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Relations between pre- and perinatal agressions and early neurodevelopmental disorders


Our life, since intrauterine period, is a complex and permanent process of adaptation to internal and external stimuli. Multiple agressive factors acting during prenatal and perinatal period and can disturb normal development of the brain, some of them could be determined by stress. Structural cerebral disorders present in hypoxic-ischemic agressions can be similar with those described in early stress.

The objectives of the study are to make relations between pre-perinatal agressions and early neurodevelopment disorders (0–3 years).

Materials and methods

In a period of two years we evaluated all the infants admitted in Clinic of Pediatric Neurology Cluj-Napoca for psycho-motor retardation. The evaluation was complex clinical and paraclinical, the psychomotor development was evaluated with multifunctional test Munchen.


There were 200 infants, boys dominated (56%). We identified motor retardation — 68 infants (34%), psychic retardation — 10 infants (5%), global retardation — 122 infants (61%). On history and documents we identified aggressions (psychological, infectious, hypoxic-ischemic) — prenatal — 11 infants (5.5%), perinatal — 89 (44.5%), pre-perinatal — 23 (11.5%).


Intrauterine hypoxic aggression, even in the first months of pregnancy was related with mild motor retardation. Associated hypoxic agression pre-perinatal was related with more complex neurological disorders with global retardation or was revealed subjacent pathology — genetic or metabolic.

Prematurity was related with mild motor retardation, when was associated with perinatal hypoxic-ischemic aggression, it was identified more severe neurological disorders and global retardation.


1. Our study confirm other studies results that prematurity by itself do not determine brain damage. 2. The moment of birth is essential — it can revealed masked defects or can even "stressed" the brain with impact in neuropsychological development.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Adela, V.M., Ileana, B. Relations between pre- and perinatal agressions and early neurodevelopmental disorders. Ann Gen Psychiatry 5 (Suppl 1), S174 (2006).

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