From: Endocannabinergic modulation of central serotonergic activity in healthy human volunteers
Genotype | Group of genotype | ||||
---|---|---|---|---|---|
GG | GA | AA | GG | GA + AA | |
CNR1 (rs1049353) | |||||
N (%) | 27 (40.5) | 30 (54.8) | 2 (4.7) | 27 (40.5) | 32 (59.5) |
LDAEP (Mean, SD) | 0.223 ± 0.12 | 0.272 ± 0.17 | 0.347 ± 0.93 | 0.223 ± 0.12 | 0.277 ± 0.17 |
AEA (nmol/L) (Mean, SD) | 0.71 ± 0.23 | 0.65 ± 0.20 | 0.51 ± 0.08 | 0.71 ± 0.23 | 0.64 ± 0.24 |
2AG (nmol/L) (Mean, SD) | 1.02 ± 0.82 | 0.66 ± 0.24 | 0.78 ± 0.16 | 1.02 ± 0.82 | 0.66 ± 0.24 |
TotalAG (nmol/L) (Mean, SD) | 2.88 ± 3.02 | 1.50 ± 0.46 | 1.94 ± 0.59 | 2.88 ± 3.02 | 1.53 ± 0.47 |
CC | CA | AA | CC | CA + AA | |
---|---|---|---|---|---|
FAAH (rs324420) | |||||
N (%) | 44 (75.5) | 13 (21.2) | 2 (3.3) | 44 (75.5) | 15 (25) |
LDAEP (Mean, SD) | 0.255 ± 0.16 | 0.243 ± 0.12 | 0.247 ± 0.09 | 0.255 ± 0.16 | 0.243 ± 0.11 |
AEA (nmol/L) (Mean, SD) | 0.64 ± 0.21 | 0.74 ± 0.17 | 0.90 ± 0.55 | 0.64 ± 0.21 | 0.76 ± 0.22 |
2AG (nmol/L) (Mean, SD) | 0.76 ± 0.46 | 1.08 ± 0.90 | 0.42 ± 0.26 | 0.76 ± 0.46 | 0.99 ± 0.87 |
TotalAG (nmol/L) (Mean, SD) | 2.01 ± 1.62 | 2.67 ± 3.49 | 1.40 ± 0.62 | 2.01 ± 1.62 | 2.50 ± 3.27 |