Antidepressant treatment response is modulated by genetic and environmental factors and their interactions

Table 1 Positive results for gene-environment interactions behind antidepressant treatment response

Gene variant	Interacting factor	Outcome	Sample size	References	Measuring methods
5-HTTLPR	Stressful life events	Escitalopram response	674	[10]	Montgomery-Asberg Depression Rating Scale (MADRS),
5-HTTLPR	Stressful life events	Escitalopram response	674	[10]	List of Threatening Experiences questionnaire(LTE-Q)
5-HTTLPR	Adverse life events	Fluvoxamine response	159	[11]	Hamilton Rating Scale for Depression (HAMD)
5-HTTLPR	Adverse life events	Fluvoxamine response	159	[11]	Life Events and Difficulty Schedule(LEDS)
SLC6A2 polymorphism	Childhood abuse	Antidepressant treatment response	308	[12]	Hamilton Depression Rating Scale (HDRS-17)
SLC6A2 polymorphism	Childhood abuse	Antidepressant treatment response	308	[12]	Childhood Trauma Questionnaire(28 item Short Form, CTQ-SF)
5-HTR1B, TPH2 polymorphisms	5-HTR1B with negative life events, TPH2 with childhood trauma	Antidepressant treatment response	308	[13]	Hamilton Depression Rating Scale (HDRS-17)
					Childhood Trauma Questionnaire(28-item Short Form, CTQ-SF)
					Life Events Scale (LES)

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