Skip to main content


The concomitant use of venlafaxine and orphenadrine citrate plus paracetamol can produce acute cutaneous reaction: a case report study


Coadministration of various drugs together with antidepressants can induce different side-effects in depressed patients. The authors report the case of a middle-aged woman, suffering from recurrent unipolar mood disorder, who developed an acute cutaneous reaction after the concomitant use of venlafaxine 225 mg/day and a combination product of orphenadrine citrate 105 mg/day and paracetamol 1350 mg/day.

Materials and Methods

To address whether the occurrence of this cutaneous reaction was the result of a possible allergic reaction or a drug-drug interaction.

In an attempt to identify the origin of this adverse effect, skin prick tests were performed in the patient with orphenadrine citrate and paracetamol in multiple dilutions. Five non-depressed patients, without a medical history of atopy, to whom it was recently prescribed orphenadrine citrate and paracetamol, were evaluated and were used as controls.


Skin tests to orphenadrine citrate and paracetamol were negative both for the patient under consideration, as well as for the members of the control group. In addition, none of the individuals studied developed any delayed skin test reactions.


According to our findings, the possibility of an allergic reaction due to the concomitant use of venlafaxine and this combination product of orphenadrine citrate and paracetamol cannot be supported, since skin prick tests were negative. Thus, it is suggested that this cutaneous reaction is probably due to a drug-drug interaction between venlafaxine and this combination product.

Author information

Correspondence to George Papadimitriou.

Rights and permissions

Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and Permissions

About this article


  • Paracetamol
  • Allergic Reaction
  • Depressed Patient
  • Skin Test
  • Mood Disorder