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Table 1 Genotype and allele distribution of the rs 1049353CNR1 and rs 324420FAAH variations in healthy volunteers and mean and standard deviation of LDAEP score and concentration of the endocannabinoids (AEA, 2AG and totalAG) for the genotype and allele distribution

From: Endocannabinergic modulation of central serotonergic activity in healthy human volunteers

 

Genotype

Group of genotype

GG

GA

AA

GG

GA + AA

CNR1 (rs1049353)

     

 N (%)

27 (40.5)

30 (54.8)

2 (4.7)

27 (40.5)

32 (59.5)

 LDAEP

(Mean, SD)

0.223 ± 0.12

0.272 ± 0.17

0.347 ± 0.93

0.223 ± 0.12

0.277 ± 0.17

 AEA (nmol/L)

(Mean, SD)

0.71 ± 0.23

0.65 ± 0.20

0.51 ± 0.08

0.71 ± 0.23

0.64 ± 0.24

 2AG (nmol/L)

(Mean, SD)

1.02 ± 0.82

0.66 ± 0.24

0.78 ± 0.16

1.02 ± 0.82

0.66 ± 0.24

 TotalAG (nmol/L)

(Mean, SD)

2.88 ± 3.02

1.50 ± 0.46

1.94 ± 0.59

2.88 ± 3.02

1.53 ± 0.47

 

CC

CA

AA

CC

CA + AA

FAAH (rs324420)

     

 N (%)

44 (75.5)

13 (21.2)

2 (3.3)

44 (75.5)

15 (25)

 LDAEP

(Mean, SD)

0.255 ± 0.16

0.243 ± 0.12

0.247 ± 0.09

0.255 ± 0.16

0.243 ± 0.11

 AEA (nmol/L)

(Mean, SD)

0.64 ± 0.21

0.74 ± 0.17

0.90 ± 0.55

0.64 ± 0.21

0.76 ± 0.22

 2AG (nmol/L)

(Mean, SD)

0.76 ± 0.46

1.08 ± 0.90

0.42 ± 0.26

0.76 ± 0.46

0.99 ± 0.87

 TotalAG (nmol/L)

(Mean, SD)

2.01 ± 1.62

2.67 ± 3.49

1.40 ± 0.62

2.01 ± 1.62

2.50 ± 3.27