Neuregulins are a family of signalling proteins that orchestrate a broad range of cellular responses. Four genes encoding Neuregulins 1–4 have been identified so far in vertebrates. Among them, Neuregulin 1 an...
Authors: Álvaro Díez, Clara Cieza-Borrella, Vanessa Suazo, Rogelio González-Sarmiento, Sergi Papiol and Vicente Molina
Although there is a wide variety of antidepressants with different mechanisms of action available, the efficacy of treatment is not satisfactory. Genetic factors are presumed to play a role in differences in m...
Authors: Dávid Kovacs, Xénia Gonda, Péter Petschner, Andrea Edes, Nóra Eszlari, György Bagdy and Gabriella Juhasz
The early contributions of childhood trauma (emotional, physical, sexual, and general) have been hypothesized to play a significant role in the development of anxiety disorders, such as posttraumatic stress di...
Authors: Melanie Bishop, David Rosenstein, Susanne Bakelaar and Soraya Seedat
Facial emotion perception (FEP) can affect social function. We previously reported that parts of five tested single-nucleotide polymorphisms (SNPs) in the MET and AKT1 genes may individually affect FEP perform...
Authors: Li-Yeh Chuang, Hsien-Yuan Lane, Yu-Da Lin, Ming-Teng Lin, Cheng-Hong Yang and Hsueh-Wei Chang
During the last few years, many countries in Europe suffered from a severe economic crisis which resulted in high unemployment rates. In this frame, the possible relationship between unemployment rate and suic...
Authors: Konstantinos N Fountoulakis, Xenia Gonda, Peter Dome, Pavlos N Theodorakis and Zoltan Rihmer
From the ancient times, there are three basic approaches for the interpretation of the different psychic phenomena: the organic, the psychological, and the sacred approach. The sacred approach forms the primor...
Authors: Georgios Tzeferakos and Athanasios Douzenis
Many patients with schizophrenia receive long-term treatment with antipsychotic medication. Switching of antipsychotic medication due to lack of efficacy, tolerability issues, and partial/non-adherence is comm...
Authors: Joseph Peuskens, Gabriel Rubio and Andreas Schreiner
In Japan, new legislation regarding forensic mental health, namely, the Act on Medical Care and Treatment for Persons Who Have Caused Serious Cases under the Condition of Insanity (Medical Treatment and Superv...
Authors: Akihiro Shiina, Masaomi Iyo, Akira Yoshizumi and Naotsugu Hirabayashi
Many studies have shown that the prevalence of smoking in schizophrenia is higher than in the general population. Biological, psychological and social factors influence smoking in patients with schizophrenia.
Authors: Hiranya Wijesundera, Raveen Hanwella and Varuni A de Silva
The objective of this research was to examine treatment patterns and health-care costs associated with second-step pharmacotherapy in patients with major depressive disorder (MDD) who initiated monotherapy wit...
Authors: Susan Ball, Peter Classi and Ellen B Dennehy
Internet addiction (IA) is considered as one of behavioral addictions. Although common neurobiological mechanisms have been suggested to underlie behavioral addiction and substance dependence, few studies have...
Authors: Jae Yeon Hwang, Jung-Seok Choi, Ah Reum Gwak, Dawn Jung, Sam-Wook Choi, Jaewon Lee, Jun-Young Lee, Hee Yeon Jung and Dai Jin Kim
It has been suggested that interpersonal sensitivity, a personality trait associated with depression and anxiety disorders, is linked with attachment insecurity. To confirm this link, we studied the correlatio...
Acute and transient psychotic disorder (ATPD) has been described as an acute psychosis with brief onset and polymorphous symptomatology (WHO, 1993). The study of ATPD is growing increasingly relevant as scient...
Courses such as Mental Health First Aid equip members of the public to perform appropriate helping behaviours towards people experiencing a mental illness or mental health crisis. However, studies investigatin...
Authors: Alyssia Rossetto, Anthony F Jorm and Nicola J Reavley
Early childhood education services create potentially optimal opportunities to identify and respond effectively to preschoolers' mental health problems. However, little is known about the knowledge, skills and...
Authors: George Giannakopoulos, Eirini Agapidaki, Christine Dimitrakaki, Despoina Oikonomidou, Dimitra Petanidou, Lia Tsermidou, Gerasimos Kolaitis, Yannis Tountas and Kalliroi Papadopoulou
Patients under antipsychotic treatment for schizophrenia commonly exhibit poor adherence to treatment, high rates of treatment discontinuation, and frequent treatment changes. The ETOS study aimed to identify ...
Authors: Andreas Roussidis, Christina Kalkavoura, Dimos Dimelis, Afroditi Theodorou, Ina Ioannidou, Eleytherios Mellos, Triantafyllia Mylonaki, Areti Spyropoulou and Andreas Yfantis
Patient satisfaction is an important outcome variable that is increasingly used in mental health service evaluation. There are no results available for patients with obsessive-compulsive disorder (OCD) yet.
Authors: Paraskevi Mavrogiorgou, Frauke Siebers, Georg Juckel and Thorsten Kienast
Patients with schizophrenia often experience comorbid obsessive-compulsive symptoms. Within these patients, a significant subgroup developed secondary obsessive-compulsive symptoms during treatment with clozap...
Authors: Gül Eryılmaz, Gökben Hızlı Sayar, Eylem Ozten, Işıl Gögcegöz Gül and Oğuz Karamustafalıoğlu
Type D personality has been associated with a variety of emotional and social difficulties as well as with poor prognosis in patients with established coronary heart disease (CHD). We examined the psychometric...
Authors: Christos Christodoulou, Athanasios Douzenis, Paula MC Mommersteeg, Loukianos Rallidis, Antonis Poulios, Vasiliki Efstathiou, Georgios Bouras, Christos Varounis, Panagiota Korkoliakou, John Palios, Dimitrios Th Kremastinos and Lefteris Lykouras
Maternal depression has a negative impact on both the mother and child's physical and mental health, as well as impairs parenting skills and pediatric health care utilization. The pediatricians' role in identi...
Authors: Eirini Agapidaki, Kyriakos Souliotis, Stylianos Christogiorgos, lannis Zervas, Angeliki Leonardou, Gerasimos Kolaitis, George Giannakopoulos, Christina Dimitrakaki and Yannis Tountas
Whether depression or cardiovascular disease would have a greater effect on worsening cognitive impairment in the burgeoning older elderly population is uncertain. Which disorder causes greater cognitive impai...
Authors: Yun-Hsuan Chang, Mu-En Liu, Chih-Chun Huang, Yan-Chiou Ku, Sheng-Yu Lee, Shiou-Lan Chen, Wen-Chien Liu and Ru-Band Lu
In South Korea, it has not been easy to negotiate studies that target drug users who are being punished by law, and accordingly, no study on suicidal ideation among substance users has been accomplished yet. I...
Authors: Min Kwon, Soo Yang, Kyongran Park and Dai-Jin Kim
Several studies have reported significantly higher stress levels, both short and long terms, among mothers giving preterm birth compared with mothers giving birth at term. Stress, however, is a psychological p...
Authors: Aud R Misund, Per Nerdrum, Stein Bråten, Are Hugo Pripp and Trond H Diseth
Adolescence represents one of the critical transitions in the life span and is characterized by a tremendous pace in growth and change that is second only to that of infancy. Both biological and psychological ...
Authors: Concetta De Pasquale, Maria Luisa Pistorio, Eleonora Tornatore, Domenico De Berardis and Michele Fornaro
Relapse in patients with schizophrenia has devastating repercussions, including worsening symptoms, impaired functioning, cognitive deterioration and reduced quality of life. This progressive decline exacerbat...
Authors: José M Olivares, Jan Sermon, Michiel Hemels and Andreas Schreiner
Several lines of evidence suggest that dysfunction of the dorsolateral prefrontal cortex (DLPFC) and orbitofrontal cortex (OFC) contributes to the pathophysiology of pervasive developmental disorders (PDD). Th...
Individuals with posttraumatic stress disorder (PTSD) are more likely to undertake harmful health behaviors like substance use. Less is known about the association of PTSD with healthful behaviors such as heal...
Authors: Kathryn M Godfrey, Laurie A Lindamer, Sheeva Mostoufi and Niloofar Afari
The 22q11.2 deletion syndrome is caused by a microdeletion of chromosome 22. One third of all patients with 22q11.2 deletion develop schizophrenia-like symptoms. In general, the prevalence of 22q11.2 deletion ...
The Subjective Well-Being Under Neuroleptic Treatment Scale short form (SWN-K) is a self-rating scale developed to measure mentally ill patients' well-being under the antipsychotic drug treatment. This paper r...
Authors: Liina Haring, René Mõttus, Peeter Jaanson, Raine Pilli, Kairi Mägi and Eduard Maron
Caring for individuals with schizophrenia can create distress for caregivers which can, in turn, have a harmful impact on patient progress. There could be a better understanding of the connections between care...
Authors: Shyhrete Rexhaj, Nataly Viens Python, Diane Morin, Charles Bonsack and Jérôme Favrod
During the last decade, a number of meta-analyses questioned the clinically relevant efficacy of antidepressants. Part of the debate concerned the method used in each of these meta-analyses as well as the qual...
Authors: Konstantinos N Fountoulakis, Areti Angeliki Veroniki, Melina Siamouli and Hans-Jürgen Möller
Anxiety is a major risk factor for problematic school absenteeism. However, most anxious students attend school. What differentiates anxious attenders from non-attenders?
Medically unexplained symptoms have been reported among both civilians and military personnel exposed to combat. A large number of military personnel deployed to the Gulf War in 1991 reported non-specific symp...
Authors: Varuni A de Silva, Nicholas ELW Jayasekera and Raveen Hanwella
Cushing’s syndrome can present with a spectrum of symptoms; however, it is less recognised that psychiatric symptoms can form part of the clinical presenting features. In the investigations for an organic caus...
Authors: Alice Tang, Anthony J O’Sullivan, Terry Diamond, Andrew Gerard and Peter Campbell
Increasing availability and use of long-acting injectable antipsychotics have generated a need to compare these formulations with their oral equivalents; however, a paucity of relevant data is available.
Authors: Michael Markowitz, Dong-Jing Fu, Bennett Levitan, Srihari Gopal, Ibrahim Turkoz and Larry Alphs
Annual suicide rates of Hungary were unexpectedly high in the previous century. In our narrative review, we try to depict, with presentation of the raw data, the main descriptive epidemiological features of th...
Authors: Zoltan Rihmer, Xenia Gonda, Balazs Kapitany and Peter Dome
It has been reported that oral health is poor in elderly populations and is associated with poor cognition and dementia. The objective of this study was to examine the association between tooth loss and cognit...
This observational study documented heart rate over the entire course of electrically induced seizures and aimed to evaluate the effects of stimulus electrode placement, patients' age, stimulus dose, and addit...
Little focus has been paid to the role of poor mental health and childhood abuse among young people with regard to human immunodeficiency virus (HIV) risk behaviour and HIV prevention in Africa. The aim of thi...
Authors: Karl Peltzer, Supa Pengpid and Issaka Tiembre
Considered as a moment of psychological vulnerability, adolescence is remarkably a risky period for the development of psychopathologies, when the choice of the correct therapeutic approach is crucial for achi...
Authors: Nádia NR Lima, Vânia B Nascimento, Jorge AC Peixoto, Marcial M Moreira, Modesto LR Neto, José C Almeida, Carlos AC Vasconcelos, Saulo A Teixeira, Jucier G Júnior, Francisco TC Junior, Diego DM Guimarães, Aline Q Brasil, Jesus S Cartaxo, Marco Akerman and Alberto OA Reis
Khat is a well-known natural stimulant from the Catha edulis plant and is widely used in certain Red Sea countries, including Yemen and the province of Jazan in Saudi Arabia. Jazan is located in the southwestern ...
Authors: Mohamed Salih Mahfouz, Rashad Mohammed Alsanosy and Abdelrahim Mutwakel Gaffar
Studies on mental health problems during childhood and youth development phases have reported that families of children diagnosed with a depressive disorder tend to be dysfunctional. These dysfunctions have be...
Authors: Lincoln I Khasakhala, David Musyimi Ndetei, Muthoni Mathai and Valerie Harder
The therapeutic alliance is related to better course and outcome of treatment in schizophrenia. This study explores predictors and characteristics of the therapeutic alliance in recent-onset schizophrenia spec...
Authors: Ragnhild Johansen, Valentina C Iversen, Ingrid Melle and Knut A Hestad
Suicide is a major cause of death among youths particularly with psychiatric, alcohol abuse and substance abuse disorders. There are relatively few studies on the relationship between psychiatric and substance...
Authors: Lincoln I Khasakhala, David M Ndetei and Muthoni Mathai
Repetitive transcranial magnetic stimulation (rTMS) can enhance the excitement of the brain through adjusting the biological activities of the cerebral cortex and has wide biological effects, making it one bas...
Authors: Eylem Ozten, Gokben Hizli Sayar and Oguz Karamustafalioglu
During the last decade, there was a debate concerning the true efficacy of antidepressants. Several papers were published in scientific journals, but many articles were also published in the lay press and the ...
Authors: Konstantinos N Fountoulakis, Cyril Hoschl, Siegfried Kasper, Juan Lopez-Ibor and Hans-Jürgen Möller
