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The comparison of topiramate and placebo in the treatment of posttraumatic stress disorder; randomized double blind study


Based on the kindling hypothesis of PTSD this double blind clinical trial assesses clinical response to Topiramate as a potential treatment.

Materials and methods

Sixty seven combat veterans with PTSD (30–50 years old S; 39.5 ± 4.19) randomly assigned in a double blind design. They were treated for 12 weeks with Topiramate (n = 33). Measures used in monthly assessments during 3 months of treatment included the clinician-Administered PTSD Scale (CAPS). Paired T-student Friedman and Willcoxon were used to data analysis.


Three patients were withdrawn from study because of Topiramate side effect. In remainders the mean score of Topiramate group in the first visit was 50.70 ± 7.7 and the mean score of placebo group was 48.9 ± 9.13. After finishing the treatment period the mean score of the the topiramate group was 32.75 ± 8.8. The analysis of these scores showed a significant difference between the groups(p = 0.00). In details: Frequency and intensity of reexperience criteria (intrusive memory nightmare and flash back) sleep problem irritability and anger and frequency of difficulty to recall and intensity of startle reaction in Topiramate group was significantly less than placebo group (p < 0.05).


The results of current study suggest that Topiramate is a safe well tolerate and significantly effective treatment for PTSD.


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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Omranifard, V., Akochekian, S. & Amanat, S. The comparison of topiramate and placebo in the treatment of posttraumatic stress disorder; randomized double blind study. Ann Gen Psychiatry 5 (Suppl 1), S225 (2006).

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