Physical anhedonia in the acute phase of schizophrenia

Background The aim of the current study is to investigate the relationship between physical anhedonia and psychopathological parameters, pharmacological parameters or motor side-effects in a sample of inpatients with schizophrenia in an acute episode of their illness. Method Eighty one patients with schizophrenia, consecutively admitted, with an acute episode of their illness, at the Eginition Hospital, Department of Psychiatry, University of Athens, during a one-year period were investigated regarding possible relationships between physical anhedonia, social-demographic data and clinical parameters as well as motor side-effects, induced by antipsychotic agents. All patients were assessed using the Chapman Revised Physical Anhedonia Scale (RPAS), the Positive and Negative Syndrome Scale (PANSS), the Rating Scale for Extrapyramidal Side-Effects (EPSE), the Barnes Akathisia Rating Scale (BARS) and the Abnormal Involuntary Movement Scale (AIMS). Simple cross tabulations were initially employed. Subsequently, multiple regression analysis was performed. Results Both positive and negative symptoms were associated with physical anhedonia. A positive association between physical anhedonia and the non-paranoid sub-category of schizophrenia was also proved. Conclusion According to these results, it seems that in the acute phase of schizophrenia, physical anhedonia may be a contributing factor to patient's psychopathology.


Background
Anhedonia, a term first used by Ribot [1], describes the lack of interest and the withdrawal from all the usual and pleasant activities. Anhedonia has been described as a schizophrenic symptom by many authors, including Bleuler and Kraepelin [2,3]. Rado [4,5] had suggested that anhedonia is a central, genetically transmitted defect both in overt schizophrenia and in compensated schizotypes. Meehl [6] has integrated Rado's views into a theory of neurological dysfunction in schizophrenia and proposed that anhedonia is an enduring trait, a "cardinal symptom" preceding and possibly causing schizophrenia.
According to Chapman et al [7], there are two types of anhedonia, physical anhedonia and social anhedonia. Physical anhedonia which, usually, precedes the onset of the disease, represents a defect in the ability to experience physical pleasures, such as pleasures of eating, touching e. t. c., while social anhedonia represents a defect in the ability to experience interpersonal pleasure, such as pleasure of being with people, talking e. t. c.
There have been contradictory results regarding the association of anhedonia or its components to clinical parameters (i.e. negative symptoms, positive symptoms, depression) or to drug -treatment. Furthermore, there is a lack of studies regarding the relationship between physical anhedonia and psychopathological parameters in the acute phase of schizophrenia or between physical anhedonia and motor side -effects induced by antipsychotic agents.
The aim of the current study was to investigate the relationship between physical anhedonia and social-demographic, clinical parameters as well as motor side-effects in a sample of inpatients with schizophrenia in the acute phase of their illness.

Subjects
All patients with schizophrenia, consecutively admitted, with an acute episode of their illness, at the Eginition Hospital, Department of Psychiatry, University of Athens, during a one-year period were studied. Written informed consent was obtained from the subjects and their relatives.
The patients' diagnoses were made by two independent psychiatrists of similar level of education and experience according to DSM-IV criteria [8] and were reviewed on the day of discharge, taking into account all information collected during the inpatient period. Patients who presented with any other diagnosis on Axis I of DSM-IV, serious physical illness (especially neurological), substance abuse and mental retardation were excluded from the study.
Means and standard deviations of the main variables are shown in table 1.
Subjects were assessed during the first week of their hospitalisation by three independent psychiatrists-raters. The first rater assessed the patients using the RPAS and the AIMS, the second using the PANSS and the EPSE and the third using the BARS. Information from the patient's history, concerning social-demographic and clinical parameters was recorded in a pre-coded interview form. The antipsychotic agents dosage was estimated in chlorpromazine equivalents [18,19].

Statistical analyses
The SPSS 8.0 was used for the statistical analysis. Since there is no cut-off point for schizophrenia, dividing anhedonic subjects from non-anhedonic ones, physical anhedonia scores were divided in thirtiles according to the ratings in rPAS (1 st thirtile: <15 and <14, 2 nd thirtile: 16-22 and 15-21, 3 rd thirtile: >23 and >22 for men and women respectively). Then, possible correlations were explored between: physical anhedonia and social-demographic parameters (i.e. sex, age, family status e.t.c.), clinical parameters (i.e. diagnostic sub-category) and psychopathological parameters derived from the aforementioned scales and their subscales used. Simple cross tabulations were initially employed. Of all the parameters cross-tabulated with physical anhedonia, statistically significant differences between subjects with lower anhedonia scores and subjects with higher anhedonia scores were found only for the PANSS positive sub-scale score, the PANSS negative sub-scale score and the dianostic sub-category parameter. Subsequently, multiple regression analysis was performed, using as predictor core model the following variables: gender, age, family status, diagnosis and years of education and diagnostic sub-category. Alternative introduced clinical standard variables to the core model were the PANSS positive sub-scale score and the PANSS negative sub-scale score. The physical anhedonia score was the dependent variable.

Results
Tables 2 shows the distribution of the sample crossclassified by sociodemographic, clinical variables and the physical anhedonia score thirtiles. The severity of physical anhedonia was significantly related to the diagnostic subcategory of non-paranoid schizophrenia, to the positive symptoms score and to the negative symptoms score of the PANSS. Table 3 shows the associations of physical anhedonia scores with the core model variables and the multiple regression analysis results. There were statistically significant associations of physical anhedonia scores with alternative clinical variables which were introduced to the core model. Single patients tended to have higher scores of physical anhedonia than others (p = 0.05). Older patients tended to score higher on physical anhedonia (p = 0.05). Patients with paranoid schizophrenia had lower scores of physical anhedonia than non-paranoid patients with schizophrenia (p = 0.004). Both positive symptoms score and negative symptoms score were positive predictors of physical anhedonia (P = 0.03 and P = 0.01, respectively).

Discussion
This is the first study searching simultaneously for possible association between physical anhedonia and positive symptoms, negative symptoms or general psychopathol- Starting with, we should mention several limitations of our study. First, we used a mixed population of patients with schizophrenia regarding their medication status. Second, there was a lack of a specific scale measuring depression in schizophrenia. Third, we studied patients in the acute phase of their illness. Hence, it was possible that positive symptoms may dominate and overlap the clinical manifestation of the disease.
According to our results, the severity of physical anhedonia was associated with the severity of both positive and negative symptoms. Also, a positive association between physical anhedonia and the sub-category of non-paranoid schizophrenia was presented. However, the severity of physical anhedonia was found to be independent to depression, to general psychopathology symptoms or motor side-effects induced by antipsychotic agents.
Regarding the relationship of physical anhedonia and negative symptoms the results are in line with those by Loas et al [20] and Kirkpatrick et al [21] who have demon-strated that physical anhedonia and deficit symptoms, which are described as enduring negative symptoms, were significantly related. Yet, Herbener et al [22] found that the PAS score of patients with schizophrenia was significantly correlated to negative symptoms, estimated by the SADS structured interview, at the 4.5 year follow up assessment. However, contrary to our results, Loas et al [23] found that physical anhedonia in chronic patients with schizophrenia was not significantly related to negative symptoms, estimated by both the PANSS and the BPRS. Other studies, as well, have reported an absence of significant correlation between physical anhedonia and negative symptoms as measured by the Positive and Negative Symptoms Scale (PANSS), the Brief Psychiatric Rating Scale (BPRS), or the SANS [24][25][26].
Regarding the relationship of physical anhedonia and positive symptoms, contrary to our results, Herbener et al [22] found that the PAS score of patients with schizophrenia was not correlated to florid psychotic symptoms, estimated by the SADS, over a 10 -year follow up period. Also, Loas et al [23] found that physical anhedonia in chronic patients with schizophrenia was not significantly related to positive symptoms, estimated by both the PANSS and the BPRS.
Regarding the relationship of physical anhedonia and the non-paranoid sub-type of schizophrenia, contrary to our results, Schunck et al [27] did not find a correlation between the PAS score and the schizophrenia sub-type in a sample of out-patients with schizophrenia.
The observation that physical anhedonia is independent of depression in schizophrenia seems to be consistent with the findings of Herbener et al [22]. They used a subscale of the SADS to estimate depression. Also, Loas et al [23] have found that physical anhedonia in chronic patients with schizophrenia was not significantly related to depression, estimated by the Beck Depression Inventory.
Regarding the relationship of physical anhedonia and general psychopatology symptoms, similar to our results are the findings of Loas et al [23] who have found that physical anhedonia in chronic patients with schizophrenia was not significantly related to general psychopathology symptoms, estimated by both the PANSS and the BPRS.
We did not find any studies exploring the the relationship between physical anhedonia and motor side effects induced by antipsychotic agents.