Frontotemporal Dementias: A Review

Table 1 Common clinical presentations of the various types of frontotemporal dementia.

	Common Initial	Behavioral Symptoms	Cognitive Symptoms	Commonly Affected
	Presentation			Brain Region
FvFTD^a	Personality	Occur Early:	Executive dysfunction	Frontal/prefrontal
	change	Disinhibition	Impaired working memory	cortex
		Impulsivity	Perseveration	Anterior temporal
		Stereotypies	Attentional deficits	cortex
		Apathy
		Hyperorality
SD^b	Language	Occur Early or Late:	Fluent dysphasia	Middle and inferior
	abnormality	Emotional distance	Impaired semantic memory	temporal neocortex
		Interpersonal coldness	Preserved autobiographical
			and working memory
PA^c	Language	Occur Late:	Non-fluent/expressive	Left perisylvian
	abnormality	May include any of the	dysphasia	cortex
		above

^a = Frontal variant frontotemporal dementia; ^b = Semantic dementia; ^c = Progressive aphasia

ISSN: 1744-859X