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Familial Mediterranean Fever and Armenian Genocide: qualitative study and literature review


The first authors describing the Familial Meditteranan Fever Reiman, Squier, Mamou, described it after the Armenian Genocide among the Armenians who were inhabited in Lebanon (Anchar a village consisting of people exceptionally from Musaler) and in the United States. Other authors Nasaretian 1995 considered the disease to be an "adaptation disease". This multi-symptom, enigmatic and till the present undiscovered disease needs to be investigated from the viewpoint of posttraumatic stress disorder, as far as it can still last many years.

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125patients suffering from underwent clinical-psychopathological investigation, meantime were investigated the materials referring Familial Mediterranean Fever from the viewpoint of posttraumatic stress disorder (PTSD).


The results of the investigation show that the parents, the grandparents of the 85% of the patients are immigrants: The attack is a flashback – which is realized in such a stress situation, directed to the patient, personality, family the place of residence, reproducing what the organism had in the genetic memory connected with the trauma in the past, to which in the present it responses with its defensive mechanisms- fever, aseptic inflammation etc. Alexithymia is explained as a condition masked from, chronic morbid grief and depression. We connect the mechanisms causing alexithymia with extremely powerful stress impulse – the Armenian genocide, with its consequences as post traumatic stress disorder.


Familial Mediterranean Fever can be caused by powerful stress (genocide), genetically transferring untreated posttraumatic stress disorders (inter- attack period), flashbacks (pre-attack period), fever, aseptic inflammation (attack period), which presents defending factors for regulating the homoeostasis and at the present acts not adequately and is the main symptom of this disease. The discovery of alexithymia with patient suffering from Familial Mediterranean Fever, with accompanied, anxity and depression, also proves that the nature of FMF belong to the class of psychosomatic disorderse.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Nersisyan, A. Familial Mediterranean Fever and Armenian Genocide: qualitative study and literature review. Ann Gen Psychiatry 5 (Suppl 1), S312 (2006).

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