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Table 4 Adjusted HRQoL

From: The economic and humanistic burden of bipolar disorder in adults in the United States

Outcome

Respondents with bipolar disorder by depressive symptom severity

Respondents with bipolar disorder (n = 3285)

General population (n = 6570)

None/mild (n = 1401)

Moderate (n = 889)

Severe (n = 1293)

EQ-5D, mean (95% CI)

0.77 (0.76, 0.78)

0.67 (0.66, 0.68)

0.59 (0.58, 0.60)

0.69 (0.68, 0.69)

0.79 (0.79, 0.80)

EQ-5D VAS, mean (95% CI)

70.9 (69.6, 72.3)

62.1 (60.3, 63.8)

56.1 (54.6, 57.5)

63.8 (63.0, 64.7)

71.7 (71.1, 72.3)

SF-36 MCS, mean (95% CI)

42.0 (41.5, 42.5)

35.1 (34.5, 35.8)

28.1 (27.6, 28.6)

35.4 (35.0, 35.8)

42.0 (41.7, 42.3)

SF-36 PCS, mean (95% CI)

48.7 (48.2, 49.2)

44.9 (44.3, 45.6)

44.4 (43.9, 45.0)

46.5 (46.2, 46.9)

49.6 (49.3, 49.8)

SF-6D, mean (95% CI)

0.65 (0.65, 0.66)

0.57 (0.57, 0.58)

0.53 (0.52, 0.54)

0.59 (0.59, 0.60)

0.67 (0.66, 0.67)

  1. BMI, body mass index; CCI, Charlson Comorbidity Index; CI, confidence interval; EQ-5D, EuroQol 5-Dimension Health Questionnaire; MCS, mental component summary; n, number of respondents; PCS, physical component summary; SF-36, Medical Outcomes Study 36-Item Short Form Survey Instrument; VAS, visual analog scale
  2. Models by depressive symptom severity adjusted for age, sex, race, employment, health insurance, smoking status, alcohol use, exercise behavior, BMI, education level, income level, and CCI. Models comparing respondents with bipolar disorder vs. matched general population adjusted for CCI