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  1. Factors influencing antidepressant treatment discontinuation are poorly understood. In the present study, we aimed to estimate the prevalence of antidepressant treatment discontinuation and identify demographi...

    Authors: Luis M. Garcia-Marin, Aoibhe Mulcahy, Enda M. Byrne, Sarah E. Medland, Naomi R. Wray, Freddy Chafota, Penelope A. Lind, Nicholas G. Martin, Ian B. Hickie, Miguel E. Rentería and Adrian I. Campos
    Citation: Annals of General Psychiatry 2023 22:49
  2. Treatment-resistant depression (TRD) is defined by the European Medicines Agency as a lack of clinically meaningful improvement after treatment, with at least two different antidepressants. Individual, familia...

    Authors: Giuseppe Maina, Marina Adami, Giuseppe Ascione, Emi Bondi, Domenico De Berardis, Dario Delmonte, Silvia Maffezzoli, Giovanni Martinotti, Alessandra Nivoli, Elena Ottavianelli and Andrea Fagiolini
    Citation: Annals of General Psychiatry 2023 22:48
  3. Major depressive disorder (MDD) poses a significant social and economic burden worldwide. Identifying exposures, risk factors, and biological mechanisms that are causally connected to MDD can help build a scie...

    Authors: Wang-ran Ma, Lei-lei Zhang, Jing-ying Ma, Fang Yu, Ya-qing Hou, Xiang-rui Feng and Lin Yang
    Citation: Annals of General Psychiatry 2023 22:47
  4. To evaluate the clinical efficacy and safety of Agomelatine in improving symptoms in patients with major depressive disorder (MDD), providing more scientific evidence for the treatment of depression, and offer...

    Authors: Ping Guo, Yong Xu, Liang Lv, Min Feng, Yu Fang, Wei-Quan Huang, Shan-Fei Cheng, Min-Cai Qian, Shengliang Yang, Shi-Kai Wang and Huan-Xin Chen
    Citation: Annals of General Psychiatry 2023 22:46
  5. There is a critical need for effective treatment of the core symptoms of autism spectrum disorder (ASD). The purinergic antagonist suramin may improve core symptoms through restoration of normal mitochondrial ...

    Authors: David Hough, Alice R. Mao, Michael Aman, Reymundo Lozano, Constance Smith-Hicks, Veronica Martinez-Cerdeno, Michael Derby, Zachary Rome, Niel Malan and Robert L. Findling
    Citation: Annals of General Psychiatry 2023 22:45
  6. The digital transformation has made its way into many areas of society, including medicine. While AI-based systems are widespread in medical disciplines, their use in psychiatry is progressing more slowly. How...

    Authors: Saskia Wilhelmy, Giancarlo Giupponi, Dominik Groß, Klaus Eisendle and Andreas Conca
    Citation: Annals of General Psychiatry 2023 22:43
  7. There is a conceptual overlap between negative and depressive symptoms, requiring further exploration to advance the understanding of negative symptoms. The aim of this study was to examine psychometric proper...

    Authors: Johan Bengtsson, Parya Rad, Martin Cernvall and Robert Bodén
    Citation: Annals of General Psychiatry 2023 22:42
  8. The COVID-19 pandemic emerged as an expected source of stress and anxiety as the healthcare workers had to work for long hours in close contact with infected patients, thus increasing the probability of medica...

    Authors: Hasan Nabil Al Houri, Abdullah Alhouri, Douaa Mohammad Nazir Arrouk, Ahmad Nabil Al Houri, Sami Jomaa, Alaa Sharabi, Hussein Kannout and Youssef Latifeh
    Citation: Annals of General Psychiatry 2023 22:41
  9. Schizophrenia is a serious mental disorder with complex clinical manifestations, while its pathophysiological mechanism is not fully understood. Accumulated evidence suggested the alteration in epigenetic path...

    Authors: Junjiao Ping, Jing Wan, Caiying Huang, Jinming Yu, Jiali Luo, Zhiqiang Xing, Xingguang Luo, Baoguo Du, Tingyun Jiang and Jie Zhang
    Citation: Annals of General Psychiatry 2023 22:40
  10. In Kalhbaum's first characterization of catatonia, the emotional symptoms, such as decreased or restricted expression of feelings and emotions, which is described as blunted affect, are related to the motor sy...

    Authors: Antonino Messina, Filippo Caraci, Eugenio Aguglia and Maria Salvina Signorelli
    Citation: Annals of General Psychiatry 2023 22:39
  11. The coronavirus disease 2019 (COVID-19) pandemic was reported to have increased depression among university students which was associated with impairments in their campus lives. This study examined changes in ...

    Authors: N. Shiraishi, M. Sakata, R. Toyomoto, K. Yoshida, Y. Luo, Y. Nakagami, A. Tajika, T. Watanabe, E. Sahker, T. Uwatoko, T. Shimamoto, T. Iwami and T. A. Furukawa
    Citation: Annals of General Psychiatry 2023 22:38
  12. Blonanserin (BNS) had been undergoing post-market surveillance (PMS) since September 2018. Using the surveillance data, we did this analysis to assess the safety and effectiveness of different doses of BNS to ...

    Authors: Yuan Yang, Hongmin Ge, Xijin Wang, Xuejun Liu, Keqing Li, Gang Wang, Xiaodong Yang, Huaili Deng, Meijuan Sun, Ruiling Zhang, Jindong Chen, Duanfang Cai, Hong Sang, Xianglai Liu, Guilai Zhan, Guijun Zhao…
    Citation: Annals of General Psychiatry 2023 22:37
  13. Many patients with depression refuse treatment. Moreover, suicide attempters often display low perceived need of treatment and impaired decision-making. These observations raise questions about the capacity to...

    Authors: Emilie Olié, Thomas Catanzaro, Manon Malestroit, Julio A. Guija, Lucas Giner and Philippe Courtet
    Citation: Annals of General Psychiatry 2023 22:35
  14. Risperidone ISM® is a newly developed long-acting injectable (LAI) treatment for schizophrenia in adults. In the absence of head-to-head comparisons with other similar antipsychotics, the objective of this study ...

    Authors: Pedro Sánchez, Cecilio Álamo, Marcos Almendros, Max Schlueter, Anastasios Tasoulas and Javier Martínez
    Citation: Annals of General Psychiatry 2023 22:33
  15. Major depressive disorder (MDD) is the most common mood disorder and a leading cause of disability worldwide. Trazodone, a triazolopyridine serotonin receptor antagonist and reuptake inhibitor (SARI) antidepre...

    Authors: Andrea Fagiolini, Ana González-Pinto, Kamilla Woznica Miskowiak, Pedro Morgado, Allan H. Young and Eduard Vieta
    Citation: Annals of General Psychiatry 2023 22:32
  16. In China, adolescents account for about a quarter of those treated for mental disorders each year, and adolescent mental health issues have become a social hotspot. Although several epidemiological surveys of ...

    Authors: Shuangyi Pei, Xiaoting Wu, Weijiang Ye, Linqi Fang, Haoqiang Zhang, Fanghua Zhou, Xiaofei Du, Xinyi Cao, Shengnan Ma, Yuanchu Li, Shuwen Xi and Pingping Xu
    Citation: Annals of General Psychiatry 2023 22:31
  17. In China, patients with somatoform disorders (SFD) often seek medical treatment repeatedly in outpatient clinics of general hospitals, which increases unreasonable medical expenses. It is imperative to provide...

    Authors: Xiangyun Yang, Jia Luo, Pengchong Wang, Yue He, Cong Wang, Lijuan Yang, Jing Sun and Zhanjiang Li
    Citation: Annals of General Psychiatry 2023 22:30
  18. Despite autism spectrum disorder (ASD) and mentalization being two words often associated in the literature, the assessment of this ability in individuals with ASD in the clinical setting is still limited. Ind...

    Authors: Ilenia Le Donne, Margherita Attanasio, Antony Bologna, Roberto Vagnetti, Francesco Masedu, Marco Valenti and Monica Mazza
    Citation: Annals of General Psychiatry 2023 22:29
  19. The aim of this meta-analysis was to determine global pooled prevalence of suicide thoughts and attempts in transgender population.

    Authors: Parisa Kohnepoushi, Maziar Nikouei, Mojtaba Cheraghi, Parsa Hasanabadi, Hamza Rahmani, Maryam Moradi, Ghobad Moradi, Farhad Moradpour and Yousef Moradi
    Citation: Annals of General Psychiatry 2023 22:28
  20. Gut microbiota is relevant to the pathogenesis of mental disorders including depression. This study aimed to investigate the influence of fluoxetine (FLX) on the gut microbiota in rats with Chronic Unpredictab...

    Authors: Hui Dong, Xiaowei Tang, Jie Ye and Wenhuan Xiao
    Citation: Annals of General Psychiatry 2023 22:27
  21. The objective of the present study was to examine the relationship between anxiety and sleep disorder during the COVID-19 pandemic and to evaluate whether sleep disorder is mediated by the decreased frequency ...

    Authors: Yumi Sugawara, Yutaka Yabe, Yoshihiro Hagiwara and Ichiro Tsuji
    Citation: Annals of General Psychiatry 2023 22:26
  22. Metabolic syndromes (MetS) are clinical syndromes involving multiple pathological states with distinct gender-specific clinical patterns. As a serious disorder associated with psychiatric conditions, the preva...

    Authors: Kuan Zeng, Shuo Wang, Lin Zhang, Yanting Zhang and Jun Ma
    Citation: Annals of General Psychiatry 2023 22:25
  23. The COVID-19 pandemic increased psychiatric distress and impacts differed by family structure. We aimed to identify mechanisms contributing to these inequalities.

    Authors: Michael J. Green, Peter Craig, Evangelia Demou, S. Vittal Katikireddi, Alastair H. Leyland and Anna Pearce
    Citation: Annals of General Psychiatry 2023 22:24
  24. Multiple sclerosis profoundly affects the sexual aspects of patients’ life, especially in women. Various coping strategies are used by women with multiple sclerosis to overcome, tolerate, or minimize these sex...

    Authors: Samaneh Imanpour Barough, Hedyeh Riazi, Zohreh Keshavarz, Maliheh Nasiri and Ali Montazeri
    Citation: Annals of General Psychiatry 2023 22:22
  25. The purine system represented by uric acid may be involved in the pathogenesis of bipolar disorder, This study intends to explore the association of serum uric acid levels with bipolar disorder in Chinese pati...

    Authors: Haihan Chen, Fengli Sun and Weidong Jin
    Citation: Annals of General Psychiatry 2023 22:20
  26. Coronavirus-19 disease (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Respiratory viruses damage not only the upper respiratory tract in humans, but also several diff...

    Authors: Leonardo Roever, Bruno Raphael Ribeiro Cavalcante and Alex Cleber Improta-Caria
    Citation: Annals of General Psychiatry 2023 22:19
  27. Borderline personality disorder (BPD) is characterized by impairments in emotion regulation, impulse control, and interpersonal and social functioning along with a deficit in emotional awareness and empathy. I...

    Authors: Saba Amiri, Fatemeh Sadat Mirfazeli, Jordan Grafman, Homa Mohammadsadeghi, Mehrdad Eftekhar, Nazila Karimzad, Maryam Mohebbi and Shabnam Nohesara
    Citation: Annals of General Psychiatry 2023 22:18
  28. In the field of psychiatric crisis interventions, treatment is commonly provided by multidisciplinary teams in Western countries. However, empirical data on the processes involved in this type of intervention ...

    Authors: Caroline Dedeystère Pobelov, Orest Weber, Sonia Krenz, Yves Dorogi and Laurent Michaud
    Citation: Annals of General Psychiatry 2023 22:17
  29. As a result of the public health measures put in place during the COVID-19 pandemic in Canada, many health services, including those for the treatment of eating disorders, were provided at a distance. This stu...

    Authors: Kaylee Novack, Rachel Dufour, Louis Picard, Danielle Taddeo, Pierre-Olivier Nadeau, Debra K. Katzman, Linda Booij and Nicholas Chadi
    Citation: Annals of General Psychiatry 2023 22:16
  30. Sexual dysfunction is a common side effect of Serotonergic antidepressants (SA) treatment, and persists in some patients despite drug discontinuation, a condition termed post-SSRI sexual dysfunction (PSSD). Th...

    Authors: Joseph Ben-Sheetrit, Yehonathan Hermon, Shlomo Birkenfeld, Yehiel Gutman, Antonei B. Csoka and Paz Toren
    Citation: Annals of General Psychiatry 2023 22:15
  31. Bipolar disorder is a severe and chronic mental illness that could continue for a lifetime. Although it is a leading cause of disability and impairments for significant numbers of patients, the levels of funct...

    Authors: Melak Erara Mengistu, Simegnew Handebo Berassa, Abebe Tarekegn Kassaw, Ephrem Mebratu Dagnew, Gizework Alemnew Mekonen and Mequanent Kassa Birarra
    Citation: Annals of General Psychiatry 2023 22:14
  32. Bipolar disorder is associated with functional impairment and diminished health-related quality of life (HRQoL). The purpose of this study was to estimate the annual per patient direct healthcare costs, indire...

    Authors: Carole Dembek, deMauri Mackie, Kushal Modi, Yingying Zhu, Xiaoli Niu and Todd Grinnell
    Citation: Annals of General Psychiatry 2023 22:13
  33. Despite a high number of studies investigating the correlation between long Duration of Untreated Illness (DUI) and poor course of Bipolar Disorder (BD), the results concerning the impact of DUI on some specif...

    Authors: Gabriele Di Salvo, Giorgia Porceddu, Umberto Albert, Giuseppe Maina and Gianluca Rosso
    Citation: Annals of General Psychiatry 2023 22:12
  34. The serotonergic and the endocannabinoid system are involved in the etiology of depression. Depressive patients exhibit low serotonergic activity and decreased level of the endocannabinoids anandamide (AEA) an...

    Authors: Barbara Emons, Larissa Arning, Vera-Estelle Makulla, Maria-Theresia Suchy, Dimitrios Tsikas, Thomas Lücke, Jörg T. Epplen, Georg Juckel and Patrik Roser
    Citation: Annals of General Psychiatry 2023 22:11
  35. There is considerable interest in exploring effects of coronavirus disease 2019 (COVID-19) pandemic on mental health. Suicide is one of the leading causes of mortality worldwide and changes in daily life broug...

    Authors: Tommaso Barlattani, Chiara D’Amelio, Francesco Capelli, Simonetta Mantenuto, Rodolfo Rossi, Valentina Socci, Paolo Stratta, Ramona Di Stefano, Alessandro Rossi and Francesca Pacitti
    Citation: Annals of General Psychiatry 2023 22:10
  36. The emotional regulation process plays a pivotal role in daily-life functioning, modulating goal-directed and adaptive behavior. Conversely, altering this cognitive function can disrupt self-regulation and bri...

    Authors: Giulia D’Aurizio, Ramona Di Stefano, Valentina Socci, Alessandro Rossi, Tommaso Barlattani, Francesca Pacitti and Rodolfo Rossi
    Citation: Annals of General Psychiatry 2023 22:9
  37. Leisure activities can improve quality of life in the general population. For people with psychosis, negative symptoms (e.g. being unmotivated, difficulty in sticking with activities) are often a barrier to en...

    Authors: Kayonda Hubert Ngamaba, Martin Webber, Penny Xanthopoulou, Agnes Chevalier and Domenico Giacco
    Citation: Annals of General Psychiatry 2023 22:8
  38. It remains unclear whether COVID-19 which is an infectious disease caused by the SARS-CoV-2 virus is associated with the deterioration of cognitive function among patients with schizophrenia. This study aimed ...

    Authors: Chadia Haddad, Angela Chamoun, Hala Sacre, Souheil Hallit, Pascale Salameh and Benjamin Calvet
    Citation: Annals of General Psychiatry 2023 22:7
  39. Comorbid metabolic disorders in patients with schizophrenia are very common. Patients with schizophrenia who respond to therapy early are often strongly predictive of better treatment outcomes. However, the di...

    Authors: Junhong Zhu, Jiajia Wu, Xuebing Liu and Jun Ma
    Citation: Annals of General Psychiatry 2023 22:6
  40. It is uncertain whether depression might affect cognitive function in Alzheimer’s disease (AD). Most of studies on the effect of depression treatment on cognitive function in AD were briefly evaluated by Mini-...

    Authors: Kyung Hee Yoon, Yoo Sun Moon and Do Hoon Kim
    Citation: Annals of General Psychiatry 2023 22:4
  41. Sleep disorders are common during the outbreak of pandemic diseases, and similar disorders are noted in hospitalized COVID-19 patients. It is valuable to explore the clinical manifestations and risk factors fo...

    Authors: Cun Li, Hong-bin Cai, Qing Zhou, Hua-qiu Zhang, Man Wang and Hui-cong Kang
    Citation: Annals of General Psychiatry 2023 22:3
  42. Interpersonal violence (IPV) is found to be associated with mental health problems and pain disorders such as headache among children and adolescents. It is well-known that adolescents in need of mental health...

    Authors: Hanne Klæboe Greger, Sara Konstanse Kristianslund and Synne Øien Stensland
    Citation: Annals of General Psychiatry 2023 22:2
  43. Definition of an appropriate and personalized treatment plan focused on long-term outcomes is crucial in the management of schizophrenia. Following review of the literature, a panel of six leading psychiatrist...

    Authors: Antonio Vita, Andrea Fagiolini, Giuseppe Maina, Claudio Mencacci, Edoardo Spina and Silvana Galderisi
    Citation: Annals of General Psychiatry 2023 22:1
  44. Several guidelines recommend monotherapy in pharmacotherapy for schizophrenia and major depressive disorder. The content of regular prescriptions has been reported in several studies, but not enough research h...

    Authors: Yoshitaka Kyou, Norio Yasui-Furukori, Naomi Hasegawa, Kenta Ide, Kayo Ichihashi, Naoki Hashimoto, Hikaru Hori, Yoshihito Shimizu, Yayoi Imamura, Hiroyuki Muraoka, Hitoshi Iida, Kazutaka Ohi, Yuka Yasuda, Kazuyoshi Ogasawara, Shusuke Numata, Jun-ichi Iga…
    Citation: Annals of General Psychiatry 2022 21:52