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Toxoplasma gondii and schizophrenia

  • Mojgan Mokhtari1 and
  • Mohammadreza Mokhtari1
Annals of General Psychiatry20065(Suppl 1):S169

https://doi.org/10.1186/1744-859X-5-S1-S169

Published: 28 February 2006

Keywords

Public HealthClinical TrialSchizophreniaSerum SampleControl Case

Background

Infectious agents may contribute to some cases of schizophrenia. In animals, T. gondii infection can alter behaviour and neurotransmitter function. Establishing the role of T. gondii in etiopathogenesis of schizophrenia might lead to new medications for its prevention and treatment. The aim of this study is to evaluate the relation between schizophrenia and T. gondii in Iranian patients.

Materials and methods

Serum samples of 230 cases of schizophrenia and 230 of a matched control group were examined for Toxoplasma antibodies (IgG, IgM) by Elisa method. Data were analysed by Chi square and Odd ratio, and p value less than 0.05 was determined statistically significant.

Results

41 (17.8%) out of 230 patient cases and 17 (7.3%) out of 230 control cases were antibody positive. The difference was statistically meaningful. There were no differences between age groups and both genders.

Discussion

These findings indicate that T. gondii may play a role in the etiopathogenesis of some schizophrenic cases. Therefore, more basic studies and clinical trials are recommended to confirm this role.

Authors’ Affiliations

(1)
Esfahan University of Medical Sciences, Iran

References

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  2. Rantakalio P, Jones P, Moring J, Von Wendt L: Association between central nervous system infections during childhood and adult onset schizophrenia and other psychosis: A 28-year follow-up. Int Epidemol. 1997, 26: 837-843. 10.1093/ije/26.4.837.View ArticleGoogle Scholar
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Copyright

© The Author(s) 2006

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