Histamine and its receptors were first described as part of immune and gastrointestinal systems, but their presence in the central nervous system and importance in behavior are gaining more attention. The hist...
Authors: Diego Baronio, Taylor Gonchoroski, Kamila Castro, Geancarlo Zanatta, Carmem Gottfried and Rudimar Riesgo
Gender differences in post-traumatic stress disorder (PTSD) rates were confirmed across different DSM editions as well as the role of bipolar disorder (BD) comorbidity on prevalence and course, but little data...
Authors: Claudia Carmassi, Paolo Stratta, Gabriele Massimetti, Carlo Antonio Bertelloni, Ciro Conversano, Ivan Mirko Cremone, Mario Miccoli, Angelo Baggiani, Alessandro Rossi and Liliana Dell'Osso
The present study aims to examine if autism spectrum disorder (ASD) is a risk factor for suicide attempts among adult depressed patients and to elucidate the characteristics of suicide attempts in adult depres...
Nonconvulsive status epilepticus (NCSE) is a severe medical condition and heterogeneous disorder defined by different seizure types and diverse etiologies. NCSE occurs commonly in the elderly and is potentiall...
Authors: Kazuhiko Yamamuro, Hiroki Yoshino, Kentaro Tamura, Toyosaku Ota and Toshifumi Kishimoto
Detecting psychiatric disorders of secondary origin is a crucial concern for the psychiatrist. But how can this reliably be done among a large number of conditions, most of which have a very low prevalence? Me...
Although a plethora of studies have delineated the relationship between childhood trauma and onset, symptom severity, and course of depression and anxiety disorders, there has been little evidence that childho...
Authors: Hyu Jung Huh, Sun-Young Kim, Jeong Jin Yu and Jeong-Ho Chae
Cognitive remediation therapy (CRT) for anorexia nervosa (AN) is an intervention designed to improve the thinking processes of AN patients as well as their general cognitive functioning. While previous behavio...
Authors: Leon Fonville, Vincent Giampietro, Helen Davies, Naima Lounes, Andrew Simmons, Steven Williams and Kate Tchanturia
Autism spectrum disorder is a neurodevelopmental disorder characterized by impairments in social interactions, reduced verbal communication abilities, stereotyped repetitive behaviors, and restricted interests...
Site-independent review of subject eligibility for central nervous system (CNS) trials has been used as a surveillance method to enhance the integrity and precision of the subject selection process. We evaluated ...
We investigated the association between serum proBDNF, a precursor of brain-derived neurotrophic factor (BDNF), and response to fluvoxamine in patients with major depressive disorder (MDD) using the Diagnostic...
Authors: Reiji Yoshimura, Taro Kishi, Hikaru Hori, Kiyokazu Atake, Asuka Katsuki, Wakako Nakano-Umene, Atsuko Ikenouchi-Sugita, Nakao Iwata and Jun Nakamura
Neuregulins are a family of signalling proteins that orchestrate a broad range of cellular responses. Four genes encoding Neuregulins 1–4 have been identified so far in vertebrates. Among them, Neuregulin 1 an...
Authors: Álvaro Díez, Clara Cieza-Borrella, Vanessa Suazo, Rogelio González-Sarmiento, Sergi Papiol and Vicente Molina
Although there is a wide variety of antidepressants with different mechanisms of action available, the efficacy of treatment is not satisfactory. Genetic factors are presumed to play a role in differences in m...
Authors: Dávid Kovacs, Xénia Gonda, Péter Petschner, Andrea Edes, Nóra Eszlari, György Bagdy and Gabriella Juhasz
The early contributions of childhood trauma (emotional, physical, sexual, and general) have been hypothesized to play a significant role in the development of anxiety disorders, such as posttraumatic stress di...
Authors: Melanie Bishop, David Rosenstein, Susanne Bakelaar and Soraya Seedat
Facial emotion perception (FEP) can affect social function. We previously reported that parts of five tested single-nucleotide polymorphisms (SNPs) in the MET and AKT1 genes may individually affect FEP perform...
Authors: Li-Yeh Chuang, Hsien-Yuan Lane, Yu-Da Lin, Ming-Teng Lin, Cheng-Hong Yang and Hsueh-Wei Chang
During the last few years, many countries in Europe suffered from a severe economic crisis which resulted in high unemployment rates. In this frame, the possible relationship between unemployment rate and suic...
Authors: Konstantinos N Fountoulakis, Xenia Gonda, Peter Dome, Pavlos N Theodorakis and Zoltan Rihmer
From the ancient times, there are three basic approaches for the interpretation of the different psychic phenomena: the organic, the psychological, and the sacred approach. The sacred approach forms the primor...
Authors: Georgios Tzeferakos and Athanasios Douzenis
Many patients with schizophrenia receive long-term treatment with antipsychotic medication. Switching of antipsychotic medication due to lack of efficacy, tolerability issues, and partial/non-adherence is comm...
Authors: Joseph Peuskens, Gabriel Rubio and Andreas Schreiner
In Japan, new legislation regarding forensic mental health, namely, the Act on Medical Care and Treatment for Persons Who Have Caused Serious Cases under the Condition of Insanity (Medical Treatment and Superv...
Authors: Akihiro Shiina, Masaomi Iyo, Akira Yoshizumi and Naotsugu Hirabayashi
The objective of this research was to examine treatment patterns and health-care costs associated with second-step pharmacotherapy in patients with major depressive disorder (MDD) who initiated monotherapy wit...
Authors: Susan Ball, Peter Classi and Ellen B Dennehy
Many studies have shown that the prevalence of smoking in schizophrenia is higher than in the general population. Biological, psychological and social factors influence smoking in patients with schizophrenia.
Authors: Hiranya Wijesundera, Raveen Hanwella and Varuni A de Silva
Internet addiction (IA) is considered as one of behavioral addictions. Although common neurobiological mechanisms have been suggested to underlie behavioral addiction and substance dependence, few studies have...
Authors: Jae Yeon Hwang, Jung-Seok Choi, Ah Reum Gwak, Dawn Jung, Sam-Wook Choi, Jaewon Lee, Jun-Young Lee, Hee Yeon Jung and Dai Jin Kim
It has been suggested that interpersonal sensitivity, a personality trait associated with depression and anxiety disorders, is linked with attachment insecurity. To confirm this link, we studied the correlatio...
Acute and transient psychotic disorder (ATPD) has been described as an acute psychosis with brief onset and polymorphous symptomatology (WHO, 1993). The study of ATPD is growing increasingly relevant as scient...
Courses such as Mental Health First Aid equip members of the public to perform appropriate helping behaviours towards people experiencing a mental illness or mental health crisis. However, studies investigatin...
Authors: Alyssia Rossetto, Anthony F Jorm and Nicola J Reavley
Early childhood education services create potentially optimal opportunities to identify and respond effectively to preschoolers' mental health problems. However, little is known about the knowledge, skills and...
Authors: George Giannakopoulos, Eirini Agapidaki, Christine Dimitrakaki, Despoina Oikonomidou, Dimitra Petanidou, Lia Tsermidou, Gerasimos Kolaitis, Yannis Tountas and Kalliroi Papadopoulou
Patients under antipsychotic treatment for schizophrenia commonly exhibit poor adherence to treatment, high rates of treatment discontinuation, and frequent treatment changes. The ETOS study aimed to identify ...
Authors: Andreas Roussidis, Christina Kalkavoura, Dimos Dimelis, Afroditi Theodorou, Ina Ioannidou, Eleytherios Mellos, Triantafyllia Mylonaki, Areti Spyropoulou and Andreas Yfantis
Patient satisfaction is an important outcome variable that is increasingly used in mental health service evaluation. There are no results available for patients with obsessive-compulsive disorder (OCD) yet.
Authors: Paraskevi Mavrogiorgou, Frauke Siebers, Georg Juckel and Thorsten Kienast
Patients with schizophrenia often experience comorbid obsessive-compulsive symptoms. Within these patients, a significant subgroup developed secondary obsessive-compulsive symptoms during treatment with clozap...
Authors: Gül Eryılmaz, Gökben Hızlı Sayar, Eylem Ozten, Işıl Gögcegöz Gül and Oğuz Karamustafalıoğlu
Type D personality has been associated with a variety of emotional and social difficulties as well as with poor prognosis in patients with established coronary heart disease (CHD). We examined the psychometric...
Authors: Christos Christodoulou, Athanasios Douzenis, Paula MC Mommersteeg, Loukianos Rallidis, Antonis Poulios, Vasiliki Efstathiou, Georgios Bouras, Christos Varounis, Panagiota Korkoliakou, John Palios, Dimitrios Th Kremastinos and Lefteris Lykouras
Maternal depression has a negative impact on both the mother and child's physical and mental health, as well as impairs parenting skills and pediatric health care utilization. The pediatricians' role in identi...
Authors: Eirini Agapidaki, Kyriakos Souliotis, Stylianos Christogiorgos, lannis Zervas, Angeliki Leonardou, Gerasimos Kolaitis, George Giannakopoulos, Christina Dimitrakaki and Yannis Tountas
Whether depression or cardiovascular disease would have a greater effect on worsening cognitive impairment in the burgeoning older elderly population is uncertain. Which disorder causes greater cognitive impai...
Authors: Yun-Hsuan Chang, Mu-En Liu, Chih-Chun Huang, Yan-Chiou Ku, Sheng-Yu Lee, Shiou-Lan Chen, Wen-Chien Liu and Ru-Band Lu
In South Korea, it has not been easy to negotiate studies that target drug users who are being punished by law, and accordingly, no study on suicidal ideation among substance users has been accomplished yet. I...
Authors: Min Kwon, Soo Yang, Kyongran Park and Dai-Jin Kim
Adolescence represents one of the critical transitions in the life span and is characterized by a tremendous pace in growth and change that is second only to that of infancy. Both biological and psychological ...
Authors: Concetta De Pasquale, Maria Luisa Pistorio, Eleonora Tornatore, Domenico De Berardis and Michele Fornaro
Several studies have reported significantly higher stress levels, both short and long terms, among mothers giving preterm birth compared with mothers giving birth at term. Stress, however, is a psychological p...
Authors: Aud R Misund, Per Nerdrum, Stein Bråten, Are Hugo Pripp and Trond H Diseth
Relapse in patients with schizophrenia has devastating repercussions, including worsening symptoms, impaired functioning, cognitive deterioration and reduced quality of life. This progressive decline exacerbat...
Authors: José M Olivares, Jan Sermon, Michiel Hemels and Andreas Schreiner
Several lines of evidence suggest that dysfunction of the dorsolateral prefrontal cortex (DLPFC) and orbitofrontal cortex (OFC) contributes to the pathophysiology of pervasive developmental disorders (PDD). Th...
Individuals with posttraumatic stress disorder (PTSD) are more likely to undertake harmful health behaviors like substance use. Less is known about the association of PTSD with healthful behaviors such as heal...
Authors: Kathryn M Godfrey, Laurie A Lindamer, Sheeva Mostoufi and Niloofar Afari
The 22q11.2 deletion syndrome is caused by a microdeletion of chromosome 22. One third of all patients with 22q11.2 deletion develop schizophrenia-like symptoms. In general, the prevalence of 22q11.2 deletion ...
The Subjective Well-Being Under Neuroleptic Treatment Scale short form (SWN-K) is a self-rating scale developed to measure mentally ill patients' well-being under the antipsychotic drug treatment. This paper r...
Authors: Liina Haring, René Mõttus, Peeter Jaanson, Raine Pilli, Kairi Mägi and Eduard Maron
Caring for individuals with schizophrenia can create distress for caregivers which can, in turn, have a harmful impact on patient progress. There could be a better understanding of the connections between care...
Authors: Shyhrete Rexhaj, Nataly Viens Python, Diane Morin, Charles Bonsack and Jérôme Favrod
During the last decade, a number of meta-analyses questioned the clinically relevant efficacy of antidepressants. Part of the debate concerned the method used in each of these meta-analyses as well as the qual...
Authors: Konstantinos N Fountoulakis, Areti Angeliki Veroniki, Melina Siamouli and Hans-Jürgen Möller
Anxiety is a major risk factor for problematic school absenteeism. However, most anxious students attend school. What differentiates anxious attenders from non-attenders?
Medically unexplained symptoms have been reported among both civilians and military personnel exposed to combat. A large number of military personnel deployed to the Gulf War in 1991 reported non-specific symp...
Authors: Varuni A de Silva, Nicholas ELW Jayasekera and Raveen Hanwella
Cushing’s syndrome can present with a spectrum of symptoms; however, it is less recognised that psychiatric symptoms can form part of the clinical presenting features. In the investigations for an organic caus...
Authors: Alice Tang, Anthony J O’Sullivan, Terry Diamond, Andrew Gerard and Peter Campbell
Increasing availability and use of long-acting injectable antipsychotics have generated a need to compare these formulations with their oral equivalents; however, a paucity of relevant data is available.
Authors: Michael Markowitz, Dong-Jing Fu, Bennett Levitan, Srihari Gopal, Ibrahim Turkoz and Larry Alphs
Annual suicide rates of Hungary were unexpectedly high in the previous century. In our narrative review, we try to depict, with presentation of the raw data, the main descriptive epidemiological features of th...
Authors: Zoltan Rihmer, Xenia Gonda, Balazs Kapitany and Peter Dome
