Table 1 The clinical rating scale scores, doses, and plasma concentrations of clozapine and aripiprazole
From: Aripirazole augmentation in clozapine-associated obsessive-compulsive symptoms in schizophrenia
1st day | 2nd week | 3rd week | 4th week | PANSS | Y-BOCS | |
|---|---|---|---|---|---|---|
Case 1: age 51, male | 100 mg/day clozapine | 100 mg/day clozapine | 250 mg/day clozapine | 250 mg/day clozapine | Baseline | Baseline |
(90.7 ng/mL) | (96.2 ng/mL) | (215 ng/mL) | (132.5 ng/mL) | 151 | 40 | |
+ | + | + | + | 4th week | 4th week | |
30 mg/day aripiprazole | 30 mg/day aripiprazole | 30 mg/day aripiprazole | 30 mg/day aripiprazole | 50 | 20 | |
(222.2 ng/mL) | (300.7 ng/mL) | (322.8 ng/ml) | ||||
Case 2: age 28, male | 100 mg/day clozapine | 200 mg/day clozapine | 200 mg/day clozapine | 100 mg/day clozapine | Baseline | Baseline |
(142.8 ng/mL) | (198.0 ng/mL) | (332.7 ng/mL) | (232 ng/mL) | 78 | 40 | |
+ | + | + | + | 4th week | 4th week | |
30 mg/day aripiprazole | 30 mg/day aripiprazole | 30 mg/day aripiprazole | 30 mg/day aripiprazole | 49 | 15 | |
(100.78 ng/mL) | (363.51 ng/mL) | (368.23 ng/ml) | ||||
Case 3: age 34, male | 100 mg/day clozapine | 150 mg/day clozapine | 150 mg/day clozapine | 100 mg/day clozapine | Baseline | Baseline |
(52.7 ng/mL) | (291.4 ng/mL) | (749.1 ng/mL) | (546.2 ng/mL) | 141 | 40 | |
+ | + | + | + | 4th week | 4th week | |
30 mg/day aripiprazole | 30 mg/day aripiprazole | 15 mg/day aripiprazole | 15 mg/day aripiprazole | 50 | 20 | |
(787 ng/mL) | (243 ng/mL) | (310 ng/mL) | ||||
Case 4: age 27, male | 150 mg/day clozapine | 200 mg/day clozapine | 150 mg/d clozapine | 100 mg/d clozapine | Baseline | Baseline |
(142 ng/mL) | (332 ng/mL) | (241.7 ng/mL) | (203.4 ng/mL) | 159 | 30 | |
+ | + | + | + | 4th week | 4th week | |
30 mg/day aripiprazole | 30 mg/day aripiprazole | 30 mg/day aripiprazole | 30 mg/day aripiprazole | 46 | 10 | |
(353 ng/mL) | (358.4 ng/mL) | (347.8 ng/mL) |