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Lifetime comorbid anxiety in mania: structure factor, links with mixity and role of instable temperament

  • 1,
  • 2,
  • 3,
  • 4,
  • 5 and
  • 5
Annals of General Psychiatry20065(Suppl 1):S101

https://doi.org/10.1186/1744-859X-5-S1-S101

Published: 28 February 2006

Keywords

  • Depressive Symptom
  • Anxiety Disorder
  • Panic Disorder
  • Global Score
  • Acute Mania

Background

EPIMAN (n = 104 patients) study was dedicated to explore the dysphoric mixed mania. However, deriving data concerning the phenomenology of comorbid anxiety in mixed mania were lacking.

Materials and methods

"EPIMAN-II Thousand" is a national multi-site collaborative study dedicated to replicate and complete EPIMAN study (Hantouche et al., 2003). It involved training 317 French psychiatrists working in different sites representative of all France. The study actually succeeded in recruiting 1090 cases admitted for acute mania (DSM-IV criteria). Mixed Mania, as defined by the presence of 2 items from the checklist of depressive symptoms, CLDS (10 items) was observed in 30% of the entire population. Lifetime comorbid anxiety disorders were assessed by using the DSM-IV criteria, and the AMDP Anxiety Scale of Bobon. The full TEPMS-A French version (84 items, Hantouche et al., 2001) was used to assess the Affective Temperaments.

Results

In Mixed Mania, the rates of comorbid anxiety disorders were higher than in Pure Mania (especially GAD, 30.3% vs 14.3% Panic Disorder 7.9% vs 2.7% and PTSD 4.5% vs 0.9%). The PCA conducted on the AMDP scale revealed the presence of 3 major components: core factor "Dysphoric Inner Agitation" (9 items), "Psychic and Physical Anxiety" (7 items), and "Phobias" (2 items). The global score factor and factorial scores on AMDP were significantly higher in Mixed Mania versus Pure Mania (respectively 25.3 vs 17.1 and 15.5 vs 11.0 on F1, 10.3 vs 6.6 on F2 and 1.2 vs 0.7 on F3, p < 0.0001). Moreover, the different scores on AMDP were mostly correlated with the scores on Cyclothymic and Irritable Temperaments (stronger than with Depressive Temperament).

Discussion

Our data obtained on the largest population of manic patients ever conducted (n = 1090) confirmed the complex nature of comorbid anxiety within BP-I disorder, and suggested the significant relationship with Mixed Mania, and the major role of instable premorbid temperaments, such as cyclothymic and irritable.

Declarations

Acknowledgements

Funding source: unrestricted grant from Sanofi-Aventis.

Authors’ Affiliations

(1)
Mood Center, Université Paris VI, Pitie-Salpetriere Hospital, Paris, France
(2)
International Mood Center, UCSD, San Diego, USA
(3)
Sainte Marguerite Hospital, Marseille, France
(4)
Sylia-Stat, Antony, France
(5)
CNS Department Sanofi-Aventis, Paris, France

References

  1. Hantouche E, Kochman F, Akiskal HS: Evaluation des temperaments affectifs: version complete des outils d'auto-evaluation. Encephale. 2001, 27: 24-30.Google Scholar
  2. Hantouche E, Azorin KM, Chatenet-Duchene L: Caractérisation de la manie dans la cohorte nationale de 1090 patients de l'étude EPIMAN-II-Mille: frequence des sous-types, debut et errances diagnostiques. Annales Medico-Psychologiques. 2003, 161: 359-366. 10.1016/S0003-4487(03)00116-1.View ArticleGoogle Scholar

Copyright

© The Author(s) 2006

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