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Regulation of stress – sequential micronutrition


Stress is a real public health issue because of multiples consequences which leads as well personal as collective. Bioresearch and Partners' objective is to exploit a new nutritional approach: micronutrition which can be used in acute as well as in chronic stress.

The micronutritional approach developed by Bioresearch and Partners is a new mode of utilizing nutrients which targets an action on the global regulation of stress; the nutrients have been selected to participate in a nutritional strategy aiming to help the organism in the regulation of stress homeostasis.

Materials and methods

This randomised, double-blind, placebo-controlled study verified the efficacy of micronutrition on 8-week treatment period in patients with generalized stress disorder.

The study group consisted of 158 subjects two groups (81 micronutrition, 77 placebos) average age: 42.5 (69 men, 89 women).

Subjects' symptoms were collected before treatment and after 8 weeks of treatment. Inclusion requires 18 minimum points (3 central and 3 somatic symptoms) in Hamilton Rating Scale for stress (HAM-S). Total score was measured and compared in the two groups.


After 8 weeks of follow-up, the total score decreased of 42.9% in the micronutrition group versus 19.7% in the placebo group. Total score : 2168 to 1238 for micronutrition group,1973 to 1585 for placebo group.65% of micronutrition group get out of the inclusion criteria (score under 18) versus 35% versus placebo.


Decreased of total score (HAM-S) corresponding in disappearance of intensity stress symptoms (42.9% versus 19.7%) offer a satisfactory response to the required therapeutic aims in a population presenting a generalized stress disorder.

Micronutrisequence is efficient in stress, and offer a new response in situations which do not always require drugs in cases other than pathologic situation requiring anxiolitic drug.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Marie, B. Regulation of stress – sequential micronutrition. Ann Gen Psychiatry 5 (Suppl 1), S193 (2006).

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