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Table 1 The clinical rating scale scores, doses, and plasma concentrations of clozapine and aripiprazole

From: Aripirazole augmentation in clozapine-associated obsessive-compulsive symptoms in schizophrenia

  1st day 2nd week 3rd week 4th week PANSS Y-BOCS
Case 1: age 51, male 100 mg/day clozapine 100 mg/day clozapine 250 mg/day clozapine 250 mg/day clozapine Baseline Baseline
(90.7 ng/mL) (96.2 ng/mL) (215 ng/mL) (132.5 ng/mL) 151 40
+ + + + 4th week 4th week
30 mg/day aripiprazole 30 mg/day aripiprazole 30 mg/day aripiprazole 30 mg/day aripiprazole 50 20
  (222.2 ng/mL) (300.7 ng/mL) (322.8 ng/ml)   
Case 2: age 28, male 100 mg/day clozapine 200 mg/day clozapine 200 mg/day clozapine 100 mg/day clozapine Baseline Baseline
(142.8 ng/mL) (198.0 ng/mL) (332.7 ng/mL) (232 ng/mL) 78 40
+ + + + 4th week 4th week
30 mg/day aripiprazole 30 mg/day aripiprazole 30 mg/day aripiprazole 30 mg/day aripiprazole 49 15
  (100.78 ng/mL) (363.51 ng/mL) (368.23 ng/ml)   
Case 3: age 34, male 100 mg/day clozapine 150 mg/day clozapine 150 mg/day clozapine 100 mg/day clozapine Baseline Baseline
(52.7 ng/mL) (291.4 ng/mL) (749.1 ng/mL) (546.2 ng/mL) 141 40
+ + + + 4th week 4th week
30 mg/day aripiprazole 30 mg/day aripiprazole 15 mg/day aripiprazole 15 mg/day aripiprazole 50 20
  (787 ng/mL) (243 ng/mL) (310 ng/mL)   
Case 4: age 27, male 150 mg/day clozapine 200 mg/day clozapine 150 mg/d clozapine 100 mg/d clozapine Baseline Baseline
(142 ng/mL) (332 ng/mL) (241.7 ng/mL) (203.4 ng/mL) 159 30
+ + + + 4th week 4th week
30 mg/day aripiprazole 30 mg/day aripiprazole 30 mg/day aripiprazole 30 mg/day aripiprazole 46 10
   (353 ng/mL) (358.4 ng/mL) (347.8 ng/mL)