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  1. The aim of the study was to determine the most common treatment strategies and their costs for patients with an inadequate response to first-line antidepressant treatment (AD) in primary care.

    Authors: Antoni Sicras-Mainar, Jorge Maurino, Luis Cordero, Milagrosa Blanca-Tamayo and Ruth Navarro-Artieda

    Citation: Annals of General Psychiatry 2012 11:22

    Content type: Primary research

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  2. Studies performed to assess the relevance of duration of untreated psychosis (DUP) as a predictor of long-term outcome (i.e. follow-ups of ten years or more) are somewhat limited. The aim of this study was to ...

    Authors: Diego Primavera, Chiara Bandecchi, Tiziana Lepori, Lucia Sanna, Eraldo Nicotra and Bernardo Carpiniello

    Citation: Annals of General Psychiatry 2012 11:21

    Content type: Primary research

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  3. A limited number of studies have assessed the pathways to care of patients experiencing psychosis for the first time. Helpline/clinic programs may offer patients who are still functional but have potential for...

    Authors: Amresh K Shrivastava, Megan E Johnston, Larry Stitt, Meghana Thakar, Gopa Sakel, Sunita Iyer, Nilesh Shah and Yves Bureau

    Citation: Annals of General Psychiatry 2012 11:20

    Content type: Primary research

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  4. Dopamine dysregulation syndrome (DDS) consists of a series of complications such as compulsive use of dopaminergic medications, aggressive or hypomanic behaviors during excessive use, and withdrawal states cha...

    Authors: Jin Mizushima, Keisuke Takahata, Noriko Kawashima and Motoichiro Kato

    Citation: Annals of General Psychiatry 2012 11:19

    Content type: Case report

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  5. Patients having chronic schizophrenia with frequent relapses and hospitalizations represent a great challenge, both clinically and financially. Risperidone long-acting injection (RIS-LAI) has been the main LAI...

    Authors: Thomas R Einarson, Maria Geitona, Alexandros Chaidemenos, Vasiliki Karpouza, Theodoros Mougiakos, Periklis Paterakis, Dimitrios Ploumpidis, Dionyssios Potamitis-Komis, Roman Zilbershtein, Colin Vicente, Charles Piwko, Panagiotis Kakkavas, Konstantina Paparouni, Rasmus C D Jensen and Michiel E H Hemels

    Citation: Annals of General Psychiatry 2012 11:18

    Content type: Primary research

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  6. Experience of common health symptoms without a clear physical or psychological cause, such as headache or dizziness, is often reported in adolescence. The present study attempted to investigate associations of...

    Authors: Dimitra Petanidou, George Giannakopoulos, Chara Tzavara, Christine Dimitrakaki, Ulricke Ravens-Sieberer, Gerasimos Kolaitis and Yannis Tountas

    Citation: Annals of General Psychiatry 2012 11:17

    Content type: Primary research

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  7. The primary objective of this study was to evaluate long-term (24-week) safety of eszopiclone in elderly and nonelderly Japanese patients with chronic insomnia. The secondary objectives were to evaluate short-...

    Authors: Naohisa Uchimura, Atsushi Kamijo and Takao Takase

    Citation: Annals of General Psychiatry 2012 11:15

    Content type: Primary research

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  8. The assessment of functioning and disability is an important part of the clinical evaluation, since it measures disease burden and reflects the effectiveness of therapeutic planning and interventions. The aim ...

    Authors: Konstantinos N Fountoulakis, Eirini Lekka, Evangelia Kouidi, Ioanna Chouvarda, Asterios Deligiannis and Nickolaos Maglaveras

    Citation: Annals of General Psychiatry 2012 11:14

    Content type: Primary research

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  9. About 25% of schizophrenia patients with auditory hallucinations are refractory to pharmacotherapy and electroconvulsive therapy. We conducted a deep transcranial magnetic stimulation (TMS) pilot study in orde...

    Authors: Oded Rosenberg, Roman Gersner, Limor Dinur Klein, Moshe Kotler, Abraham Zangen and Pinhas Dannon

    Citation: Annals of General Psychiatry 2012 11:13

    Content type: Primary research

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  10. This case is of 54-year-old female with catatonic schizophrenia, characterized by treatment resistance to the pharmacotherapy with olanzapine, risperidone, flunitrazepam, and ECT. Olanzapine and risperidone an...

    Authors: Tsuyoshi Sasaki, Tasuku Hashimoto, Tomihisa Niitsu, Nobuhisa Kanahara and Masaomi Iyo

    Citation: Annals of General Psychiatry 2012 11:12

    Content type: Case report

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  11. Recently, a relationship between obesity and schizophrenia has been reported. Although fat- mass and fat free mass have been shown to be more predictive of health risk than body mass index, there are limited f...

    Authors: Norio Sugawara, Norio Yasui-Furukori, Shoko Tsuchimine, Akira Fujii, Yasushi Sato, Manabu Saito, Masashi Matsuzaka, Ippei Takahashi and Sunao Kaneko

    Citation: Annals of General Psychiatry 2012 11:11

    Content type: Primary research

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  12. Patients who self-poison have high repetition and high mortality rates. Therefore, appropriate follow-up is important. The aims of the present work were to study treatment received, satisfaction with health ca...

    Authors: Tine K Grimholt, Mari A Bjornaas, Dag Jacobsen, Gudrun Dieserud and Oivind Ekeberg

    Citation: Annals of General Psychiatry 2012 11:10

    Content type: Primary research

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  13. An imbalance in the production of proinflammatory and anti-inflammatory cytokines may play a role in the pathophysiology of perimenopausal depression. The aim of this study was to examine serum levels of the p...

    Authors: Sokratis E Karaoulanis, Alexandros Daponte, Katerina A Rizouli, Andreas A Rizoulis, Georgios A Lialios, Catherine T Theodoridou, Christos Christakopoulos and Nikiforos V Angelopoulos

    Citation: Annals of General Psychiatry 2012 11:9

    Content type: Primary research

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  14. Despite the achievements of previous research, caregiving assessments in severe mental illness should be crossculturally validated in order to define risk groups or to evaluate family work. This study reports ...

    Authors: Manuel Gonçalves-Pereira, Bob van Wijngaarden, Miguel Xavier, Ana L Papoila, José M Caldas-de-Almeida and Aart H Schene

    Citation: Annals of General Psychiatry 2012 11:8

    Content type: Primary research

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  15. Few studies have analyzed predictors of length of stay (LOS) in patients admitted due to acute bipolar manic episodes. The purpose of the present study was to estimate LOS and to determine the potential sociod...

    Authors: Manuel Martin-Carrasco, Ana Gonzalez-Pinto, Jaime L Galan, Javier Ballesteros, Jorge Maurino and Eduard Vieta

    Citation: Annals of General Psychiatry 2012 11:7

    Content type: Primary research

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  16. Many effective treatments for nicotine addiction inhibit noradrenaline reuptake. Three recent studies have suggested that another noradrenaline reuptake inhibitor, atomoxetine, may reduce smoking behaviors.

    Authors: Peter H Silverstone and Rana Dadashova

    Citation: Annals of General Psychiatry 2012 11:6

    Content type: Primary research

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  17. There have been a limited number of studies comparing bone mass between patients with schizophrenia and the general population. The aim of this study was to compare the bone mass of schizophrenia patients with...

    Authors: Norio Sugawara, Norio Yasui-Furukori, Takashi Umeda, Shoko Tsuchimine, Akira Fujii, Yasushi Sato, Manabu Saito, Hanako Furukori, Kazuma Danjo, Masashi Matsuzaka, Ippei Takahashi and Sunao Kaneko

    Citation: Annals of General Psychiatry 2012 11:5

    Content type: Primary research

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  18. The objective of this study was to assess sentinel event analysis and relative factors in different mental healthcare settings. In addition, the occurrence of sentinel events in different hospital settings was...

    Authors: Yi-Lung Chen, Dong-Sheng Tzeng, Ting-Sheng Cheng and Chien-Hung Lin

    Citation: Annals of General Psychiatry 2012 11:4

    Content type: Primary research

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  19. The KIDSCREEN-52 is a worldwide instrument for measuring health-related quality of life (HRQoL) in children and adolescents. The aim of this study is to assess reliability and validity of the Greek version of ...

    Authors: Chara Tzavara, Anastasia Tzonou, Ioannis Zervas, Ulricke Ravens-Sieberer, Christine Dimitrakaki and Yannis Tountas

    Citation: Annals of General Psychiatry 2012 11:3

    Content type: Primary research

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  20. We previously reported a case in which steroid-induced psychosis was eliminated with risperidone treatment in a patient with polyarteritis nodosa (PN). In the present report, we longitudinally tracked the seru...

    Authors: Reiji Yoshimura, Kosuke Saito, Tadanori Terada, Naoki Yunoue, Wakako Umene-Nakano, Shintaro Hirata, Kazuyoshi Saitoh, Yoshiya Tanaka and Jun Nakamura

    Citation: Annals of General Psychiatry 2012 11:2

    Content type: Case report

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  21. A standardized definition of remission criteria in schizophrenia was proposed by the International group of NC Andreasen in 2005 (low symptom threshold for the eight core Positive and Negative Syndrome Scale (...

    Authors: Sergey N Mosolov, Andrey V Potapov and Uriy V Ushakov

    Citation: Annals of General Psychiatry 2012 11:1

    Content type: Primary research

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  22. Although the promotion of mental health (MHP) through education and training is widely accepted, there is scarce evidence for its effectiveness in the literature from outcome studies worldwide. The present stu...

    Authors: Vlassis D Tomaras, Maria Ginieri-Coccossis, Maria Vassiliadou, Melpomeni Malliori, Spyros Ferentinos, Constantin R Soldatos and Andre Tylee

    Citation: Annals of General Psychiatry 2011 10:33

    Content type: Primary research

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  23. Several studies have reported high prevalence of anxiety and depression in chronic obstructive pulmonary disease (COPD) outpatients. Moreover, these patients share psychological or psychopathological character...

    Authors: Athanasios Tselebis, Dionisios Bratis, Epaminondas Kosmas, Maria Harikiopoulou, Elpida Theodorakopoulou, Silvia Dumitru, Georgios Moussas, Athanasios Karkanias, Ioannis Ilias, Nikolaos Siafakas, Alexandros Vgontzas and Nikolaos Tzanakis

    Citation: Annals of General Psychiatry 2011 10:32

    Content type: Primary research

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  24. It seems that the core neural regions and cognitive processes implicated in obsessive-compulsive disorder (OCD) pathophysiology may overlap with those involved in humor appreciation. However, to date, there ha...

    Authors: Vasilis P Bozikas, Mary H Kosmidis, Maria Giannakou, Aravela Adamopoulou, Xenia Gonda, Kostas Fokas and George Garyfallos

    Citation: Annals of General Psychiatry 2011 10:31

    Content type: Primary research

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  25. Around 9% to 20% of bereaved individuals experience symptoms of complicated grief (CG) that are associated with significant distress and impairment. A major issue is whether CG represents a distinctive nosogra...

    Authors: Liliana Dell'Osso, Claudia Carmassi, Martina Corsi, Irene Pergentini, Chiara Socci, Angelo GI Maremmani and Giulio Perugi

    Citation: Annals of General Psychiatry 2011 10:29

    Content type: Primary research

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  26. Psychological distress in healthcare workers may vary across different specialties. The purpose of this study was to investigate the differences in the rate of anxiety and depression between medical and mental...

    Authors: Ioanna V Papathanasiou, Dimitrios Damigos and Venetsanos Mavreas

    Citation: Annals of General Psychiatry 2011 10:28

    Content type: Primary research

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  27. Hearing impairment is a prevalent and chronic condition in older people. This study investigated the relationship between cognitive function and hearing impairment in a Japanese population.

    Authors: Norio Sugawara, Akira Sasaki, Norio Yasui-Furukori, Seiji Kakehata, Takashi Umeda, Atsushi Namba, Shigeyuki Nakaji, Hideichi Shinkawa and Sunao Kaneko

    Citation: Annals of General Psychiatry 2011 10:27

    Content type: Primary research

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  28. There is emerging evidence that antidepressants may be effective in preventing patients with non-specific and psychotic-like prodromal symptoms, defined as patients at ultra-high risk (UHR) of psychotic disord...

    Authors: Shigenori Tadokoro, Nobuhisa Kanahara, Shuichi Kikuchi, Kenji Hashimoto and Masaomi Iyo

    Citation: Annals of General Psychiatry 2011 10:26

    Content type: Case report

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  29. Increased prescription of antidepressants has been consistently associated with a decrease in suicide rates in several countries. The aim of this study is to explore antidepressant consumption, suicide rates a...

    Authors: Giuseppe Guaiana, Margherita Andretta, Eric Griez, Bruno Biancosino and Luigi Grassi

    Citation: Annals of General Psychiatry 2011 10:24

    Content type: Primary research

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  30. Despite multiple antidepressant options, major depressive disorder (MDD) still faces high non-response rates, eventually requiring anticonvulsant augmentation strategies too. The aim of this study was to explo...

    Authors: Michele Fornaro, Matteo Martino, Bruna Dalmasso, Salvatore Colicchio, Marzia Benvenuti, Giulio Rocchi, Andrea Escelsior and Giulio Perugi

    Citation: Annals of General Psychiatry 2011 10:23

    Content type: Primary research

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  31. Awareness of the importance of maintaining physical health for patients with severe mental illnesses has recently been on the increase. Although there are several elements contributing to poor physical health ...

    Authors: Fernando Chacón, Fernando Mora, Alicia Gervás-Ríos and Inmaculada Gilaberte

    Citation: Annals of General Psychiatry 2011 10:22

    Content type: Review

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  32. Lifestyle factors, such as an unbalanced diet and lack of physical activity, may affect the prevalence of metabolic syndrome (MetS) in schizophrenic patients. The aim of this study was to compare the MetS prev...

    Authors: Norio Sugawara, Norio Yasui-Furukori, Yasushi Sato, Ikuko Kishida, Hakuei Yamashita, Manabu Saito, Hanako Furukori, Taku Nakagami, Mitsunori Hatakeyama and Sunao Kaneko

    Citation: Annals of General Psychiatry 2011 10:21

    Content type: Primary research

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  33. Over 290,000 patients are undergoing hemodialysis (HD) in Japan. With old age, the odds of undergoing HD treatment sharply increase, as does the prevalence of cognitive impairment. The aim of the present work ...

    Authors: Gen Odagiri, Norio Sugawara, Atsuhiro Kikuchi, Ippei Takahashi, Takashi Umeda, Hisao Saitoh, Norio Yasui-Furukori and Sunao Kaneko

    Citation: Annals of General Psychiatry 2011 10:20

    Content type: Primary research

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  34. Although the 'copy of cube test', a version of which is included in the Short Test of Mental Status (STMS), has existed for years, little has been done to standardize it in detail. The aim of the current study...

    Authors: Konstantinos N Fountoulakis, Melina Siamouli, Stamatia Magiria, Panagiotis T Panagiotidis, Sotiris Kantartzis, Vassiliki A Terzoglou and Timucin Oral

    Citation: Annals of General Psychiatry 2011 10:19

    Content type: Primary research

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  35. Schizophrenia is among the most disabling of mental illnesses and frequently causes impaired functioning. We explore issues of definition and terminology, and the relationship between social functioning, cogni...

    Authors: Sofia Brissos, Andrew Molodynski, Vasco Videira Dias and Maria Luísa Figueira

    Citation: Annals of General Psychiatry 2011 10:18

    Content type: Review

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  36. The idea that the impact of opioid agonist treatment is influenced by the psychopathological profile of heroin addicts has not yet been investigated, and is based on the concept of a specific therapeutic actio...

    Authors: Angelo Giovanni Icro Maremmani, Luca Rovai, Pier Paolo Pani, Matteo Pacini, Francesco Lamanna, Fabio Rugani, Elisa Schiavi, Liliana Dell'Osso and Icro Maremmani

    Citation: Annals of General Psychiatry 2011 10:17

    Content type: Primary research

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  37. Anorexia nervosa carries the highest mortality rate of any psychiatric disorder. Even the most critically ill anorexic patients may present with normal 'standard' laboratory values, underscoring the need for a...

    Authors: Michael A Flierl, Jennifer L Gaudiani, Allison L Sabel, Carlin S Long, Philip F Stahel and Philip S Mehler

    Citation: Annals of General Psychiatry 2011 10:16

    Content type: Primary research

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  38. Since 1958 many, but not all studies have demonstrated that paternal age is a risk factor for schizophrenia. There may be many different explanations for differences between studies, including study design, sa...

    Authors: Morteza Naserbakht, Hamid-Reza Ahmadkhaniha, Bahareh Mokri and Cassandra L Smith

    Citation: Annals of General Psychiatry 2011 10:15

    Content type: Primary research

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  39. The 'double-diamond copy' task is a simple paper and pencil test part of the Bender-Gestalt Test and the Mini Mental State Examination (MMSE). Although it is a widely used test, its method of scoring is crude ...

    Authors: Konstantinos N Fountoulakis, Melina Siamouli, Panagiotis T Panagiotidis, Stamatia Magiria, Sotiris Kantartzis, Vassiliki A Terzoglou and Timucin Oral

    Citation: Annals of General Psychiatry 2011 10:13

    Content type: Primary research

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  40. This post hoc analysis (trial registration: ClinicalTrials.gov NCT00590577) assessed onset of efficacy and tolerability of acute treatment with once-monthly paliperidone palmitate (PP), a long-acting atypical ...

    Authors: Larry Alphs, Cynthia A Bossie, Jennifer K Sliwa, Yi-Wen Ma and Norris Turner

    Citation: Annals of General Psychiatry 2011 10:12

    Content type: Primary research

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  41. In Japan, hospitalization for the assessment of mentally disordered offenders under the Act on Medical Care and Treatment for the Persons Who Had Caused Serious Cases under the Condition of Insanity (the Medic...

    Authors: Akihiro Shiina, Mihisa Fujisaki, Takako Nagata, Yasunori Oda, Masatoshi Suzuki, Masahiro Yoshizawa, Masaomi Iyo and Yoshito Igarashi

    Citation: Annals of General Psychiatry 2011 10:11

    Content type: Primary research

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  42. Because wide variations in mental health care utilization exist throughout the world, determining long-term effectiveness of psychotropic medications in a real-world setting would be beneficial to physicians a...

    Authors: Tim Lambert, José M Olivares, Joseph Peuskens, Cherilyn DeSouza, Chris M Kozma, Patrick Otten, Concetta Crivera, An Jacobs, Wayne Macfadden, Lian Mao, Stephen C Rodriguez, Riad Dirani and Kasem S Akhras

    Citation: Annals of General Psychiatry 2011 10:10

    Content type: Primary research

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  43. Due to the relationship between biology and culture, we believe that depression, understood as a cultural and existential phenomenon, has clear markers in molecular biology. We begin from an existential analys...

    Authors: Massimo Cocchi, Lucio Tonello, Fabio Gabrielli and Massimo Pregnolato

    Citation: Annals of General Psychiatry 2011 10:9

    Content type: Review

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  44. Anecdotal reports suggests that most clinicians treat medications as belonging to a class with regard to all therapeutic indications; this means that the whole 'class' of drugs is considered to possesses a spe...

    Authors: Konstantinos N Fountoulakis, Xenia Gonda, Eduard Vieta and Zoltan Rihmer

    Citation: Annals of General Psychiatry 2011 10:8

    Content type: Review

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  45. We assessed the impact of generalised anxiety disorder (GAD) on disability and health-related quality of life in outpatients treated in psychiatric clinics via a secondary analysis conducted in 799 patients fr...

    Authors: Julio Bobes, Luis Caballero, Inma Vilardaga and Javier Rejas

    Citation: Annals of General Psychiatry 2011 10:7

    Content type: Primary research

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  46. Perception of quality of life may differ depending on the perspective. The aim of the study was to assess the psychometric properties of the Spanish version of the 'TOlerability and quality Of Life' (TOOL) que...

    Authors: Angel L Montejo, Javier Correas Lauffer, Jesús Cuervo, Pablo Rebollo, Luis Cordero, Teresa Diez and Jorge Maurino

    Citation: Annals of General Psychiatry 2011 10:6

    Content type: Primary research

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