Effects of comorbid alcohol use disorder on the clinical outcomes of first-episode schizophrenia: a nationwide population-based study

Table 1 Demographic and clinical characteristics of the study population

Variable	Schizophrenia with AUD (n = 1598)	Matched controls (n = 1598)	p-value
Onset age for schizophrenia, mean (SD), years	44.3 (12.2)	44.2 (12.4)	0.873
Onset age for comorbid AUD, mean (SD), years	46.1 (12.1)	NA
Sex, n (%)			1.000
Male	1200 (75.1)	1199 (75.0)
Female	398 (24.9)	399 (25.0)
Observation period, mean (SD), years	5.1 (2.5)	5.1 (2.5)	0.941
Total duration of antipsychotic treatment, mean (SD), years	2.6 (2.2)	3.5 (2.5)	< 0.001
Duration of the first antipsychotic treatment, mean (SD), days	202.6 (337.8)	344.0 (507.9)	< 0.001
Number of antipsychotic drugs in the total observation period, mean (SD)	4.0 (2.0)	3.4 (1.9)	< 0.001
Number of the treatment discontinuations^a in the total observation period, mean (SD)	3.4 (3.0)	2.6 (2.9)	< 0.001

AUD alcohol use disorder, SD standard deviation, NA not applicable
^aDefined as no antipsychotic prescription within 28 days from the expected date of the next prescription

ISSN: 1744-859X