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  1. Post-COVID-19 Condition (PCC), as defined by the World Health Organization (WHO), currently lacks any regulatory-approved treatments and is characterized by persistent and debilitating cognitive impairment and...

    Authors: Angela T.H. Kwan, Gia Han Le, Ziji Guo, Felicia Ceban, Kayla M. Teopiz, Taeho Greg Rhee, Roger Ho, Joshua D. Di Vincenzo, Sebastian Badulescu, Shakila Meshkat, Bing Cao, Joshua D. Rosenblat, Donovan A. Dev, Lee Phan, Mehala Subramaniapillai and Roger S. McIntyre
    Citation: Annals of General Psychiatry 2024 23:10
  2. Studies suggest a correlation between excessive sedentary behavior, insufficient physical activity, and an elevated likelihood of experiencing psychiatric disorder. Nonetheless, the precise influence of sedent...

    Authors: Hongjun Ba, Lili Zhang, Huimin Peng, Xiufang He and Yao Wang
    Citation: Annals of General Psychiatry 2024 23:9
  3. Major depressive disorder (MDD) is predicted to become the second most common cause of disability in the near future. Exposure to glyphosate (Gly)-based herbicides has been linked to the onset of MDD. However,...

    Authors: Jianan Li and Haoran Bi
    Citation: Annals of General Psychiatry 2024 23:8
  4. Facing suicide risk is probably the most difficult task for clinicians when dealing with patients in crisis. It requires professional, intellectual, and emotional efforts. Suicide risk assessment can sometimes...

    Authors: Maurizio Pompili
    Citation: Annals of General Psychiatry 2024 23:6
  5. Being one of the most widespread, pervasive, and troublesome illnesses in the world, depression causes dysfunction in various spheres of individual and social life. Regrettably, despite obtaining evidence-base...

    Authors: Yupei Hao, Jinyuan Zhang, Jing Yu, Ze Yu, Lin Yang, Xin Hao, Fei Gao and Chunhua Zhou
    Citation: Annals of General Psychiatry 2024 23:5
  6. The present study aimed at assessing the prevalences of post-traumatic stress disorder (PTSD) (main objective), anxiety, depression, and burnout syndrome (BOS) and their associated factors in intensive care un...

    Authors: Claire Roger, Lowel Ling, Mélissa Petrier, Loubna Elotmani, Enora Atchade, Bernard Allaouchiche, Frédéric Aubrun, Jean-Michel Constantin, Claire Dahyot-Fizelier, Nathalie Delhaye, Hervé Dupont, Marc-Olivier Fischer, Marc Garnier, Etienne Gayat, Carole Ichai, Samir Jaber…
    Citation: Annals of General Psychiatry 2024 23:3
  7. A change of therapy from one to another antipsychotic medication is currently the main challenge of therapy. This study aimed to assess the prevalence of antipsychotic medication switches and determinants amon...

    Authors: Mekdes Kiflu, Telake Azale, Kale Gubae, Samuel Agegnew Wondm, Ephrem Mebratu, Asrat EliasErgena, Ousman Abubeker and Gizework Alemnew Mekonnen
    Citation: Annals of General Psychiatry 2024 23:2
  8. Weight gain in the months/years after diagnosis/treatment of severe enduring mental illness (SMI) is a major predictor of future diabetes, dysmetabolic profile and increased risk of cardiometabolic diseases. T...

    Authors: Adrian Heald, Chris Daly, John Julian Warner-Levy, Richard Williams, Cheyenne Meehan, Mark Livingston, Toby Pillinger, Lamiece Hussain and Joseph Firth
    Citation: Annals of General Psychiatry 2024 23:1
  9. It is known worldwide that stigma towards mental illness exists. Studies on stigma perceived by patients with mental illness have shown decreased quality of life and a negative impact on work, school and socia...

    Authors: Areej AlFattani, Lisa Bilal, Sami Y. Saad, Mohammad Talal Naseem, Sanaa Hyder, Abdulhamid Alhabib, Abdullah Alsubaie and Yasmin Altwaijri
    Citation: Annals of General Psychiatry 2023 22:54
  10. Major depressive disorder (MDD) is a leading mental disorder causing severe impairment. This study was aimed to evaluate sex difference in global MDD incidence by year, age, and socioeconomic status, according...

    Authors: Sangzi Li, Xuan Zhang, Yilu Cai, Leilei Zheng, Hu Pang and Lixia Lou
    Citation: Annals of General Psychiatry 2023 22:53
  11. Bipolar disorder is a mental illness characterized by recurring episodes of mania and depression and is known to cause social impairment. Additionally, it has been revealed that bipolar disorder increases the ...

    Authors: Keita Tokumitsu, Norio Sugawara, Naoto Adachi, Yukihisa Kubota, Yoichiro Watanabe, Kazuhira Miki, Takaharu Azekawa, Koji Edagawa, Eiichi Katsumoto, Seiji Hongo, Eiichiro Goto, Hitoshi Ueda, Masaki Kato, Reiji Yoshimura, Atsuo Nakagawa, Toshiaki Kikuchi…
    Citation: Annals of General Psychiatry 2023 22:52
  12. Major depressive disorder (MDD) is a major and common cause of suicide. The purpose of this article is to report the clinical characteristics and patterns of co-morbid suicidal behavior (SB) in first hospitali...

    Authors: Xianzhi Sun, Lili Yin, Yingying Zhang, Xuebing Liu and Jun Ma
    Citation: Annals of General Psychiatry 2023 22:51
  13. Bipolar disorder is one of the most burdensome severe mental disorders, characterized by high levels of personal and social disability. Patients often need an integrated pharmacological and non-pharmacological...

    Authors: Andrea Fiorillo, Gaia Sampogna, Umberto Albert, Giuseppe Maina, Giulio Perugi, Maurizio Pompili, Gianluca Rosso, Gabriele Sani and Alfonso Tortorella
    Citation: Annals of General Psychiatry 2023 22:50
  14. Factors influencing antidepressant treatment discontinuation are poorly understood. In the present study, we aimed to estimate the prevalence of antidepressant treatment discontinuation and identify demographi...

    Authors: Luis M. Garcia-Marin, Aoibhe Mulcahy, Enda M. Byrne, Sarah E. Medland, Naomi R. Wray, Freddy Chafota, Penelope A. Lind, Nicholas G. Martin, Ian B. Hickie, Miguel E. Rentería and Adrian I. Campos
    Citation: Annals of General Psychiatry 2023 22:49
  15. Treatment-resistant depression (TRD) is defined by the European Medicines Agency as a lack of clinically meaningful improvement after treatment, with at least two different antidepressants. Individual, familia...

    Authors: Giuseppe Maina, Marina Adami, Giuseppe Ascione, Emi Bondi, Domenico De Berardis, Dario Delmonte, Silvia Maffezzoli, Giovanni Martinotti, Alessandra Nivoli, Elena Ottavianelli and Andrea Fagiolini
    Citation: Annals of General Psychiatry 2023 22:48
  16. Major depressive disorder (MDD) poses a significant social and economic burden worldwide. Identifying exposures, risk factors, and biological mechanisms that are causally connected to MDD can help build a scie...

    Authors: Wang-ran Ma, Lei-lei Zhang, Jing-ying Ma, Fang Yu, Ya-qing Hou, Xiang-rui Feng and Lin Yang
    Citation: Annals of General Psychiatry 2023 22:47
  17. To evaluate the clinical efficacy and safety of Agomelatine in improving symptoms in patients with major depressive disorder (MDD), providing more scientific evidence for the treatment of depression, and offer...

    Authors: Ping Guo, Yong Xu, Liang Lv, Min Feng, Yu Fang, Wei-Quan Huang, Shan-Fei Cheng, Min-Cai Qian, Shengliang Yang, Shi-Kai Wang and Huan-Xin Chen
    Citation: Annals of General Psychiatry 2023 22:46
  18. There is a critical need for effective treatment of the core symptoms of autism spectrum disorder (ASD). The purinergic antagonist suramin may improve core symptoms through restoration of normal mitochondrial ...

    Authors: David Hough, Alice R. Mao, Michael Aman, Reymundo Lozano, Constance Smith-Hicks, Veronica Martinez-Cerdeno, Michael Derby, Zachary Rome, Niel Malan and Robert L. Findling
    Citation: Annals of General Psychiatry 2023 22:45
  19. The digital transformation has made its way into many areas of society, including medicine. While AI-based systems are widespread in medical disciplines, their use in psychiatry is progressing more slowly. How...

    Authors: Saskia Wilhelmy, Giancarlo Giupponi, Dominik Groß, Klaus Eisendle and Andreas Conca
    Citation: Annals of General Psychiatry 2023 22:43
  20. There is a conceptual overlap between negative and depressive symptoms, requiring further exploration to advance the understanding of negative symptoms. The aim of this study was to examine psychometric proper...

    Authors: Johan Bengtsson, Parya Rad, Martin Cernvall and Robert Bodén
    Citation: Annals of General Psychiatry 2023 22:42
  21. The COVID-19 pandemic emerged as an expected source of stress and anxiety as the healthcare workers had to work for long hours in close contact with infected patients, thus increasing the probability of medica...

    Authors: Hasan Nabil Al Houri, Abdullah Alhouri, Douaa Mohammad Nazir Arrouk, Ahmad Nabil Al Houri, Sami Jomaa, Alaa Sharabi, Hussein Kannout and Youssef Latifeh
    Citation: Annals of General Psychiatry 2023 22:41
  22. Schizophrenia is a serious mental disorder with complex clinical manifestations, while its pathophysiological mechanism is not fully understood. Accumulated evidence suggested the alteration in epigenetic path...

    Authors: Junjiao Ping, Jing Wan, Caiying Huang, Jinming Yu, Jiali Luo, Zhiqiang Xing, Xingguang Luo, Baoguo Du, Tingyun Jiang and Jie Zhang
    Citation: Annals of General Psychiatry 2023 22:40
  23. In Kalhbaum's first characterization of catatonia, the emotional symptoms, such as decreased or restricted expression of feelings and emotions, which is described as blunted affect, are related to the motor sy...

    Authors: Antonino Messina, Filippo Caraci, Eugenio Aguglia and Maria Salvina Signorelli
    Citation: Annals of General Psychiatry 2023 22:39
  24. The coronavirus disease 2019 (COVID-19) pandemic was reported to have increased depression among university students which was associated with impairments in their campus lives. This study examined changes in ...

    Authors: N. Shiraishi, M. Sakata, R. Toyomoto, K. Yoshida, Y. Luo, Y. Nakagami, A. Tajika, T. Watanabe, E. Sahker, T. Uwatoko, T. Shimamoto, T. Iwami and T. A. Furukawa
    Citation: Annals of General Psychiatry 2023 22:38
  25. Blonanserin (BNS) had been undergoing post-market surveillance (PMS) since September 2018. Using the surveillance data, we did this analysis to assess the safety and effectiveness of different doses of BNS to ...

    Authors: Yuan Yang, Hongmin Ge, Xijin Wang, Xuejun Liu, Keqing Li, Gang Wang, Xiaodong Yang, Huaili Deng, Meijuan Sun, Ruiling Zhang, Jindong Chen, Duanfang Cai, Hong Sang, Xianglai Liu, Guilai Zhan, Guijun Zhao…
    Citation: Annals of General Psychiatry 2023 22:37
  26. Many patients with depression refuse treatment. Moreover, suicide attempters often display low perceived need of treatment and impaired decision-making. These observations raise questions about the capacity to...

    Authors: Emilie Olié, Thomas Catanzaro, Manon Malestroit, Julio A. Guija, Lucas Giner and Philippe Courtet
    Citation: Annals of General Psychiatry 2023 22:35
  27. Risperidone ISM® is a newly developed long-acting injectable (LAI) treatment for schizophrenia in adults. In the absence of head-to-head comparisons with other similar antipsychotics, the objective of this study ...

    Authors: Pedro Sánchez, Cecilio Álamo, Marcos Almendros, Max Schlueter, Anastasios Tasoulas and Javier Martínez
    Citation: Annals of General Psychiatry 2023 22:33
  28. Major depressive disorder (MDD) is the most common mood disorder and a leading cause of disability worldwide. Trazodone, a triazolopyridine serotonin receptor antagonist and reuptake inhibitor (SARI) antidepre...

    Authors: Andrea Fagiolini, Ana González-Pinto, Kamilla Woznica Miskowiak, Pedro Morgado, Allan H. Young and Eduard Vieta
    Citation: Annals of General Psychiatry 2023 22:32
  29. In China, adolescents account for about a quarter of those treated for mental disorders each year, and adolescent mental health issues have become a social hotspot. Although several epidemiological surveys of ...

    Authors: Shuangyi Pei, Xiaoting Wu, Weijiang Ye, Linqi Fang, Haoqiang Zhang, Fanghua Zhou, Xiaofei Du, Xinyi Cao, Shengnan Ma, Yuanchu Li, Shuwen Xi and Pingping Xu
    Citation: Annals of General Psychiatry 2023 22:31
  30. In China, patients with somatoform disorders (SFD) often seek medical treatment repeatedly in outpatient clinics of general hospitals, which increases unreasonable medical expenses. It is imperative to provide...

    Authors: Xiangyun Yang, Jia Luo, Pengchong Wang, Yue He, Cong Wang, Lijuan Yang, Jing Sun and Zhanjiang Li
    Citation: Annals of General Psychiatry 2023 22:30
  31. Despite autism spectrum disorder (ASD) and mentalization being two words often associated in the literature, the assessment of this ability in individuals with ASD in the clinical setting is still limited. Ind...

    Authors: Ilenia Le Donne, Margherita Attanasio, Antony Bologna, Roberto Vagnetti, Francesco Masedu, Marco Valenti and Monica Mazza
    Citation: Annals of General Psychiatry 2023 22:29
  32. The aim of this meta-analysis was to determine global pooled prevalence of suicide thoughts and attempts in transgender population.

    Authors: Parisa Kohnepoushi, Maziar Nikouei, Mojtaba Cheraghi, Parsa Hasanabadi, Hamza Rahmani, Maryam Moradi, Ghobad Moradi, Farhad Moradpour and Yousef Moradi
    Citation: Annals of General Psychiatry 2023 22:28
  33. Gut microbiota is relevant to the pathogenesis of mental disorders including depression. This study aimed to investigate the influence of fluoxetine (FLX) on the gut microbiota in rats with Chronic Unpredictab...

    Authors: Hui Dong, Xiaowei Tang, Jie Ye and Wenhuan Xiao
    Citation: Annals of General Psychiatry 2023 22:27
  34. The objective of the present study was to examine the relationship between anxiety and sleep disorder during the COVID-19 pandemic and to evaluate whether sleep disorder is mediated by the decreased frequency ...

    Authors: Yumi Sugawara, Yutaka Yabe, Yoshihiro Hagiwara and Ichiro Tsuji
    Citation: Annals of General Psychiatry 2023 22:26
  35. Metabolic syndromes (MetS) are clinical syndromes involving multiple pathological states with distinct gender-specific clinical patterns. As a serious disorder associated with psychiatric conditions, the preva...

    Authors: Kuan Zeng, Shuo Wang, Lin Zhang, Yanting Zhang and Jun Ma
    Citation: Annals of General Psychiatry 2023 22:25
  36. The COVID-19 pandemic increased psychiatric distress and impacts differed by family structure. We aimed to identify mechanisms contributing to these inequalities.

    Authors: Michael J. Green, Peter Craig, Evangelia Demou, S. Vittal Katikireddi, Alastair H. Leyland and Anna Pearce
    Citation: Annals of General Psychiatry 2023 22:24
  37. Multiple sclerosis profoundly affects the sexual aspects of patients’ life, especially in women. Various coping strategies are used by women with multiple sclerosis to overcome, tolerate, or minimize these sex...

    Authors: Samaneh Imanpour Barough, Hedyeh Riazi, Zohreh Keshavarz, Maliheh Nasiri and Ali Montazeri
    Citation: Annals of General Psychiatry 2023 22:22
  38. The purine system represented by uric acid may be involved in the pathogenesis of bipolar disorder, This study intends to explore the association of serum uric acid levels with bipolar disorder in Chinese pati...

    Authors: Haihan Chen, Fengli Sun and Weidong Jin
    Citation: Annals of General Psychiatry 2023 22:20
  39. Coronavirus-19 disease (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Respiratory viruses damage not only the upper respiratory tract in humans, but also several diff...

    Authors: Leonardo Roever, Bruno Raphael Ribeiro Cavalcante and Alex Cleber Improta-Caria
    Citation: Annals of General Psychiatry 2023 22:19
  40. Borderline personality disorder (BPD) is characterized by impairments in emotion regulation, impulse control, and interpersonal and social functioning along with a deficit in emotional awareness and empathy. I...

    Authors: Saba Amiri, Fatemeh Sadat Mirfazeli, Jordan Grafman, Homa Mohammadsadeghi, Mehrdad Eftekhar, Nazila Karimzad, Maryam Mohebbi and Shabnam Nohesara
    Citation: Annals of General Psychiatry 2023 22:18
  41. In the field of psychiatric crisis interventions, treatment is commonly provided by multidisciplinary teams in Western countries. However, empirical data on the processes involved in this type of intervention ...

    Authors: Caroline Dedeystère Pobelov, Orest Weber, Sonia Krenz, Yves Dorogi and Laurent Michaud
    Citation: Annals of General Psychiatry 2023 22:17
  42. As a result of the public health measures put in place during the COVID-19 pandemic in Canada, many health services, including those for the treatment of eating disorders, were provided at a distance. This stu...

    Authors: Kaylee Novack, Rachel Dufour, Louis Picard, Danielle Taddeo, Pierre-Olivier Nadeau, Debra K. Katzman, Linda Booij and Nicholas Chadi
    Citation: Annals of General Psychiatry 2023 22:16
  43. Sexual dysfunction is a common side effect of Serotonergic antidepressants (SA) treatment, and persists in some patients despite drug discontinuation, a condition termed post-SSRI sexual dysfunction (PSSD). Th...

    Authors: Joseph Ben-Sheetrit, Yehonathan Hermon, Shlomo Birkenfeld, Yehiel Gutman, Antonei B. Csoka and Paz Toren
    Citation: Annals of General Psychiatry 2023 22:15