Table 1 Antipsychotic affinities ( K _i ) and target daily dosing range in schizophrenia [7, 9–11]

Ziprasidone

5HT_{2a (0.4)}

5HT_{1a (2.5) **}

α_{1 (13)}

D_{1 (130)}

M_{1 (5100)}

120-160 mg

5HT_{2c (0.7)}

D_{2 (3.1)}

D_{4 (32)}

α_{2 (310)}

D_{3 (7.2)}

H_{1 (47)}

5HT_{7 (9.3)}

NA_{uptake (48)}

5HT_{uptake (53)}

5HT_{6 (76)}

Aripiprazole

D_{2(0.3) **}

5HT_{1a (1.7) **}

D_{4 (44)}

M_{1 (>1000)}

15-30 mg

D_3(0.8)

5HT_2a(3.4)

5HT_{2c (15)}

5HT_{7 (39)}

α_{1 (57)}

H_{1 (61)}

5HT_{uptake (98)}

Risperidone

5HT_2a(0.3)

α_{1 (1.4)}

5HT_{2c (10)}

5HT_1A(210)

5HT_{uptake (1400)}

4-6 mg

D_{2 (2.2)}

H_{1 (19)}

D₁₍₅₈₀₎

5HT_{6 (2000)}

5HT_{7 (3.0)}

M_{1 (2800)}

D_{3 (9.6)}

NA_{uptake (28,000)}

D_{4 (8.5)}

α_{2 (5.1)}

Paliperidone

5HT_2a(1.0)

α_{2 (17)}

5HT_1A(590)

M_{1 (3570)}

6-9 mg

5HT_{7 (1.3)}

H_{1 (32)}

D₁₍₆₇₀₎

α_{1 (4.0)}

D_{4 (30)}

D_{2 (4.8)}

5HT_{2c (71)}

D_{3 (6.9)}

Olanzapine

H_1(2.8)

5HT_{2c (10)}

α_{2 (170)}

5HT_{1a (2100)}

10-20 mg

5HT_2a(3.3)

5HT_{6 (10)}

5HT_{7 (250)}

NA_{uptake (2000)}

M_1(4.7)

D_{2 (20)}

5HT_{uptake (>15,000)}

D_{3 (45)}

D_{1 (52)}

α_{1 (54)}

D_{4 (60)}

Clozapine

H_1(1.8)

5HT_{6 (11)}

D_{4 (54)}

5HT_{uptake (3900)}

200-500 mg

M_1(1.8)

5HT_{2c (17)}

D_{2 (130)}

α_{1 (4.0)}

α_{2 (33)}

5HT_{1a (140) **}

5HT_{2a (8.9)}

5HT_{7 (66)}

D_{3 (240)}

D_{1 (290)}

NA_{uptake (390) *}

Quetiapine

H_{1 (8.7)}

α_{1 (15)}

M_{1 (100)}

α_{2 (1000)}

400-800 mg

D_{2 (180)}

D_{1 (1300)}

5HT_{2a (220)}

5HT_{2c (1400)}

5HT_{1a (230) **}

5HT_{7 (1800)}

D_{3 (320)}

D_{4 (2200)}

NA_{uptake (680)*}

5HT_{6 (4100)}

5HT_{uptake (>18,000)}