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Table 1 Monotherapy data on the efficacy of agents and classes of agents in different phases of bipolar illness

From: Class effect of pharmacotherapy in bipolar disorder: fact or misbelief?

Agent/modality (alphabetical order) Acute mania Acute bipolar depression Maintenance against mania Maintenance against depression
FGAs Class effect Unknown Uncertain class effect Unknown
Chlorpromazine Positive - - -
Haloperidol Positive - - -
Perphenazine - - Negative -
SGAs Class effect No class effect Class effect No class effect
Amisulpride - - - -
Aripiprazole Positive Negative Positive Negative
Asenapine Positive - - -
Clozapine Positive - - -
Olanzapine Positive Equivocal Positive Positive
Olanzapine-fluoxetine combination - Positive - -
Paliperidone Positive - - -
Quetiapine Positive Positive Positive Positive
Risperidone Positive - Positive -
Ziprasidone Positive - Positive -
Antiepileptics No class effect No class effect No class effect No class effect
Carbamazepine Positive Equivocal Equivocal Equivocal
Gabapentin Negative - - -
Lamotrigine Negative Negative Negative Positive
Licarbazepine Negative - - -
Topiramate Negative - - -
Valproate Positive Equivocal Equivocal Equivocal
Antidepressants Unknown No class effect Unknown No class effect
Fluoxetine - Positive - Positive
Paroxetine - Negative - -
Venlafaxine - Equivocal - -
  1. - = No data available.