Skip to main content

Clinical status course and quality of life after the first 2 years of treatment: results from the European Schizophrenia Outpatient Health Outcomes (SOHO) study

Background

European SOHO is a prospective, observational study of antipsychotic treatment in 10 European countries.

Materials and methods

Clinical effectiveness and Qol were assessed using the Clinical Global Impression (CGI) scale and the EQ-5D instrument, respectively. For analysis, the 2-year period was split into four 6-month epochs (0–6, 6–12, 12–18 and 18–24 months). Multivariate modelling was performed, adjusting for baseline differences among patients.

Results

Olanzapine-treated patients had statistically higher overall CGI improvements during i) the first 6 months, compared with risperidone (0.20; 0.14–0.26), quetiapine (0.24; 0.15–0.33), amisulpride (0.12; 0.00–0.23), oral (0.33; 0.25–0.41) and depot typicals (0.33; 0.24–0.42) treated patients, and ii) second 6 months compared with oral typicals (0.12; 0.04–0.19) treated patients. No statistical separation was observed between the olanzapine and clozapine groups.

Olanzapine-treated patients had statistically higher EQ-5D utility improvements during the first 6 months compared with risperidone (0.034; 0.015–0.053), quetiapine (0.033; 0.010–0.061), amisulpride (0.043; 0.006–0.080), oral (0.075; 0.050–0.100) and depot typicals (0.073; 0.045–0.102) treated patients. No statistical separation was observed between the olanzapine and clozapine groups.

Discussion

Olanzapine appears to have a range of modest effectiveness and Qol advantages, appearing during the first 6 months of treatment and remaining thereafter, over other antipsychotic medications, except clozapine.

Author information

Authors and Affiliations

Authors

Rights and permissions

Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and Permissions

About this article

Cite this article

Touloumis, C., Drossinos, V., Kyrana, M. et al. Clinical status course and quality of life after the first 2 years of treatment: results from the European Schizophrenia Outpatient Health Outcomes (SOHO) study. Ann Gen Psychiatry 5 (Suppl 1), S144 (2006). https://doi.org/10.1186/1744-859X-5-S1-S144

Download citation

  • Published:

  • DOI: https://doi.org/10.1186/1744-859X-5-S1-S144

Keywords

  • Clozapine
  • Risperidone
  • Olanzapine
  • Quetiapine
  • Statistical Separation