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Neuropathologically confirmed case of early onset alzheimer's disease with atypical clinical manifestation

Case Report

At Psychiatric Department of UH "Alexandrovska" died a 56 year old man with clinical diagnosis: not specified psychosis. The debut of symptoms was at the age of 53 with progressive memory decline and behavior disturbances. At the time of hospitalization, clinical picture was dominated by emotional and behavior changes, sleep disturbances, and loss of appetite. Computer tomography of brain revealed cortical atrophy. Frontal and hippocampal atrophy was confirmed by macroscopic examination of the brain. Histopathologically were found moderate neuritic plaques fulfilling CERAD criteria for definite Alzheimer's disease; neurofibrillary tangles and neuropil threads according to Braak and Braak pathological stage IV. Multidisciplinary approach including clinical, neuropsychological, neuroimaging and eventually neuropathological methods is necessary for differential diagnosis of early onset alzheimer's disease and other neurodegenerative disorders with dementia.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mehrabian, S., Kalev, O. & Traykov, L. Neuropathologically confirmed case of early onset alzheimer's disease with atypical clinical manifestation. Ann Gen Psychiatry 5 (Suppl 1), S277 (2006). https://doi.org/10.1186/1744-859X-5-S1-S277

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  • DOI: https://doi.org/10.1186/1744-859X-5-S1-S277

Keywords

  • Dementia
  • Sleep Disturbance
  • Pathological Stage
  • Multidisciplinary Approach
  • Neurofibrillary Tangle