- Poster presentation
- Open Access
Toxoplasma gondii and schizophrenia
© The Author(s) 2006
- Published: 28 February 2006
- Public Health
- Clinical Trial
- Serum Sample
- Control Case
Infectious agents may contribute to some cases of schizophrenia. In animals, T. gondii infection can alter behaviour and neurotransmitter function. Establishing the role of T. gondii in etiopathogenesis of schizophrenia might lead to new medications for its prevention and treatment. The aim of this study is to evaluate the relation between schizophrenia and T. gondii in Iranian patients.
Serum samples of 230 cases of schizophrenia and 230 of a matched control group were examined for Toxoplasma antibodies (IgG, IgM) by Elisa method. Data were analysed by Chi square and Odd ratio, and p value less than 0.05 was determined statistically significant.
41 (17.8%) out of 230 patient cases and 17 (7.3%) out of 230 control cases were antibody positive. The difference was statistically meaningful. There were no differences between age groups and both genders.
These findings indicate that T. gondii may play a role in the etiopathogenesis of some schizophrenic cases. Therefore, more basic studies and clinical trials are recommended to confirm this role.
- Yolken RH, Bachmann S, Roslanova I, Lillehoj E, Ford G, Torrey EF, Schroeder J: Antibodies to Toxoplasma gondii in individuals with first-episode schizophrenia. Clin Infect Dis. 2001, 32: 842-844. 10.1086/319221.View ArticlePubMedGoogle Scholar
- Rantakalio P, Jones P, Moring J, Von Wendt L: Association between central nervous system infections during childhood and adult onset schizophrenia and other psychosis: A 28-year follow-up. Int Epidemol. 1997, 26: 837-843. 10.1093/ije/26.4.837.View ArticleGoogle Scholar
- Leweke FM, Gerth CW, Koethe D, Klosterkotter J, Ruslanova I, Krivogorsky B, Torrey EF, Yolken RH: Antibodies to infectious agents in individuals with recent onset schizophrenia. Eur Arch Psychiatry Clin Neurosci. 2004, 254: 4-8. 10.1007/s00406-004-0481-6.View ArticlePubMedGoogle Scholar
- Yolken RH, Torrey EF: Viruses, schizophrenia, and bipolar disorder. Clin Microbial Rev. 1995, 8: 131-145.Google Scholar