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  1. Several lines of evidence suggest that dysfunction of the dorsolateral prefrontal cortex (DLPFC) and orbitofrontal cortex (OFC) contributes to the pathophysiology of pervasive developmental disorders (PDD). Th...

    Authors: Tetsuji Sawa, Masaki Kodaira, Arata Oiji, Daimei Sasayama, Yoshitaka Iwadare, Hirokage Ushijima, Masahide Usami, Kyota Watanabe and Kazuhiko Saito

    Citation: Annals of General Psychiatry 2013 12:31

    Content type: Primary research

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  2. Individuals with posttraumatic stress disorder (PTSD) are more likely to undertake harmful health behaviors like substance use. Less is known about the association of PTSD with healthful behaviors such as heal...

    Authors: Kathryn M Godfrey, Laurie A Lindamer, Sheeva Mostoufi and Niloofar Afari

    Citation: Annals of General Psychiatry 2013 12:30

    Content type: Primary research

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  3. The 22q11.2 deletion syndrome is caused by a microdeletion of chromosome 22. One third of all patients with 22q11.2 deletion develop schizophrenia-like symptoms. In general, the prevalence of 22q11.2 deletion ...

    Authors: Kazutaka Ohi, Ryota Hashimoto, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Noriko Nakatani, Kouzin Kamino and Masatoshi Takeda

    Citation: Annals of General Psychiatry 2013 12:29

    Content type: Case report

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  4. The Subjective Well-Being Under Neuroleptic Treatment Scale short form (SWN-K) is a self-rating scale developed to measure mentally ill patients' well-being under the antipsychotic drug treatment. This paper r...

    Authors: Liina Haring, René Mõttus, Peeter Jaanson, Raine Pilli, Kairi Mägi and Eduard Maron

    Citation: Annals of General Psychiatry 2013 12:28

    Content type: Primary research

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  5. Caring for individuals with schizophrenia can create distress for caregivers which can, in turn, have a harmful impact on patient progress. There could be a better understanding of the connections between care...

    Authors: Shyhrete Rexhaj, Nataly Viens Python, Diane Morin, Charles Bonsack and Jérôme Favrod

    Citation: Annals of General Psychiatry 2013 12:27

    Content type: Primary research

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  6. During the last decade, a number of meta-analyses questioned the clinically relevant efficacy of antidepressants. Part of the debate concerned the method used in each of these meta-analyses as well as the qual...

    Authors: Konstantinos N Fountoulakis, Areti Angeliki Veroniki, Melina Siamouli and Hans-Jürgen Möller

    Citation: Annals of General Psychiatry 2013 12:26

    Content type: Review

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  9. Cushing’s syndrome can present with a spectrum of symptoms; however, it is less recognised that psychiatric symptoms can form part of the clinical presenting features. In the investigations for an organic caus...

    Authors: Alice Tang, Anthony J O’Sullivan, Terry Diamond, Andrew Gerard and Peter Campbell

    Citation: Annals of General Psychiatry 2013 12:23

    Content type: Case report

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  10. Increasing availability and use of long-acting injectable antipsychotics have generated a need to compare these formulations with their oral equivalents; however, a paucity of relevant data is available.

    Authors: Michael Markowitz, Dong-Jing Fu, Bennett Levitan, Srihari Gopal, Ibrahim Turkoz and Larry Alphs

    Citation: Annals of General Psychiatry 2013 12:22

    Content type: Primary research

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  11. Annual suicide rates of Hungary were unexpectedly high in the previous century. In our narrative review, we try to depict, with presentation of the raw data, the main descriptive epidemiological features of th...

    Authors: Zoltan Rihmer, Xenia Gonda, Balazs Kapitany and Peter Dome

    Citation: Annals of General Psychiatry 2013 12:21

    Content type: Review

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  12. It has been reported that oral health is poor in elderly populations and is associated with poor cognition and dementia. The objective of this study was to examine the association between tooth loss and cognit...

    Authors: Yuki Saito, Norio Sugawara, Norio Yasui-Furukori, Ippei Takahashi, Shigeyuki Nakaji and Hiroto Kimura

    Citation: Annals of General Psychiatry 2013 12:20

    Content type: Primary research

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  13. This observational study documented heart rate over the entire course of electrically induced seizures and aimed to evaluate the effects of stimulus electrode placement, patients' age, stimulus dose, and addit...

    Authors: Josef Nagler

    Citation: Annals of General Psychiatry 2013 12:19

    Content type: Primary research

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  14. Little focus has been paid to the role of poor mental health and childhood abuse among young people with regard to human immunodeficiency virus (HIV) risk behaviour and HIV prevention in Africa. The aim of thi...

    Authors: Karl Peltzer, Supa Pengpid and Issaka Tiembre

    Citation: Annals of General Psychiatry 2013 12:18

    Content type: Primary research

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  15. Considered as a moment of psychological vulnerability, adolescence is remarkably a risky period for the development of psychopathologies, when the choice of the correct therapeutic approach is crucial for achi...

    Authors: Nádia NR Lima, Vânia B Nascimento, Jorge AC Peixoto, Marcial M Moreira, Modesto LR Neto, José C Almeida, Carlos AC Vasconcelos, Saulo A Teixeira, Jucier G Júnior, Francisco TC Junior, Diego DM Guimarães, Aline Q Brasil, Jesus S Cartaxo, Marco Akerman and Alberto OA Reis

    Citation: Annals of General Psychiatry 2013 12:17

    Content type: Review

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  16. Khat is a well-known natural stimulant from the Catha edulis plant and is widely used in certain Red Sea countries, including Yemen and the province of Jazan in Saudi Arabia. Jazan is located in the southwestern ...

    Authors: Mohamed Salih Mahfouz, Rashad Mohammed Alsanosy and Abdelrahim Mutwakel Gaffar

    Citation: Annals of General Psychiatry 2013 12:16

    Content type: Primary research

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  17. Studies on mental health problems during childhood and youth development phases have reported that families of children diagnosed with a depressive disorder tend to be dysfunctional. These dysfunctions have be...

    Authors: Lincoln I Khasakhala, David Musyimi Ndetei, Muthoni Mathai and Valerie Harder

    Citation: Annals of General Psychiatry 2013 12:15

    Content type: Primary research

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  18. The therapeutic alliance is related to better course and outcome of treatment in schizophrenia. This study explores predictors and characteristics of the therapeutic alliance in recent-onset schizophrenia spec...

    Authors: Ragnhild Johansen, Valentina C Iversen, Ingrid Melle and Knut A Hestad

    Citation: Annals of General Psychiatry 2013 12:14

    Content type: Primary research

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  19. Suicide is a major cause of death among youths particularly with psychiatric, alcohol abuse and substance abuse disorders. There are relatively few studies on the relationship between psychiatric and substance...

    Authors: Lincoln I Khasakhala, David M Ndetei and Muthoni Mathai

    Citation: Annals of General Psychiatry 2013 12:13

    Content type: Primary research

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  20. Repetitive transcranial magnetic stimulation (rTMS) can enhance the excitement of the brain through adjusting the biological activities of the cerebral cortex and has wide biological effects, making it one bas...

    Authors: Eylem Ozten, Gokben Hizli Sayar and Oguz Karamustafalioglu

    Citation: Annals of General Psychiatry 2013 12:12

    Content type: Case report

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  21. During the last decade, there was a debate concerning the true efficacy of antidepressants. Several papers were published in scientific journals, but many articles were also published in the lay press and the ...

    Authors: Konstantinos N Fountoulakis, Cyril Hoschl, Siegfried Kasper, Juan Lopez-Ibor and Hans-Jürgen Möller

    Citation: Annals of General Psychiatry 2013 12:11

    Content type: Commentary

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  22. Patients’ informed consent prior to treatment initiation is an essential component of contemporary clinical practice, but sometimes, patients lack decision-making capacity for treatment. Such capacity can be r...

    Authors: Nikolaos Bilanakis, Aikaterini Vratsista, Georgios Kalampokis, Georgios Papamichael and Vaios Peritogiannis

    Citation: Annals of General Psychiatry 2013 12:10

    Content type: Primary research

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  25. It has been estimated that as many as two thirds of patients with schizophrenia are unable to perform basic personal and social roles or activities. Occupational functioning and social functioning, as well as ...

    Authors: Philip Gorwood, Tom Burns, Georg Juckel, Alessandro Rossi, Luis San, Ludger Hargarter and Andreas Schreiner

    Citation: Annals of General Psychiatry 2013 12:8

    Content type: Primary research

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  26. This case report details the therapeutic effects of tandospirone on two patients with anorexia nervosa, one with the restricting subtype (ANR), and another with the binge-eating/purging subtype (ANBP). A 22-ye...

    Authors: Kyoji Okita, Akihiro Shiina, Michiko Nakazato and Masaomi Iyo

    Citation: Annals of General Psychiatry 2013 12:7

    Content type: Case report

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  27. One of the most intriguing frontiers of current neuroscientific research is represented by the investigation of the possible neural substrates of morality. The assumption is that in humans an innate moral sens...

    Authors: Donatella Marazziti, Stefano Baroni, Paola Landi, Diana Ceresoli and Liliana Dell’Osso

    Citation: Annals of General Psychiatry 2013 12:6

    Content type: Review

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  28. Quality of life (QoL) is increasingly recognized as a critical outcome parameter in mental health studies. The aim of this study was to investigate different domains of the QoL in persons with obsessive-compul...

    Authors: Elisabeth Hertenstein, Nicola Thiel, Nirmal Herbst, Tobias Freyer, Christoph Nissen, Anne Katrin Külz and Ulrich Voderholzer

    Citation: Annals of General Psychiatry 2013 12:4

    Content type: Primary research

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  29. The changes in the organization of mental health care services have made the role of the family even more important in caring for patients with mental disorders. Caring may have serious consequences for family...

    Authors: Vasiliki Sapouna, Vasilis Dafermos, Marios Chatziarsenis, Victoria Vivilaki, Panos Bitsios, Aart H Schene and Christos Lionis

    Citation: Annals of General Psychiatry 2013 12:3

    Content type: Primary research

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  30. The clinical global impression of severity (CGI-S) scale is a frequently used rating instrument for the assessment of global severity of illness in Central Nervous System (CNS) trials. Although scoring guideli...

    Authors: Steven D Targum, Celine Houser, Joanne Northcutt, Jessica A Little, Andrew J Cutler and David P Walling

    Citation: Annals of General Psychiatry 2013 12:2

    Content type: Primary research

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  31. While indicated for schizophrenia and acute mania, ziprasidone’s evidence base and use in clinical practice extends beyond these regulatory approvals. We, an invited panel of experts led by a working group of ...

    Authors: David M Gardner, Andrea L Murphy, Stan Kutcher, Serge Beaulieu, Carlo Carandang, Alain Labelle, Pierre Lalonde, Ashok Malla, Heather Milliken, Claire O’Donovan, Ayal Schaffer, Jorge Soni, Valerie H Taylor and Richard Williams

    Citation: Annals of General Psychiatry 2013 12:1

    Content type: Review

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  32. The objective of this study was to quantify the direct medical resources used and the corresponding burden of disease in the treatment of patients with schizophrenia. Because low-frequency administration (LFA)...

    Authors: Nicolas M Furiak, James C Gahn, Robert W Klein, Stephen B Camper and Kent H Summers

    Citation: Annals of General Psychiatry 2012 11:29

    Content type: Primary research

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  33. This paper applies the Biobehavioral Family Model (BBFM) of stress- related illness to the study and treatment of an adolescent with intractable asthma. The model is described, along with supportive research f...

    Authors: Maria Theodoratou-Bekou, Ourania Andreopoulou, Panoraia Andriopoulou and Beatrice Wood

    Citation: Annals of General Psychiatry 2012 11:28

    Content type: Case report

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  34. The topic of sexual obsessions as a psychiatric symptom has not been well investigated. The aim of this study was twofold: 1) to explore the presence of sexual obsessions in patients with mood disorders (n=156), ...

    Authors: Liliana Dell’Osso, Giulia Casu, Marina Carlini, Ciro Conversano, Paola Gremigni and Claudia Carmassi

    Citation: Annals of General Psychiatry 2012 11:27

    Content type: Primary research

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  36. Several lines of evidence implicate orbitofrontal cortex dysfunction in the pathophysiology of obsessive-compulsive disorder (OCD). The purpose of this study was to investigate neuropsychological dysfunction o...

    Authors: Masaki Kodaira, Yoshitaka Iwadare, Hirokage Ushijima, Arata Oiji, Motoichiro Kato, Nobuhiro Sugiyama, Daimei Sasayama, Masahide Usami, Kyota Watanabe and Kazuhiko Saito

    Citation: Annals of General Psychiatry 2012 11:25

    Content type: Primary research

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  37. Studies of the associations between diet and depression have primarily focused on single nutrients or foods. Recently, dietary patterns representing a combination of foods have attracted more interest than ind...

    Authors: Norio Sugawara, Norio Yasui-Furukori, Shoko Tsuchimine, Ayako Kaneda, Koji Tsuruga, Kaori Iwane, Noriyuki Okubo, Ippei Takahashi and Sunao Kaneko

    Citation: Annals of General Psychiatry 2012 11:24

    Content type: Primary research

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  38. Studies on the ‘self-medication hypothesis’ have focused on substance abuse as an attempt to alleviate emotional suffering.

    Authors: Icro Maremmani, Angelo Giovanni Icro Maremmani, Fabio Rugani, Luca Rovai, Matteo Pacini, Silvia Bacciardi, Joseph Deltito, Liliana Dell’Osso and Hagop S Akiskal

    Citation: Annals of General Psychiatry 2012 11:23

    Content type: Primary research

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  39. The aim of the study was to determine the most common treatment strategies and their costs for patients with an inadequate response to first-line antidepressant treatment (AD) in primary care.

    Authors: Antoni Sicras-Mainar, Jorge Maurino, Luis Cordero, Milagrosa Blanca-Tamayo and Ruth Navarro-Artieda

    Citation: Annals of General Psychiatry 2012 11:22

    Content type: Primary research

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  40. Studies performed to assess the relevance of duration of untreated psychosis (DUP) as a predictor of long-term outcome (i.e. follow-ups of ten years or more) are somewhat limited. The aim of this study was to ...

    Authors: Diego Primavera, Chiara Bandecchi, Tiziana Lepori, Lucia Sanna, Eraldo Nicotra and Bernardo Carpiniello

    Citation: Annals of General Psychiatry 2012 11:21

    Content type: Primary research

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  41. A limited number of studies have assessed the pathways to care of patients experiencing psychosis for the first time. Helpline/clinic programs may offer patients who are still functional but have potential for...

    Authors: Amresh K Shrivastava, Megan E Johnston, Larry Stitt, Meghana Thakar, Gopa Sakel, Sunita Iyer, Nilesh Shah and Yves Bureau

    Citation: Annals of General Psychiatry 2012 11:20

    Content type: Primary research

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  42. Dopamine dysregulation syndrome (DDS) consists of a series of complications such as compulsive use of dopaminergic medications, aggressive or hypomanic behaviors during excessive use, and withdrawal states cha...

    Authors: Jin Mizushima, Keisuke Takahata, Noriko Kawashima and Motoichiro Kato

    Citation: Annals of General Psychiatry 2012 11:19

    Content type: Case report

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  43. Patients having chronic schizophrenia with frequent relapses and hospitalizations represent a great challenge, both clinically and financially. Risperidone long-acting injection (RIS-LAI) has been the main LAI...

    Authors: Thomas R Einarson, Maria Geitona, Alexandros Chaidemenos, Vasiliki Karpouza, Theodoros Mougiakos, Periklis Paterakis, Dimitrios Ploumpidis, Dionyssios Potamitis-Komis, Roman Zilbershtein, Colin Vicente, Charles Piwko, Panagiotis Kakkavas, Konstantina Paparouni, Rasmus C D Jensen and Michiel E H Hemels

    Citation: Annals of General Psychiatry 2012 11:18

    Content type: Primary research

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  44. Experience of common health symptoms without a clear physical or psychological cause, such as headache or dizziness, is often reported in adolescence. The present study attempted to investigate associations of...

    Authors: Dimitra Petanidou, George Giannakopoulos, Chara Tzavara, Christine Dimitrakaki, Ulricke Ravens-Sieberer, Gerasimos Kolaitis and Yannis Tountas

    Citation: Annals of General Psychiatry 2012 11:17

    Content type: Primary research

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  46. The primary objective of this study was to evaluate long-term (24-week) safety of eszopiclone in elderly and nonelderly Japanese patients with chronic insomnia. The secondary objectives were to evaluate short-...

    Authors: Naohisa Uchimura, Atsushi Kamijo and Takao Takase

    Citation: Annals of General Psychiatry 2012 11:15

    Content type: Primary research

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  47. The assessment of functioning and disability is an important part of the clinical evaluation, since it measures disease burden and reflects the effectiveness of therapeutic planning and interventions. The aim ...

    Authors: Konstantinos N Fountoulakis, Eirini Lekka, Evangelia Kouidi, Ioanna Chouvarda, Asterios Deligiannis and Nickolaos Maglaveras

    Citation: Annals of General Psychiatry 2012 11:14

    Content type: Primary research

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  48. About 25% of schizophrenia patients with auditory hallucinations are refractory to pharmacotherapy and electroconvulsive therapy. We conducted a deep transcranial magnetic stimulation (TMS) pilot study in orde...

    Authors: Oded Rosenberg, Roman Gersner, Limor Dinur Klein, Moshe Kotler, Abraham Zangen and Pinhas Dannon

    Citation: Annals of General Psychiatry 2012 11:13

    Content type: Primary research

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  49. This case is of 54-year-old female with catatonic schizophrenia, characterized by treatment resistance to the pharmacotherapy with olanzapine, risperidone, flunitrazepam, and ECT. Olanzapine and risperidone an...

    Authors: Tsuyoshi Sasaki, Tasuku Hashimoto, Tomihisa Niitsu, Nobuhisa Kanahara and Masaomi Iyo

    Citation: Annals of General Psychiatry 2012 11:12

    Content type: Case report

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  50. Recently, a relationship between obesity and schizophrenia has been reported. Although fat- mass and fat free mass have been shown to be more predictive of health risk than body mass index, there are limited f...

    Authors: Norio Sugawara, Norio Yasui-Furukori, Shoko Tsuchimine, Akira Fujii, Yasushi Sato, Manabu Saito, Masashi Matsuzaka, Ippei Takahashi and Sunao Kaneko

    Citation: Annals of General Psychiatry 2012 11:11

    Content type: Primary research

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  • ISSN: 1744-859X (electronic)

Annals of General Psychiatry

ISSN: 1744-859X