Table 4 Pharmacodynamic (A) and pharmacokinetic (B) gene variations

(A)

SLC6A4

(rs63749047;

rs25531)

S/S

[Low activity]

MTHFR

(rs1801133;

rs1801131)

C677T: C/T

A1298C: A/C

[Low to intermediate activity]

ADRA2A

(rs1800544)

C/G

[Improved response]

HTR2A

(rs7997012)

G/A

[Normal response]

BDNF

(rs6265)

Val/Val

[Normal activity]

COMT

(rs4680)

Val/Met

[Normal activity]

HLA-A *31:01

Negative

[Normal]

HLA-B *15:02

Negative

[Normal]

DRD2

(rs1799732)

C/C

[Normal activity]

MC4R

(rs489693)

C/A

[Normal activity]

5HT2C

(rs3813929)

C/C

[Standard weight gain risk]

ANK3

(rs10994336)

C/C

[Normal activity]

CACNA1C

(rs1006737)

G/G

[Normal activity]

OPRM1

(rs1799971)

A/A

[Normal activity]

GRIK1

(rs2832407)

A/A

[Normal activity]

GABRA6

(rs3219151)

T/T

[Increased risk]

GABRP

(rs10036156)

T/T

[Increased risk]

(B)

CYP2B6

*4/*5

RM

[High activity]

CYP2C19

*1/*17

RM

[High activity]

CYP2D6

*2/*4

IM

[Intermediate activity]

UGT2B15

(rs1902023)

*2/*2

IM

[Decreased activity]

CYP1A2

*1A/H8

EM

[Normal activity]

CYP2C9

*1/*1

EM

[Normal activity]

CYP3A4

*1/*1

EM

[Normal activity]

UGT1A4

(rs2011425)

*1a/*1a

EM

[Normal activity]

ABCB1

(rs2032583)

A/A

[Normal activity]

ABCB1

(rs1045642)

G/G

[Normal activity]