Table 1 Monotherapy data on the efficacy of agents and classes of agents in different phases of bipolar illness
From: Class effect of pharmacotherapy in bipolar disorder: fact or misbelief?
Agent/modality (alphabetical order) | Acute mania | Acute bipolar depression | Maintenance against mania | Maintenance against depression |
|---|---|---|---|---|
FGAs | Class effect | Unknown | Uncertain class effect | Unknown |
Chlorpromazine | Positive | - | - | - |
Haloperidol | Positive | - | - | - |
Perphenazine | - | - | Negative | - |
SGAs | Class effect | No class effect | Class effect | No class effect |
Amisulpride | - | - | - | - |
Aripiprazole | Positive | Negative | Positive | Negative |
Asenapine | Positive | - | - | - |
Clozapine | Positive | - | - | - |
Olanzapine | Positive | Equivocal | Positive | Positive |
Olanzapine-fluoxetine combination | - | Positive | - | - |
Paliperidone | Positive | - | - | - |
Quetiapine | Positive | Positive | Positive | Positive |
Risperidone | Positive | - | Positive | - |
Ziprasidone | Positive | - | Positive | - |
Antiepileptics | No class effect | No class effect | No class effect | No class effect |
Carbamazepine | Positive | Equivocal | Equivocal | Equivocal |
Gabapentin | Negative | - | - | - |
Lamotrigine | Negative | Negative | Negative | Positive |
Licarbazepine | Negative | - | - | - |
Topiramate | Negative | - | - | - |
Valproate | Positive | Equivocal | Equivocal | Equivocal |
Antidepressants | Unknown | No class effect | Unknown | No class effect |
Fluoxetine | - | Positive | - | Positive |
Paroxetine | - | Negative | - | - |
Venlafaxine | - | Equivocal | - | - |