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Table 1 Positive results for gene-environment interactions behind antidepressant treatment response

From: Antidepressant treatment response is modulated by genetic and environmental factors and their interactions

Gene variant Interacting factor Outcome Sample size References Measuring methods
5-HTTLPR Stressful life events Escitalopram response 674 [10] Montgomery-Asberg Depression Rating Scale (MADRS),
List of Threatening Experiences questionnaire(LTE-Q)
5-HTTLPR Adverse life events Fluvoxamine response 159 [11] Hamilton Rating Scale for Depression (HAMD)
Life Events and Difficulty Schedule(LEDS)
SLC6A2 polymorphism Childhood abuse Antidepressant treatment response 308 [12] Hamilton Depression Rating Scale (HDRS-17)
Childhood Trauma Questionnaire(28 item Short Form, CTQ-SF)
5-HTR1B, TPH2 polymorphisms 5-HTR1B with negative life events, TPH2 with childhood trauma Antidepressant treatment response 308 [13] Hamilton Depression Rating Scale (HDRS-17)
Childhood Trauma Questionnaire(28-item Short Form, CTQ-SF)
Life Events Scale (LES)