Skip to main content

Toxoplasma gondii and schizophrenia

Background

Infectious agents may contribute to some cases of schizophrenia. In animals, T. gondii infection can alter behaviour and neurotransmitter function. Establishing the role of T. gondii in etiopathogenesis of schizophrenia might lead to new medications for its prevention and treatment. The aim of this study is to evaluate the relation between schizophrenia and T. gondii in Iranian patients.

Materials and methods

Serum samples of 230 cases of schizophrenia and 230 of a matched control group were examined for Toxoplasma antibodies (IgG, IgM) by Elisa method. Data were analysed by Chi square and Odd ratio, and p value less than 0.05 was determined statistically significant.

Results

41 (17.8%) out of 230 patient cases and 17 (7.3%) out of 230 control cases were antibody positive. The difference was statistically meaningful. There were no differences between age groups and both genders.

Discussion

These findings indicate that T. gondii may play a role in the etiopathogenesis of some schizophrenic cases. Therefore, more basic studies and clinical trials are recommended to confirm this role.

References

  1. Yolken RH, Bachmann S, Roslanova I, Lillehoj E, Ford G, Torrey EF, Schroeder J: Antibodies to Toxoplasma gondii in individuals with first-episode schizophrenia. Clin Infect Dis. 2001, 32: 842-844. 10.1086/319221.

    CAS  Article  PubMed  Google Scholar 

  2. Rantakalio P, Jones P, Moring J, Von Wendt L: Association between central nervous system infections during childhood and adult onset schizophrenia and other psychosis: A 28-year follow-up. Int Epidemol. 1997, 26: 837-843. 10.1093/ije/26.4.837.

    Article  Google Scholar 

  3. Leweke FM, Gerth CW, Koethe D, Klosterkotter J, Ruslanova I, Krivogorsky B, Torrey EF, Yolken RH: Antibodies to infectious agents in individuals with recent onset schizophrenia. Eur Arch Psychiatry Clin Neurosci. 2004, 254: 4-8. 10.1007/s00406-004-0481-6.

    Article  PubMed  Google Scholar 

  4. Yolken RH, Torrey EF: Viruses, schizophrenia, and bipolar disorder. Clin Microbial Rev. 1995, 8: 131-145.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and Permissions

About this article

Cite this article

Mokhtari, M., Mokhtari, M. Toxoplasma gondii and schizophrenia. Ann Gen Psychiatry 5, S169 (2006). https://doi.org/10.1186/1744-859X-5-S1-S169

Download citation

  • Published:

  • DOI: https://doi.org/10.1186/1744-859X-5-S1-S169

Keywords

  • Public Health
  • Clinical Trial
  • Schizophrenia
  • Serum Sample
  • Control Case