Table 2 Comparison of neuropsychological tests between normal controls and FEDN schizophrenia (between sex)
Cognitive domains | Cognitive tests | Normal controls | FEDN schizophrenia | Diagnosis F (p-value) | Sex F (p-value) | Diagnosis × sex F (p-value) | ||
|---|---|---|---|---|---|---|---|---|
Male(n = 74) | Female(n = 86) | Male(n = 45) | Female(n = 48) | |||||
Speed of processing | Category fluency | 56.8 ± 13.1 | 52.0 ± 12.2 | 52.8 ± 9.2 | 51.5 ± 9.7 | 2.241(0.136) | 3.977(0.047) | 1.346(0.247) |
Symbol coding | 57.7 ± 9.4* | 55.9 ± 11.6 | 38.4 ± 11.0*++ | 43.5 ± 9.7++ | 132.753(< 0.001) | 1.447(0.230) | 6.354(0.012) | |
Trail Making A | 56.4 ± 8.2 | 53.8 ± 9.6 | 45.5 ± 6.8++ | 47.3 ± 7.3++ | 64.223(< 0.001) | 0.151(0.698) | 4.043(0.045) | |
Attention | CPT-IP | 55.2 ± 7.9 | 53.5 ± 8.6 | 40.4 ± 9.7++ | 44.3 ± 9.5++ | 108.633(< 0.001) | 0.845(0.359) | 6.079(0.014) |
Working memory | Spatial span total | 60.7 ± 11.4 | 55.1 ± 11.9 | 43.7 ± 12.1++ | 48.1 ± 13.2++ | 58.608(< 0.001) | 0.170(0.681) | 10.297(0.002) |
Digital sequence | 60.2 ± 10.5 | 54.4 ± 10.5 | 46.0 ± 10.2*++ | 50.8 ± 10.1 | 43.065(< 0.001) | 0.138(0.711) | 14.873(< 0.001) | |
Verbal learning | HVLT-R total | 59.8 ± 8.8 | 56.3 ± 10.3 | 46.7 ± 12.5*++ | 52.3 ± 9.3+ | 41.215(< 0.001) | 0.654(0.419) | 11.823(0.001) |
Visual learning | BVMT-R total | 57.8 ± 8.2* | 54.8 ± 10.4 | 49.1 ± 9.5++ | 46.1 ± 10.0++ | 49.165(< 0.001) | 5.762(0.017) | 0.000(0.994) |
Reasoning and problem solving | Mazes (NAB) total | 62.4 ± 7.7** | 56.4 ± 11.0 | 48.9 ± 10.3++ | 46.6 ± 9.6++ | 83.328(< 0.001) | 10.701(0.001) | 2.130(0.146) |
Social cognition | MSCEIT | 51.8 ± 8.8 | 51.0 ± 8.3 | 47.7 ± 11.9+ | 51.2 ± 11.1 | 2.432(0.120) | 1.112(0.293) | 2.740(0.099) |
Total MCCB scores | 63.0 ± 10.6 | 57.2 ± 12.4 | 44.2 ± 10.0++ | 47.6 ± 9.7++ | 97.977(< 0.001) | 0.665(0.416) | 10.234(0.002) | |