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Table 4 Serum cytokine concentrations in 41 women with perimenopausal depression, subdivided into those receiving (n = 19) or not (n = 22) selective serotonin reuptake inhibitors (SSRIs) compared to those women without perimenopausal depression (n = 24)

From: The role of cytokines and hot flashes in perimenopausal depression

Cytokine

Perimenopausal women with depression

Perimenopausal women without depression, N = 24

P value, Kruskal-Wallis

 

Not treated with SSRIs, N = 22

Treated with SSRIs, N = 19

  

TNFα

9.84 (2.3 to 21.90)

6.31 (4.08 to 9.23)

6.66 (3.01 to 16.50)

0.215, NS

IL-6

1.75 (1.13 to 2.95)

2.47 (1.59 to 4.67)

0.00 (0.00 to 5.63)

0.364, NS

IL-10

5.69 (3.39 to 12.00)

3.91 (1.08 to 10.20)

5.46 (1.31 to 12.90)

0.942, NS

  1. The results of cytokines are expressed as medians (10% to 90%). Unit of serum cytokine concentration is pg/ml.
  2. IL = interleukin; NS = not significant; TNF = tumor necrosis factor.