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  1. The purpose of the study was to examine the impact of computerized cognitive behavior therapy (CBT) self-help treatment for obsessive-compulsive disorder (OCD) (BT Steps) both alone and when supported by coach...

    Authors: Kenneth A Kobak, Revere Greist, David M Jacobi, Hollie Levy-Mack and John H Greist

    Citation: Annals of General Psychiatry 2015 14:10

    Content type: Primary research

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  3. Repetitive transcranial magnetic stimulation (rTMS) has been found to be effective in reducing frequency and duration of auditory verbal hallucinations (AVH). Priming stimulation, which involves high-frequency...

    Authors: Prasenjit Ray, Vinod Kumar Sinha and Sai Krishna Tikka

    Citation: Annals of General Psychiatry 2015 14:8

    Content type: Primary research

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  4. Dromokaition Psychiatric Hospital opened its doors in 1887, following the donation made by Zorzis Dromokaitis from the island of Chios. Private donations and all forms of charities had contributed to a large e...

    Authors: Markella Fiste, Dimitrios Ploumpidis, Costas Tsiamis, Effie Poulakou-Rebelakou and Ioannis Liappas

    Citation: Annals of General Psychiatry 2015 14:7

    Content type: Review

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  5. This study aimed to compare the performance of Positive and Negative Syndrome Scale (PANSS) symptom severity criteria established by the Remission in Schizophrenia Working Group (RSWG) with criteria based on C...

    Authors: Federica Pinna, Luca Deriu, Enrica Diana, Valeria Perra, Rachele Pisu Randaccio, Lucia Sanna, Massimo Tusconi and Bernardo Carpiniello

    Citation: Annals of General Psychiatry 2015 14:6

    Content type: Primary research

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  6. Trauma exposure depends of the type of trauma and can result in the development of posttraumatic stress disorder (PTSD). The type of traumatization (such as Holocaust experiences and other sources of trauma) a...

    Authors: Helge H Müller, Sebastian Moeller, York Hilger and Wolfgang Sperling

    Citation: Annals of General Psychiatry 2015 14:5

    Content type: Primary research

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  7. Despite the fact that smoking is a crucial morbidity factor among psychiatric patients, little progress has been made in order to reduce smoking during psychiatric hospitalization.

    Authors: Ioannis Michopoulos, Emmanouil Rizos, Rossetos Gournellis, Andromachi Karvouni, Ioanna Kotsioumpa and Athanasios Douzenis

    Citation: Annals of General Psychiatry 2015 14:4

    Content type: Primary research

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  8. Under-prescription of antidepressants (ADs) among people meeting the criteria for major depressive episodes and excessive prescription in less symptomatic patients have been reported. The reasons influencing g...

    Authors: Alain Mercier, Jacques Benichou, Isabelle Auger-Aubin, Jean-Pierre Lebeau, Estelle Houivet, Paul Van Royen and Lieve Peremans

    Citation: Annals of General Psychiatry 2015 14:3

    Content type: Primary research

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  9. This study is done to compare the effect of adjunctive therapy with pregabalin versus usual care (UC) on health-care costs and clinical and patients consequences in generalized anxiety disorder (GAD) subjects ...

    Authors: Enrique Álvarez, José M Olivares, José L Carrasco, Vanessa López-Gómez and Javier Rejas

    Citation: Annals of General Psychiatry 2015 14:2

    Content type: Review

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  10. While the frequency and importance of antipsychotic switching in patients with schizophrenia, there is insufficient evidence with regard to switching strategy. Quetiapine is one of the drugs of choice for swit...

    Authors: Naoki Hashimoto, Atsuhito Toyomaki, Minoru Honda, Satoru Miyano, Nobuyuki Nitta, Hiroyuki Sawayama, Yasufumi Sugawara, Keiichi Uemura, Noriko Tsukamoto, Tsukasa Koyama and Ichiro Kusumi

    Citation: Annals of General Psychiatry 2015 14:1

    Content type: Primary research

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  11. Alexithymia, the difficulty in describing or recognizing emotions, has been associated with various psychosomatic pathologies including psoriasis. The aim of this study was to examine the prevalence of alexith...

    Authors: Panagiota Korkoliakou, Christos Christodoulou, Anargyros Kouris, Evgenia Porichi, Vasiliki Efstathiou, Eythymia Kaloudi, Anna Kokkevi, Nikolaos Stavrianeas, Charalabos Papageorgiou and Athanasios Douzenis

    Citation: Annals of General Psychiatry 2014 13:38

    Content type: Primary research

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  12. The revised NEO Personality Inventory (NEO-PI-3) includes 240 items corresponding to the Big Five personality traits (Extraversion, Agreeableness, Conscientiousness, Neuroticism, and Openness to Experience) an...

    Authors: Konstantinos N Fountoulakis, Melina Siamouli, Stefania Moysidou, Eleonora Pantoula, Katerina Moutou, Panagiotis Panagiotidis, Marina Kemeridou, Eirini Mavridou, Efimia Loli, Elena Batsiari, Antonio Preti, Leonardo Tondo, Xenia Gonda, Nisreen Mobayed, Kareen Akiskal, Hagop Akiskal…

    Citation: Annals of General Psychiatry 2014 13:36

    Content type: Primary research

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  13. Originally developed for the treatment of epilepsy, pregabalin has become a compound with a wide spectrum of indications comprising anxiety disorders and chronic pain and is therefore largely prescribed. Thus,...

    Authors: Andreas Kustermann, Cornelia Möbius, Timo Oberstein, Helge H Müller and Johannes Kornhuber

    Citation: Annals of General Psychiatry 2014 13:37

    Content type: Case report

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  15. The relationship between substance use disorders and psychiatric pathology is still an open question. The main aim of the present study was to verify whether the five psychopathological dimensions identified t...

    Authors: Pier Paolo Pani, Emanuela Trogu, Federica Vigna-Taglianti, Federica Mathis, Roberto Diecidue, Ursula Kirchmayer, Laura Amato, Marina Davoli, Joli Ghibaudi, Antonella Camposeragna, Alessio Saponaro, Fabrizio Faggiano, Angelo Giovanni Icro Maremmani and Icro Maremmani

    Citation: Annals of General Psychiatry 2014 13:35

    Content type: Primary research

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  16. Histamine and its receptors were first described as part of immune and gastrointestinal systems, but their presence in the central nervous system and importance in behavior are gaining more attention. The hist...

    Authors: Diego Baronio, Taylor Gonchoroski, Kamila Castro, Geancarlo Zanatta, Carmem Gottfried and Rudimar Riesgo

    Citation: Annals of General Psychiatry 2014 13:34

    Content type: Review

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  17. Despite substantial research on the comorbidity of anxiety disorders including posttraumatic stress disorder (PTSD) and chronic pain, little is known about the mechanisms underlying these conditions that might...

    Authors: Sheeva Mostoufi, Kathryn M Godfrey, Sandra M Ahumada, Nazia Hossain, Titus Song, Lisa Johnson Wright, James B Lohr and Niloofar Afari

    Citation: Annals of General Psychiatry 2014 13:31

    Content type: Primary research

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  18. Gender differences in post-traumatic stress disorder (PTSD) rates were confirmed across different DSM editions as well as the role of bipolar disorder (BD) comorbidity on prevalence and course, but little data...

    Authors: Claudia Carmassi, Paolo Stratta, Gabriele Massimetti, Carlo Antonio Bertelloni, Ciro Conversano, Ivan Mirko Cremone, Mario Miccoli, Angelo Baggiani, Alessandro Rossi and Liliana Dell'Osso

    Citation: Annals of General Psychiatry 2014 13:28

    Content type: Primary research

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  19. The present study aims to examine if autism spectrum disorder (ASD) is a risk factor for suicide attempts among adult depressed patients and to elucidate the characteristics of suicide attempts in adult depres...

    Authors: Kiyoharu Takara and Tsuyoshi Kondo

    Citation: Annals of General Psychiatry 2014 13:33

    Content type: Primary research

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  20. Nonconvulsive status epilepticus (NCSE) is a severe medical condition and heterogeneous disorder defined by different seizure types and diverse etiologies. NCSE occurs commonly in the elderly and is potentiall...

    Authors: Kazuhiko Yamamuro, Hiroki Yoshino, Kentaro Tamura, Toyosaku Ota and Toshifumi Kishimoto

    Citation: Annals of General Psychiatry 2014 13:32

    Content type: Case report

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  22. Although a plethora of studies have delineated the relationship between childhood trauma and onset, symptom severity, and course of depression and anxiety disorders, there has been little evidence that childho...

    Authors: Hyu Jung Huh, Sun-Young Kim, Jeong Jin Yu and Jeong-Ho Chae

    Citation: Annals of General Psychiatry 2014 13:26

    Content type: Primary research

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  23. Cognitive remediation therapy (CRT) for anorexia nervosa (AN) is an intervention designed to improve the thinking processes of AN patients as well as their general cognitive functioning. While previous behavio...

    Authors: Leon Fonville, Vincent Giampietro, Helen Davies, Naima Lounes, Andrew Simmons, Steven Williams and Kate Tchanturia

    Citation: Annals of General Psychiatry 2014 13:25

    Content type: Primary research

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  24. Autism spectrum disorder is a neurodevelopmental disorder characterized by impairments in social interactions, reduced verbal communication abilities, stereotyped repetitive behaviors, and restricted interests...

    Authors: Yuka Yasuda, Ryota Hashimoto, Ryoko Fukai, Nobuhiko Okamoto, Yoko Hiraki, Hidenaga Yamamori, Michiko Fujimoto, Kazutaka Ohi, Masako Taniike, Ikuko Mohri, Mitsuko Nakashima, Yoshinori Tsurusaki, Hirotomo Saitsu, Naomichi Matsumoto, Noriko Miyake and Masatoshi Takeda

    Citation: Annals of General Psychiatry 2014 13:22

    Content type: Case report

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  25. Site-independent review of subject eligibility for central nervous system (CNS) trials has been used as a surveillance method to enhance the integrity and precision of the subject selection process. We evaluated ...

    Authors: Steven D Targum and J Cara Pendergrass

    Citation: Annals of General Psychiatry 2014 13:21

    Content type: Primary research

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  26. We investigated the association between serum proBDNF, a precursor of brain-derived neurotrophic factor (BDNF), and response to fluvoxamine in patients with major depressive disorder (MDD) using the Diagnostic...

    Authors: Reiji Yoshimura, Taro Kishi, Hikaru Hori, Kiyokazu Atake, Asuka Katsuki, Wakako Nakano-Umene, Atsuko Ikenouchi-Sugita, Nakao Iwata and Jun Nakamura

    Citation: Annals of General Psychiatry 2014 13:19

    Content type: Primary research

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  27. Neuregulins are a family of signalling proteins that orchestrate a broad range of cellular responses. Four genes encoding Neuregulins 1–4 have been identified so far in vertebrates. Among them, Neuregulin 1 an...

    Authors: Álvaro Díez, Clara Cieza-Borrella, Vanessa Suazo, Rogelio González-Sarmiento, Sergi Papiol and Vicente Molina

    Citation: Annals of General Psychiatry 2014 13:18

    Content type: Primary research

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  28. Although there is a wide variety of antidepressants with different mechanisms of action available, the efficacy of treatment is not satisfactory. Genetic factors are presumed to play a role in differences in m...

    Authors: Dávid Kovacs, Xénia Gonda, Péter Petschner, Andrea Edes, Nóra Eszlari, György Bagdy and Gabriella Juhasz

    Citation: Annals of General Psychiatry 2014 13:17

    Content type: Review

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  29. The early contributions of childhood trauma (emotional, physical, sexual, and general) have been hypothesized to play a significant role in the development of anxiety disorders, such as posttraumatic stress di...

    Authors: Melanie Bishop, David Rosenstein, Susanne Bakelaar and Soraya Seedat

    Citation: Annals of General Psychiatry 2014 13:16

    Content type: Primary research

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  30. Facial emotion perception (FEP) can affect social function. We previously reported that parts of five tested single-nucleotide polymorphisms (SNPs) in the MET and AKT1 genes may individually affect FEP perform...

    Authors: Li-Yeh Chuang, Hsien-Yuan Lane, Yu-Da Lin, Ming-Teng Lin, Cheng-Hong Yang and Hsueh-Wei Chang

    Citation: Annals of General Psychiatry 2014 13:15

    Content type: Primary research

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  31. Some psychotropic medications (e.g., benzodiazepines, sedative antidepressants, etc.) may impair cognitive and psychomotor functions and, therefore, endanger traffic safety (Ravera, Br J Clin Pharmacol, 72(3):...

    Authors: Francisco Alonso, Cristina Esteban, Luis Montoro and Francisco Tortosa

    Citation: Annals of General Psychiatry 2014 13:14

    Content type: Primary research

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  33. During the last few years, many countries in Europe suffered from a severe economic crisis which resulted in high unemployment rates. In this frame, the possible relationship between unemployment rate and suic...

    Authors: Konstantinos N Fountoulakis, Xenia Gonda, Peter Dome, Pavlos N Theodorakis and Zoltan Rihmer

    Citation: Annals of General Psychiatry 2014 13:12

    Content type: Primary research

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  34. From the ancient times, there are three basic approaches for the interpretation of the different psychic phenomena: the organic, the psychological, and the sacred approach. The sacred approach forms the primor...

    Authors: Georgios Tzeferakos and Athanasios Douzenis

    Citation: Annals of General Psychiatry 2014 13:11

    Content type: Review

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    The Retraction Note to this article has been published in Annals of General Psychiatry 2014 13:30

  35. Many patients with schizophrenia receive long-term treatment with antipsychotic medication. Switching of antipsychotic medication due to lack of efficacy, tolerability issues, and partial/non-adherence is comm...

    Authors: Joseph Peuskens, Gabriel Rubio and Andreas Schreiner

    Citation: Annals of General Psychiatry 2014 13:10

    Content type: Review

    Published on:

  36. In Japan, new legislation regarding forensic mental health, namely, the Act on Medical Care and Treatment for Persons Who Have Caused Serious Cases under the Condition of Insanity (Medical Treatment and Superv...

    Authors: Akihiro Shiina, Masaomi Iyo, Akira Yoshizumi and Naotsugu Hirabayashi

    Citation: Annals of General Psychiatry 2014 13:9

    Content type: Primary research

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  37. The objective of this research was to examine treatment patterns and health-care costs associated with second-step pharmacotherapy in patients with major depressive disorder (MDD) who initiated monotherapy wit...

    Authors: Susan Ball, Peter Classi and Ellen B Dennehy

    Citation: Annals of General Psychiatry 2014 13:8

    Content type: Primary research

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  38. Many studies have shown that the prevalence of smoking in schizophrenia is higher than in the general population. Biological, psychological and social factors influence smoking in patients with schizophrenia.

    Authors: Hiranya Wijesundera, Raveen Hanwella and Varuni A de Silva

    Citation: Annals of General Psychiatry 2014 13:7

    Content type: Primary research

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  39. Internet addiction (IA) is considered as one of behavioral addictions. Although common neurobiological mechanisms have been suggested to underlie behavioral addiction and substance dependence, few studies have...

    Authors: Jae Yeon Hwang, Jung-Seok Choi, Ah Reum Gwak, Dawn Jung, Sam-Wook Choi, Jaewon Lee, Jun-Young Lee, Hee Yeon Jung and Dai Jin Kim

    Citation: Annals of General Psychiatry 2014 13:6

    Content type: Primary research

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  40. It has been suggested that interpersonal sensitivity, a personality trait associated with depression and anxiety disorders, is linked with attachment insecurity. To confirm this link, we studied the correlatio...

    Authors: Koichi Otani, Akihito Suzuki, Yoshihiko Matsumoto, Naoshi Shibuya, Ryoichi Sadahiro and Masanori Enokido

    Citation: Annals of General Psychiatry 2014 13:5

    Content type: Primary research

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  43. Courses such as Mental Health First Aid equip members of the public to perform appropriate helping behaviours towards people experiencing a mental illness or mental health crisis. However, studies investigatin...

    Authors: Alyssia Rossetto, Anthony F Jorm and Nicola J Reavley

    Citation: Annals of General Psychiatry 2014 13:2

    Content type: Primary research

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  44. Early childhood education services create potentially optimal opportunities to identify and respond effectively to preschoolers' mental health problems. However, little is known about the knowledge, skills and...

    Authors: George Giannakopoulos, Eirini Agapidaki, Christine Dimitrakaki, Despoina Oikonomidou, Dimitra Petanidou, Lia Tsermidou, Gerasimos Kolaitis, Yannis Tountas and Kalliroi Papadopoulou

    Citation: Annals of General Psychiatry 2014 13:1

    Content type: Primary research

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  45. Patients under antipsychotic treatment for schizophrenia commonly exhibit poor adherence to treatment, high rates of treatment discontinuation, and frequent treatment changes. The ETOS study aimed to identify ...

    Authors: Andreas Roussidis, Christina Kalkavoura, Dimos Dimelis, Afroditi Theodorou, Ina Ioannidou, Eleytherios Mellos, Triantafyllia Mylonaki, Areti Spyropoulou and Andreas Yfantis

    Citation: Annals of General Psychiatry 2013 12:42

    Content type: Primary research

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  46. Patient satisfaction is an important outcome variable that is increasingly used in mental health service evaluation. There are no results available for patients with obsessive-compulsive disorder (OCD) yet.

    Authors: Paraskevi Mavrogiorgou, Frauke Siebers, Georg Juckel and Thorsten Kienast

    Citation: Annals of General Psychiatry 2013 12:41

    Content type: Primary research

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  47. Patients with schizophrenia often experience comorbid obsessive-compulsive symptoms. Within these patients, a significant subgroup developed secondary obsessive-compulsive symptoms during treatment with clozap...

    Authors: Gül Eryılmaz, Gökben Hızlı Sayar, Eylem Ozten, Işıl Gögcegöz Gül and Oğuz Karamustafalıoğlu

    Citation: Annals of General Psychiatry 2013 12:40

    Content type: Case report

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  48. The aim was to identify potential risk factors for lethal outcome in patients with delirium tremens (DT) treated in the psychiatric setting.

    Authors: Dragana Ignjatovic-Ristic, Nemanja Rancic, Slobodan Novokmet, Slobodan Jankovic and Srdjan Stefanovic

    Citation: Annals of General Psychiatry 2013 12:39

    Content type: Primary research

    Published on:

  49. Type D personality has been associated with a variety of emotional and social difficulties as well as with poor prognosis in patients with established coronary heart disease (CHD). We examined the psychometric...

    Authors: Christos Christodoulou, Athanasios Douzenis, Paula MC Mommersteeg, Loukianos Rallidis, Antonis Poulios, Vasiliki Efstathiou, Georgios Bouras, Christos Varounis, Panagiota Korkoliakou, John Palios, Dimitrios Th Kremastinos and Lefteris Lykouras

    Citation: Annals of General Psychiatry 2013 12:38

    Content type: Primary research

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  50. Maternal depression has a negative impact on both the mother and child's physical and mental health, as well as impairs parenting skills and pediatric health care utilization. The pediatricians' role in identi...

    Authors: Eirini Agapidaki, Kyriakos Souliotis, Stylianos Christogiorgos, lannis Zervas, Angeliki Leonardou, Gerasimos Kolaitis, George Giannakopoulos, Christina Dimitrakaki and Yannis Tountas

    Citation: Annals of General Psychiatry 2013 12:37

    Content type: Primary research

    Published on:

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  • ISSN: 1744-859X (electronic)

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Annals of General Psychiatry

ISSN: 1744-859X