Figure 2

Reported components of the definition for relapse. Hospitalization [11, 15–59]; Positive and Negative Syndrome Scale (PANSS) [7, 15, 17, 18, 60–72]; Clinical Global Impression (CGI) scale [17, 18, 26, 30, 52, 57, 60–62, 65],[66, 68, 71, 73, 74]; exacerbation/re-emergence of symptoms [7, 27, 29, 34, 38, 43, 63, 67],[75–81]; deliberate self-harm or violent behaviour, suicidal or homicidal ideation, arrest [18, 23, 27, 43, 49, 50, 57, 65],[66, 71, 74, 82–84]; Brief Psychiatric Rating Scale (BPRS) [28, 43, 71, 76, 84–91]; change of medication or patient management [18, 27, 38, 41, 56, 66, 75, 92]; exacerbation/re-emergence of symptoms leading to hospitalization [20, 66, 92–96]; clinical assessment of patient notes [38, 57, 88]; International Classification of Diseases (ICD) criteria [70, 89, 97]; Global Assessment of Functioning (GAF) [64, 72]; physician interview and/or assessment [86, 98]; Present State Examination (PSE) [84]; Global Assessment Scale (GAS) [84]; Target Symptoms Ratings Scale (TSRS) [76]; Psychiatric Assessment Scale (PAS) [99]; scale for the assessment of positive symptoms [86]; social functioning [75]; Social and Occupational Functioning Assessment Scale (SOFAS) [60].