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Effect of agmatine on amigdala kindling in rats


Agmatine is an endogenous amine synthesized from L-arginine. Agmatine has been found to be anticonvulsive in maksimal electoconvulsive and pentilentetrazol-induced epilepsy models. The aim of the present study was to investigate the effect of agmatine on amigdala kindling in rats.

Materials and methods

Using a kindling model of epilepsy, we examined effect of agmatine in epileptic rats. Kindled epileptic rats were prepared by repeated, initially subconvulsive, electrical stimulations applied to the amygdala through a chronically implanted electrode, resulting in the establishment of a long-lasting epileptic focus.


Agmatine suppressed the development of the behavioral seizure score and afterdischarge (AD) duration recorded from the amygdala and cortex. Vehicle treated animals displayed grade V seizures at 12–15 stimulations. After 15 stimulations agmatine pretreated group (80 mg/kg) had only limbic seizures (grade II). None of the agmatine pretreated group had grade V after 30 stimulations which was cut-off.


These results indicate that agmatine as an endogenous substance plays an important role in the seizure expression mechanism and the development of kindling-induced epileptogenesis.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Aricioglu, F., Yananli, H., Berkman, K. et al. Effect of agmatine on amigdala kindling in rats. Ann Gen Psychiatry 5 (Suppl 1), S105 (2006).

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