Volume 5 Supplement 1

International Society on Brain and Behaviour: 2nd International Congress on Brain and Behaviour

Open Access

Investigation of memory suppression in borderline personality disorder patients

  • Michela Sala1,
  • Elisa Marraffini2,
  • Marianna Boso2,
  • Matteo Balestrieri3,
  • Francesco Barale2,
  • Paolo Brambilla3 and
  • Edgardo Caverzasi2
Annals of General Psychiatry20065(Suppl 1):S206

https://doi.org/10.1186/1744-859X-5-S1-S206

Published: 28 February 2006

Background

Recently it has been suggested that hippocampus and dorsolateral prefrontal cortex (DLPFC) are involved in the mechanism of suppression of unwanted memories, which may play a key role in the pathophysiology of some psychopathological symptoms, like emotional instability, flashbacks and intrusive thoughts (Anderson et al. 2004). These symptoms are often seen in subjects with stress related disorders (Sala et al. 2004), such as Borderline Personality Disorder (BPD). This is a severe mental disorder characterized by mood instability, impulse discontrol, instability of personal relationships, being frequently associated with hystory of childhood traumatic experiences. However, although its pathophysiology is still largely unknown, some brain imaging studies reported structural and functional abnormalities of hippocampus and DLPFC in BPD patients (Brambilla et al. 2004; Driessen et al. 2000). In this ongoing study we are investigating whether the repression mechanism is affected in BPD, possibly in part sustaining the pathophysiology and the psychopathology of the disorder.

Materials and methods

The Anderson's paradigm, which explores the capacity of remembering and suppressing pair of words previously learned, is being administered to patients with BPD and healthy controls.

Results

Preliminary results will be presented at the congress.

Discussion

The think/no-think paradigm from Anderson et al. (Anderson and Green 2001) investigating hippocampal/DLPFC functioning in memory suppression may be helpful to study the memory repression mechanism in patients with BPD.

Authors’ Affiliations

(1)
Department of Physiological, Pharmacological and Cellular Sciences, University of Pavia
(2)
Department Of Health and Behavioural Sciences. Section Of Psychiatry, University of Pavia
(3)
Interuniversity Center for Behavioral Neurosciences, Department of Pathology and Clinical and Experim

References

  1. Anderson MC, Ochsner CN, Kulh B, Cooper J, Robertson E, Gabrieli SW, Glover GH, Gabrieli GDE: Neural systems underlying the suppression of unwanted memories. Science. 2004, 303: 232-235. 10.1126/science.1089504.View ArticlePubMedGoogle Scholar
  2. Driessen M, Herrmann J, Stahl K, Zwaan M, Meier S, Hill A, Osterheider M, Petersen D: Magnetic resonance imaging volumes of the hippocampus and the amygdala in women with borderline personality disorder and early traumatization. Arch Gen Psychiatry. 2000, 57: 1115-1122. 10.1001/archpsyc.57.12.1115.View ArticlePubMedGoogle Scholar
  3. Brambilla P, Soloff PH, Sala M, Nicoletti MA, Keshavan MS, Soares JC: Anatomical MRI study of borderline personality disorder patients. Psychiatry Res. 2004, 131: 125-133.View ArticlePubMedGoogle Scholar
  4. Sala M, Perez J, Soloff P, Ucelli di Nemi S, Caverzasi E, Soares JC, Brambilla P: Stress And Hippocampal Abnormalities In Psychiatric Disorders. European Neuropsychopharmacology. 2004, 14: 393-405. 10.1016/j.euroneuro.2003.12.005.View ArticlePubMedGoogle Scholar

Copyright

© The Author(s) 2006

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