Systematic review of gut microbiota and attention-deficit hyperactivity disorder (ADHD)

Sukmajaya, Alverina Cynthia; Lusida, Maria Inge; Soetjipto; Setiawati, Yunias

doi:10.1186/s12991-021-00330-w

Annals of General Psychiatry

Table 2 Study population methodology

From: Systematic review of gut microbiota and attention-deficit hyperactivity disorder (ADHD)

No.	Study	Genetic analysis	Characteristic of population
No.	Study	Genetic analysis	Medical history	Antibiotic usage	Probiotic/prebiotic usage	ADHD medication	Dietary patterns
1.	Aarts et al. [12]	16S rRNA gene sequencing using Titanium sequencing chemistry	No information	No information	No information	No information	No information
		Region: V3–V4
		Pipeline analysis: QIIME ver 1.2
		Database: ENA
2.	Jiang et al. [9]	16s rRNA gene pyrosequencing using Illumina MiSeq platform with TruSeqTM DNA Sample Prep Kit	Excluded sample with digestive symptoms, depressive and anxiety symptoms, obesity, atopic diseases (allergic rhinitis, asthma, eczema), and other severe diseases 2 months prior to samples collection	No use of antibiotics 2 months prior to samples collection	No use of probiotic/prebiotic 2 months prior to samples collection	No history of ADHD medication	Excluded vegetarian and non-vegetarian diet (using questionnaire filled by parents)
		Region: V3–V4
		Pipeline analysis: QIIME
3.	Prehn-Kristensen et al. [14]	DNA amplification on primer 27F-338R using Illumina Miseq	No information	No information	No information	10 samples of ADHD had been taking ADHD medication for more than a year	The participants took notes on their food intake for fast food, meat/sausage/cold cuts, fruits/vegetables, and yoghurt/dairy products (using 4-point scales)
		Region: V1–V2
		Pipeline analysis: Mothur
4.	Wang et al. [10]	16S rRNA gene sequencing	Excluded samples with history of neuropsychiatry disorder or any major diseases	No recent use of antibiotic	No recent use of antibiotic	No history of ADHD medication	Excluded vegetarian diet (using FFQ)
4.	Wang et al. [10]	Region: V3–V4		No recent use of antibiotic	No recent use of antibiotic	No history of ADHD medication	Excluded vegetarian diet (using FFQ)
5.	Wan. et al. [11]	Shotgun metagenomic sequencing using Illumina Novaseq platform	Excluded samples with history of respiratory/digestive infection in a month prior to samples	No information	No use of probiotic 1 month prior to samples collection	No information	Excluded vegetarian diet. The participants were asked to maintain their regular dietary patterns for 1
		Pipeline analysis: HUMAnN2 ver 0.11.2
		Database: Integrated Gene Catalog and KEGG	Collection, history of digestive/chronic diseases, BMI < 20 kg/m², and allergic rhinitis/asthma				Week prior to samples collection (using food diary)
6.	Szopinska-Tokov. et al. [13]	16s rRNA gene sequencing	No information	No recent use of antibiotic	No recent use of probiotic	There were history of ADHD medication	No information
		Region: 27F-DegS-338RI-II
		Pipeline analysis: NG-Tax 16s rRNA
		Database: SILVA

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ISSN: 1744-859X

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