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The efficacy of vitamin B6 for treatment of premenstrual dysphoric


Premenstrual syndrome (premenstrual tension or late luteal phase dysphoric disorder) is a complex psychological and somatic symptoms that appear in the luteal phase of the menstrual cycle and remit by beginning of menses. It seems that at least 5% of childbearing women are suffering from this disorder. To assess the efficacy of vitamin B6 for treatment of premenstrual dysphoric disorder a double-blind placebo controlled study was done.

Materials and methods

121 women, aged 20–45 years, who had premenstrual dyphoric disorder, according to 4th. Edition of Diagnostic and Statistical Manual of Mental Disorders, entered in a randomized double-blind trial in Isfahan Sadr clinic. The subjects followed by the modified Moos Menstrual Distress Questionnaire (MMDQ) for 3 months. Data analyzed by SPSS software using paired and student-tests.


In the 94 cases who completed the study, a significant superior effect of vitamin B6 was observed than placebo on emotional (but not somatic) symptoms of premenstrual dysphoric disorder.


It seems that vitamin B6 is an effective drug for relief of at least some of the symptoms of the premenstrual syndrom.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Maroufi, M., Marofi, M. The efficacy of vitamin B6 for treatment of premenstrual dysphoric. Ann Gen Psychiatry 5 (Suppl 1), S306 (2006).

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