004, China) | I: 35 (5.2) C: 34(6.1) | I: 13/45 C:15/35 | 108 58/50 | GAD (CCMD-3) | Acupuncture Duration: 8 weeks Acupoints: Xinyu, Jueyinyu, Baihui, Shenting, and Shenmen | Medication: Alprazolam, 0.4–0.8 mg/d; Duration: 8 weeks | Anxiety (HAMA) | I < C |
Zheng et al. (2014, China) | I: 17–56 C: 22–53 | I: 12/18 C: 9/21 | 60 30/30 | GAD (CCMD-3) | Acupuncture Duration: 4 weeks Acupoints: Xinyu, Jueyinyu, Feiyu, Ganyu, Danyu,Weiyu, Piyu, Sanjiaoyu, Shenyu, and Baihui | Auricular point sticking therapy: Duration: 4 weeks | Anxiety (SAS) | NR |
Zhou et al. (2013, China) | I: 38 (8) C: 38 (10) | I: 16/24 C18/22 | 80 40/40 | GAD (CCMD-3) | Acupuncture Duration: 6 weeks Acupoints: Lieque, Hegu, Shenmen, Houxi, Waiguan, laogong, Yongquan, Zhibian, Yinlingquan, Zusanli, Taichong, and Yanglingquan | Medication: Clonazepam, 4–8 mg/d; Duration: 6 weeks | Anxiety (HAMA) | NR |