Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Effect of cyproheptadine on combat related PTSD nightmares

Background

Recent studies have shown the role serotonergic system in post-traumatic stress disorder. Trazodone and Nefazodone (5H2 antagonist) amilorated PTSD nightmares but the receptors are mixed. This study promoted an open trial of cyporoheptadine for Iran versus Iraq combat related PTSD patients nightmares.

Materials and methods

25 patients studies in 8 week, before after trial of cyproheptadine, the participant were male and chronic PTSD patients with combat related nightmares.

Results

5 patients were excluded from the study because of side effects including dizziness and somnolence. 20 patients completed the study. Average nightmare severity decreased from 6.85 to 5.05 which was statistically signifcant (p < 0.01).

Discussion

Cyproheptadine may be effective in PTSD nightmare treatment.

References

  1. 1.

    Harsh HH: Cyorheptatine for recurrent nighmares. Am J Psy. 1986, 143: 1491-1492.

Download references

Author information

Correspondence to Gholamhossien Ahmadzadeh.

Rights and permissions

Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and Permissions

About this article

Cite this article

Ahmadzadeh, G., Asadolahi, G., Mahmodi, G. et al. Effect of cyproheptadine on combat related PTSD nightmares. Ann Gen Psychiatry 5, S159 (2006). https://doi.org/10.1186/1744-859X-5-S1-S159

Download citation

Keywords

  • Public Health
  • Patient Study
  • Stress Disorder
  • Trazodone
  • Open Trial